8Y2N
Cryo-EM structure of the apo Lac1-Lip1 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006665 | biological_process | sphingolipid metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0034399 | cellular_component | nuclear periphery |
| A | 0046513 | biological_process | ceramide biosynthetic process |
| A | 0050291 | molecular_function | sphingosine N-acyltransferase activity |
| A | 0061576 | cellular_component | acyl-CoA ceramide synthase complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005635 | cellular_component | nuclear envelope |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0046513 | biological_process | ceramide biosynthetic process |
| B | 0050291 | molecular_function | sphingosine N-acyltransferase activity |
| B | 0061576 | cellular_component | acyl-CoA ceramide synthase complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005789 | cellular_component | endoplasmic reticulum membrane |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0006665 | biological_process | sphingolipid metabolic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016740 | molecular_function | transferase activity |
| C | 0034399 | cellular_component | nuclear periphery |
| C | 0046513 | biological_process | ceramide biosynthetic process |
| C | 0050291 | molecular_function | sphingosine N-acyltransferase activity |
| C | 0061576 | cellular_component | acyl-CoA ceramide synthase complex |
| D | 0005515 | molecular_function | protein binding |
| D | 0005635 | cellular_component | nuclear envelope |
| D | 0005783 | cellular_component | endoplasmic reticulum |
| D | 0005789 | cellular_component | endoplasmic reticulum membrane |
| D | 0006629 | biological_process | lipid metabolic process |
| D | 0046513 | biological_process | ceramide biosynthetic process |
| D | 0050291 | molecular_function | sphingosine N-acyltransferase activity |
| D | 0061576 | cellular_component | acyl-CoA ceramide synthase complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 364 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"37953642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 142 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"37953642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 66 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37953642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 434 |
| Details | Domain: {"description":"TLC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00205","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QTR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8Y2M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 50 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37953642","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8IZD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QTN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QTR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QTN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QTN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QTN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 38 |
| Details | Transmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 218 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"15692566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
