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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8Y5R

E.coli Transcription translation coupling complex in TTC-B state 5 (subclass 1) containing mRNA with 27-mer spacer, NusG, NusA, fMet-tRNA(iMet), Phe-tRNA(Phe), and fusidic acid

This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
site_idPS00049
Number of Residues27
DetailsRIBOSOMAL_L14 Ribosomal protein L14 signature. AVVVrtkkgvrrp.DGsvirFdgNacVL
ChainResidueDetails
kALA60-LEU86
site_idPS00050
Number of Residues16
DetailsRIBOSOMAL_L23 Ribosomal protein L23 signature. KKAYVTLKegqnldfV
ChainResidueDetails
tLYS81-VAL96
site_idPS00052
Number of Residues27
DetailsRIBOSOMAL_S7 Ribosomal protein S7 signature. SeLlakFVnilmvdGKKstaesIVysA
ChainResidueDetails
LSER19-ALA45
site_idPS00053
Number of Residues18
DetailsRIBOSOMAL_S8 Ribosomal protein S8 signature. GiaVVSTSkGVMtdraAR
ChainResidueDetails
MGLY99-ARG116
site_idPS00054
Number of Residues23
DetailsRIBOSOMAL_S11 Ribosomal protein S11 signature. IrALnaA.GFrItnitDvTPiPHN
ChainResidueDetails
PILE96-ASN118
site_idPS00055
Number of Residues8
DetailsRIBOSOMAL_S12 Ribosomal protein S12 signature. KkPNSAlR
ChainResidueDetails
QLYS42-ARG49
site_idPS00056
Number of Residues13
DetailsRIBOSOMAL_S17 Ribosomal protein S17 signature. GDvVeIrEcRPLS
ChainResidueDetails
VGLY55-SER67
site_idPS00057
Number of Residues24
DetailsRIBOSOMAL_S18 Ribosomal protein S18 signature. IDYkd.IatLknYITEs.GKIvpsRI
ChainResidueDetails
WILE20-ILE43
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. PdhkhavialTsiYGVGKTRSkAILaAAG
ChainResidueDetails
RPRO9-GLY37
site_idPS00301
Number of Residues16
DetailsG_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DWmeqEQeRGITItsA
ChainResidueDetails
0ASP51-ALA66
site_idPS00323
Number of Residues25
DetailsRIBOSOMAL_S19 Ribosomal protein S19 signature. NGRqhvpvfVtdemVGhkLGEFapT
ChainResidueDetails
XASN52-THR76
site_idPS00358
Number of Residues17
DetailsRIBOSOMAL_L5 Ribosomal protein L5 signature. LaaISGQkpLiTkARkS
ChainResidueDetails
eLEU56-SER72
site_idPS00359
Number of Residues16
DetailsRIBOSOMAL_L11 Ribosomal protein L11 signature. RsIeGTarSMGlVVeD
ChainResidueDetails
iARG126-ASP141
site_idPS00360
Number of Residues19
DetailsRIBOSOMAL_S9 Ribosomal protein S9 signature. GGGisGQagAirhGiTRAL
ChainResidueDetails
NGLY68-LEU86
site_idPS00361
Number of Residues16
DetailsRIBOSOMAL_S10 Ribosomal protein S10 signature. AkrtGAqvrGPIpLPT
ChainResidueDetails
OALA29-THR44
site_idPS00362
Number of Residues31
DetailsRIBOSOMAL_S15 Ribosomal protein S15 signature. LqgHFaehKkDhhSrrgLlrMvsqrrkLldY
ChainResidueDetails
TLEU38-TYR68
site_idPS00430
Number of Residues66
DetailsTONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. mireerllkvlraphvsekastameksntivlkvakdatkaeikaavqklfevevevv.........................................................NTLVVKGK
ChainResidueDetails
tMET1-LYS66
site_idPS00464
Number of Residues25
DetailsRIBOSOMAL_L22 Ribosomal protein L22 signature. KriMpRAkGRadrilkrtSHITVvV
ChainResidueDetails
sLYS83-VAL107
site_idPS00467
Number of Residues12
DetailsRIBOSOMAL_L2 Ribosomal protein L2 signature. PtvRGTAmNPvD
ChainResidueDetails
bPRO217-ASP228
site_idPS00474
Number of Residues24
DetailsRIBOSOMAL_L3 Ribosomal protein L3 signature. FadvkkvDvtGtSkGKGfaGtvkR
ChainResidueDetails
cPHE101-ARG124
site_idPS00475
Number of Residues31
DetailsRIBOSOMAL_L15 Ribosomal protein L15 signature. KVILaGeVttp..VtVrglrVTkgAraaIeaaG
ChainResidueDetails
lLYS109-GLY139
site_idPS00525
Number of Residues9
DetailsRIBOSOMAL_L6_1 Ribosomal protein L6 signature 1. PEpYKGKGV
ChainResidueDetails
fPRO153-VAL161
site_idPS00527
Number of Residues23
DetailsRIBOSOMAL_S14 Ribosomal protein S14 signature. R.CrqtgrphgflrkFGLSRiKVR
ChainResidueDetails
SARG62-ARG84
site_idPS00548
Number of Residues35
DetailsRIBOSOMAL_S3 Ribosomal protein S3 signature. ARtewyreGrVplHt..LradIDyntseahTtyGviG
ChainResidueDetails
HALA162-GLY196
site_idPS00579
Number of Residues15
DetailsRIBOSOMAL_L29 Ribosomal protein L29 signature. QSHLLKqVRRDVARV
ChainResidueDetails
yGLN39-VAL53
site_idPS00582
Number of Residues20
DetailsRIBOSOMAL_L33 Ribosomal protein L33 signature. YtTtKNkrtkPekLElkKFD
ChainResidueDetails
CTYR20-ASP39
site_idPS00585
Number of Residues33
DetailsRIBOSOMAL_S5 Ribosomal protein S5 signature. GRifsFtAltVVGDgn.GrVGfGygkar.EVpa.AI
ChainResidueDetails
JGLY27-ILE59
site_idPS00586
Number of Residues12
DetailsRIBOSOMAL_L16_1 Ribosomal protein L16 signature 1. KRqGKIWIRVFP
ChainResidueDetails
mLYS58-PRO69
site_idPS00632
Number of Residues25
DetailsRIBOSOMAL_S4 Ribosomal protein S4 signature. LEgRLdnvVYRmgfGaTraeARqLV
ChainResidueDetails
ILEU93-VAL117
site_idPS00634
Number of Residues33
DetailsRIBOSOMAL_L30 Ribosomal protein L30 signature. TLlgLgLrRigHtVeredtpairgMInaVsfMV
ChainResidueDetails
zTHR22-VAL54
site_idPS00646
Number of Residues14
DetailsRIBOSOMAL_S13_1 Ribosomal protein S13 signature. RGlRHrrGlpVRGQ
ChainResidueDetails
RARG86-GLN99
site_idPS00651
Number of Residues28
DetailsRIBOSOMAL_L9 Ribosomal protein L9 signature. GslGdqvnVkaGYarNFLvpqgkAvpaT
ChainResidueDetails
gGLY13-THR40
site_idPS00701
Number of Residues12
DetailsRIBOSOMAL_L16_2 Ribosomal protein L16 signature 2. RMGkGKGnveyW
ChainResidueDetails
mARG81-TRP92
site_idPS00732
Number of Residues10
DetailsRIBOSOMAL_S16 Ribosomal protein S16 signature. VtIRLARHGA
ChainResidueDetails
UVAL2-ALA11
site_idPS00783
Number of Residues23
DetailsRIBOSOMAL_L13 Ribosomal protein L13 signature. VKGMLPkgpl.GRamfrkLkVYaG
ChainResidueDetails
jVAL105-GLY127
site_idPS00784
Number of Residues20
DetailsRIBOSOMAL_L34 Ribosomal protein L34 signature. KRTFQpsvlkRnrsh.GFraR
ChainResidueDetails
DLYS2-ARG21
site_idPS00828
Number of Residues27
DetailsRIBOSOMAL_L36 Ribosomal protein L36 signature. CrnCkiVkRdgvIrViCsaepKHkQrQ
ChainResidueDetails
FCYS11-GLN37
site_idPS00831
Number of Residues15
DetailsRIBOSOMAL_L27 Ribosomal protein L27 signature. GsIIvRQRGtkfhaG
ChainResidueDetails
wGLY30-GLY44
site_idPS00936
Number of Residues27
DetailsRIBOSOMAL_L35 Ribosomal protein L35 signature. KTVrGAaKRFkktgkggfkhkhanl.RH
ChainResidueDetails
ELYS4-HIS30
site_idPS00937
Number of Residues17
DetailsRIBOSOMAL_L20 Ribosomal protein L20 signature. KrqfRqLWIARINaaaR
ChainResidueDetails
qLYS53-ARG69
site_idPS00962
Number of Residues12
DetailsRIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. MrDMLKAGVHFG
ChainResidueDetails
GMET5-GLY16
site_idPS00963
Number of Residues25
DetailsRIBOSOMAL_S2_2 Ribosomal protein S2 signature 2. PdaLFViDadhEhiaIkEannlGIP
ChainResidueDetails
GPRO157-PRO181
site_idPS01014
Number of Residues10
DetailsNUSG Transcription termination factor nusG signature. IFGRaTPVeL
ChainResidueDetails
NGILE164-LEU173
site_idPS01015
Number of Residues16
DetailsRIBOSOMAL_L19 Ribosomal protein L19 signature. VkRrGAVR.KAKLYYLR
ChainResidueDetails
pVAL85-ARG100
site_idPS01048
Number of Residues10
DetailsRIBOSOMAL_S6 Ribosomal protein S6 signature. GrRQLAYpIN
ChainResidueDetails
KGLY43-ASN52
site_idPS01108
Number of Residues18
DetailsRIBOSOMAL_L24 Ribosomal protein L24 signature. DDeViVLtGkdKGkr.GkV
ChainResidueDetails
uASP7-VAL24
site_idPS01143
Number of Residues22
DetailsRIBOSOMAL_L31 Ribosomal protein L31 signature. DVcskcHPFFTgkqrdvatg....GR
ChainResidueDetails
AASP35-ARG56
site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKMAGrHGNKGV
ChainResidueDetails
B2GLY1063-VAL1075
site_idPS01167
Number of Residues23
DetailsRIBOSOMAL_L17 Ribosomal protein L17 signature. IkTTlpKaKelrrvvEpLITlAK
ChainResidueDetails
nILE34-LYS56
site_idPS01169
Number of Residues23
DetailsRIBOSOMAL_L21 Ribosomal protein L21 signature. VkivKfrrRKhyrkqqGHRQwfT
ChainResidueDetails
rVAL72-THR94
site_idPS01181
Number of Residues13
DetailsRIBOSOMAL_S21 Ribosomal protein S21 signature. DvALRRFKRsceK
ChainResidueDetails
ZASP12-LYS24
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues9
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues25
DetailsCompositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"21151122","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues68
DetailsDomain: {"description":"KH type-2"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues60
DetailsDomain: {"description":"S4 RNA-binding"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues63
DetailsDomain: {"description":"S5 DRBM"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"3-methylthioaspartic acid","evidences":[{"source":"PubMed","id":"8844851","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues52
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues9
DetailsCompositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"365579","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"331083","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01365","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"N,N,N-trimethylalanine","evidences":[{"source":"PubMed","id":"7004866","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"source":"PubMed","id":"7004866","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues10
DetailsCompositional bias: {"description":"Gly residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsModified residue: {"description":"N-methylmethionine","evidences":[{"source":"PubMed","id":"786730","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"(3R)-3-hydroxyarginine","evidences":[{"source":"PubMed","id":"23103944","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34403461","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34504068","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7O19","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7O1A","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7O1C","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7OIZ","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7OJ0","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues80
DetailsRegion: {"description":"Alpha C-terminal domain (alpha-CTD); not required for RNAP assembly or function"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsModified residue: {"description":"ADP-ribosylarginine","evidences":[{"source":"PubMed","id":"4371081","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"21696463","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine; by PatZ","evidences":[{"source":"PubMed","id":"21696463","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues11
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32871103","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MEY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues65
DetailsDomain: {"description":"S1 motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00945","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues63
DetailsDomain: {"description":"KH 1","evidences":[{"source":"HAMAP-Rule","id":"MF_00945","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues66
DetailsDomain: {"description":"KH 2","evidences":[{"source":"HAMAP-Rule","id":"MF_00945","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues50
DetailsRepeat: {"description":"1"}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues50
DetailsRepeat: {"description":"2"}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues136
DetailsRegion: {"description":"N-terminal domain (NTD) interacts with RNAP","evidences":[{"source":"PubMed","id":"21922055","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues81
DetailsRegion: {"description":"Acidic repeat 1 (AR1)","evidences":[{"source":"PubMed","id":"21922055","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues125
DetailsRegion: {"description":"2 X 51 AA approximate repeats"}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues31
DetailsDomain: {"description":"KOW","evidences":[{"source":"HAMAP-Rule","id":"MF_00948","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues14
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2025-08-27

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