8Y6K
Cryo-EM structure of full-length MICAL1 in the autoinhibited state
Functional Information from PROSITE/UniProt
| site_id | PS00478 |
| Number of Residues | 35 |
| Details | LIM_DOMAIN_1 LIM zinc-binding domain signature. CalCgehlyvlerlcvnghf.....FHrsCfrChtCeatL |
| Chain | Residue | Details |
| A | CYS697-LEU731 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8VDP3 |
| Chain | Residue | Details |
| A | CYS95 | |
| A | GLU114 | |
| A | ARG121 | |
| A | PHE181 | |
| A | TYR293 | |
| A | ASP393 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0007744|PDB:2CO8 |
| Chain | Residue | Details |
| A | CYS697 | |
| A | CYS700 | |
| A | HIS718 | |
| A | CYS721 | |
| A | CYS724 | |
| A | CYS727 | |
| A | CYS747 | |
| A | HIS750 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Important for interaction with ARHGAP26 AND ARHGAP10 => ECO:0000269|PubMed:32344433 |
| Chain | Residue | Details |
| A | LYS832 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:D3ZBP4 |
| Chain | Residue | Details |
| A | THR475 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER617 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| A | SER872 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| A | SER875 | |
| A | SER876 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1057 |
