8Y3C
Cryo-EM structure of the overlapping di-nucleosome (closed form)
Functional Information from PROSITE/UniProt
| site_id | PS00046 |
| Number of Residues | 7 |
| Details | HISTONE_H2A Histone H2A signature. AGLqFPV |
| Chain | Residue | Details |
| C | ALA21-VAL27 |
| site_id | PS00047 |
| Number of Residues | 5 |
| Details | HISTONE_H4 Histone H4 signature. GAKRH |
| Chain | Residue | Details |
| B | GLY14-HIS18 |
| site_id | PS00322 |
| Number of Residues | 7 |
| Details | HISTONE_H3_1 Histone H3 signature 1. KAPRKQL |
| Chain | Residue | Details |
| A | LYS14-LEU20 |
| site_id | PS00357 |
| Number of Residues | 23 |
| Details | HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG |
| Chain | Residue | Details |
| D | ARG92-GLY114 |
| site_id | PS00959 |
| Number of Residues | 9 |
| Details | HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI |
| Chain | Residue | Details |
| A | PRO66-ILE74 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | MOD_RES: N-acetylproline => ECO:0000250|UniProtKB:P23527 |
| Chain | Residue | Details |
| D | PRO1 | |
| H | PRO1 | |
| N | PRO1 | |
| P | LYS16-LYS20 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | MOD_RES: ADP-ribosyl glutamic acid => ECO:0000269|PubMed:27530147 |
| Chain | Residue | Details |
| D | GLU2 | |
| H | GLU2 | |
| N | GLU2 | |
| P | SER1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | MOD_RES: N6-lactoyllysine; alternate => ECO:0000269|PubMed:31645732 |
| Chain | Residue | Details |
| D | LYS5 | |
| H | LYS11 | |
| H | LYS15 | |
| H | LYS16 | |
| H | LYS20 | |
| H | LYS23 | |
| H | LYS43 | |
| H | LYS85 | |
| N | LYS5 | |
| N | LYS11 | |
| N | LYS15 | |
| D | LYS11 | |
| N | LYS16 | |
| N | LYS20 | |
| N | LYS23 | |
| N | LYS43 | |
| N | LYS85 | |
| D | LYS15 | |
| D | LYS16 | |
| D | LYS20 | |
| D | LYS23 | |
| D | LYS43 | |
| D | LYS85 | |
| H | LYS5 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | MOD_RES: ADP-ribosylserine => ECO:0000269|PubMed:34874266 |
| Chain | Residue | Details |
| D | SER6 | |
| H | SER6 | |
| N | SER6 | |
| G | LYS95 | |
| M | LYS9 | |
| M | LYS95 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-crotonyllysine; alternate => ECO:0000269|PubMed:21925322 |
| Chain | Residue | Details |
| D | LYS12 | |
| P | LYS8 | |
| P | LYS16 | |
| P | LYS44 | |
| H | LYS12 | |
| N | LYS12 | |
| F | LYS8 | |
| F | LYS16 | |
| F | LYS44 | |
| L | LYS8 | |
| L | LYS16 | |
| L | LYS44 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:12757711 |
| Chain | Residue | Details |
| D | SER14 | |
| L | LYS31 | |
| L | LYS77 | |
| L | LYS91 | |
| P | LYS12 | |
| P | LYS31 | |
| P | LYS77 | |
| P | LYS91 | |
| H | SER14 | |
| N | SER14 | |
| B | LYS91 | |
| F | LYS12 | |
| F | LYS31 | |
| F | LYS77 | |
| F | LYS91 | |
| L | LYS12 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:24681537 |
| Chain | Residue | Details |
| D | LYS24 | |
| H | LYS24 | |
| N | LYS24 | |
| G | LYS75 | |
| M | LYS74 | |
| M | LYS75 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 9 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| D | LYS34 | |
| D | LYS116 | |
| D | LYS120 | |
| H | LYS34 | |
| H | LYS116 | |
| H | LYS120 | |
| N | LYS34 | |
| N | LYS116 | |
| N | LYS120 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | MOD_RES: PolyADP-ribosyl glutamic acid => ECO:0000250|UniProtKB:Q64475 |
| Chain | Residue | Details |
| D | GLU35 | |
| H | GLU35 | |
| N | GLU35 | |
| G | LYS118 | |
| G | LYS119 | |
| G | LYS125 | |
| M | LYS118 | |
| M | LYS119 | |
| M | LYS125 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine; by AMPK => ECO:0000250|UniProtKB:Q64475 |
| Chain | Residue | Details |
| D | SER36 | |
| H | SER36 | |
| N | SER36 | |
| P | LYS59 | |
| K | LYS14 | |
| K | LYS56 | |
| O | LYS14 | |
| O | LYS56 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16627869 |
| Chain | Residue | Details |
| D | LYS46 | |
| D | LYS108 | |
| H | LYS46 | |
| H | LYS108 | |
| N | LYS46 | |
| N | LYS108 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-(2-hydroxyisobutyryl)lysine; alternate => ECO:0000269|PubMed:24681537 |
| Chain | Residue | Details |
| D | LYS57 | |
| H | LYS57 | |
| N | LYS57 | |
| G | LYS119 | |
| K | LYS18 | |
| M | LYS119 | |
| O | LYS18 | |
| O | LYS64 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 3 |
| Details | MOD_RES: Dimethylated arginine => ECO:0000250|UniProtKB:Q96A08 |
| Chain | Residue | Details |
| D | ARG79 | |
| H | ARG79 | |
| N | ARG79 | |
| P | TYR88 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 6 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q96A08 |
| Chain | Residue | Details |
| D | ARG86 | |
| D | ARG92 | |
| H | ARG86 | |
| H | ARG92 | |
| N | ARG86 | |
| N | ARG92 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q00729 |
| Chain | Residue | Details |
| D | THR115 | |
| H | THR115 | |
| N | THR115 | |
| F | LYS91 | |
| L | LYS91 | |
| P | LYS91 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250|UniProtKB:P62807 |
| Chain | Residue | Details |
| D | SER112 | |
| P | LYS20 | |
| P | LYS59 | |
| P | LYS79 | |
| H | SER112 | |
| N | SER112 | |
| F | LYS20 | |
| F | LYS59 | |
| F | LYS79 | |
| L | LYS20 | |
| L | LYS59 | |
| L | LYS79 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P58876 |
| Chain | Residue | Details |
| D | LYS5 | |
| H | LYS5 | |
| N | LYS5 | |
| P | LYS31 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:16713563 |
| Chain | Residue | Details |
| A | LYS37 | |
| D | LYS120 | |
| K | LYS37 | |
| H | LYS120 | |
| N | LYS120 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:Q5QNW6 |
| Chain | Residue | Details |
| D | LYS20 | |
| H | LYS20 | |
| N | LYS20 | |
| O | TYR41 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:21726816 |
| Chain | Residue | Details |
| D | LYS34 | |
| H | LYS34 | |
| N | LYS34 | |
| O | SER57 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:29211711 |
| Chain | Residue | Details |
| A | LYS79 | |
| E | LYS79 | |
| K | LYS79 | |
| O | LYS79 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:20850016 |
| Chain | Residue | Details |
| A | THR80 | |
| E | THR80 | |
| K | THR80 | |
| O | THR80 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| A | SER86 | |
| E | SER86 | |
| K | SER86 | |
| O | SER86 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3 |
| Chain | Residue | Details |
| A | THR107 | |
| E | THR107 | |
| K | THR107 | |
| O | THR107 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297 |
| Chain | Residue | Details |
| A | LYS115 | |
| E | LYS115 | |
| K | LYS115 | |
| O | LYS115 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:27436229 |
| Chain | Residue | Details |
| A | LYS122 | |
| E | LYS122 | |
| K | LYS122 | |
| O | LYS122 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 4 |
| Details | LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806 |
| Chain | Residue | Details |
| A | LYS18 | |
| E | LYS18 | |
| K | LYS18 | |
| O | LYS18 |
