Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8Y2D

Cryo-EM structure of human dopamine transporter in complex with dopamine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00610
Number of Residues	15
Details	NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcykNGGGaF

Chain	Residue	Details
A	TRP84-PHE98

site_id	PS00754
Number of Residues	21
Details	NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YLfsSFTteLPWihCnnswNS

Chain	Residue	Details
A	TYR166-SER186

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	31
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112703","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	43
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112703","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112703","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	51
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112703","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	28
Details	Transmembrane: {"description":"Discontinuously helical; Name=6","evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112703","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112703","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	41
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112703","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112703","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	32
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112703","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	52
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112703","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112703","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112703","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	29
Details	Region: {"description":"Interaction with TGFB1I1","evidences":[{"source":"PubMed","id":"12177201","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39112703","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8Y2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8Y2D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39112703","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8Y2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Site: {"description":"Contributes to high-affinity binding to cocaine","evidences":[{"source":"UniProtKB","id":"Q61327","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"39112701","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8Y2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)