8Y2D
Cryo-EM structure of human dopamine transporter in complex with dopamine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00610 |
| Number of Residues | 15 |
| Details | NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcykNGGGaF |
| Chain | Residue | Details |
| A | TRP84-PHE98 |
| site_id | PS00754 |
| Number of Residues | 21 |
| Details | NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YLfsSFTteLPWihCnnswNS |
| Chain | Residue | Details |
| A | TYR166-SER186 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 31 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0007744|PDB:8VBY, ECO:0007744|PDB:8Y2C, ECO:0007744|PDB:8Y2D, ECO:0007744|PDB:8Y2E, ECO:0007744|PDB:8Y2F, ECO:0007744|PDB:8Y2G, ECO:0007744|PDB:9EO4 |
| Chain | Residue | Details |
| A | GLY96-GLY127 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 43 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0007744|PDB:8VBY, ECO:0007744|PDB:8Y2C, ECO:0007744|PDB:8Y2D, ECO:0007744|PDB:8Y2E, ECO:0007744|PDB:8Y2F, ECO:0007744|PDB:8Y2G, ECO:0007744|PDB:9EO4 |
| Chain | Residue | Details |
| A | ALA128-PHE171 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 115 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0007744|PDB:8VBY, ECO:0007744|PDB:8Y2C, ECO:0007744|PDB:8Y2D, ECO:0007744|PDB:8Y2E, ECO:0007744|PDB:8Y2F, ECO:0007744|PDB:8Y2G, ECO:0007744|PDB:9EO4 |
| Chain | Residue | Details |
| A | THR172-PRO236 | |
| A | PRO288-CYS306 | |
| A | VAL377-THR400 | |
| A | PHE543-PHE553 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0007744|PDB:8VBY, ECO:0007744|PDB:8Y2C, ECO:0007744|PDB:8Y2D, ECO:0007744|PDB:8Y2E, ECO:0007744|PDB:8Y2F, ECO:0007744|PDB:8Y2G, ECO:0007744|PDB:9EO4 |
| Chain | Residue | Details |
| A | ARG237-TRP256 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 30 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0007744|PDB:8VBY, ECO:0007744|PDB:8Y2C, ECO:0007744|PDB:8Y2D, ECO:0007744|PDB:8Y2E, ECO:0007744|PDB:8Y2F, ECO:0007744|PDB:8Y2G, ECO:0007744|PDB:9EO4 |
| Chain | Residue | Details |
| A | LYS257-LEU287 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 28 |
| Details | TRANSMEM: Discontinuously helical; Name=6 => ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0007744|PDB:8VBY, ECO:0007744|PDB:8Y2C, ECO:0007744|PDB:8Y2D, ECO:0007744|PDB:8Y2E, ECO:0007744|PDB:8Y2F, ECO:0007744|PDB:8Y2G, ECO:0007744|PDB:9EO4 |
| Chain | Residue | Details |
| A | GLU307-TYR335 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0007744|PDB:8VBY, ECO:0007744|PDB:8Y2C, ECO:0007744|PDB:8Y2D, ECO:0007744|PDB:8Y2E, ECO:0007744|PDB:8Y2F, ECO:0007744|PDB:8Y2G, ECO:0007744|PDB:9EO4 |
| Chain | Residue | Details |
| A | ASN336-SER376 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 41 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0007744|PDB:8VBY, ECO:0007744|PDB:8Y2C, ECO:0007744|PDB:8Y2D, ECO:0007744|PDB:8Y2E, ECO:0007744|PDB:8Y2F, ECO:0007744|PDB:8Y2G, ECO:0007744|PDB:9EO4 |
| Chain | Residue | Details |
| A | LEU401-HIS442 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0007744|PDB:8VBY, ECO:0007744|PDB:8Y2C, ECO:0007744|PDB:8Y2D, ECO:0007744|PDB:8Y2E, ECO:0007744|PDB:8Y2F, ECO:0007744|PDB:8Y2G, ECO:0007744|PDB:9EO4 |
| Chain | Residue | Details |
| A | ARG443-ASN466 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 32 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0007744|PDB:8VBY, ECO:0007744|PDB:8Y2C, ECO:0007744|PDB:8Y2D, ECO:0007744|PDB:8Y2E, ECO:0007744|PDB:8Y2F, ECO:0007744|PDB:8Y2G, ECO:0007744|PDB:9EO4 |
| Chain | Residue | Details |
| A | GLY467-TYR499 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 52 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0007744|PDB:8VBY, ECO:0007744|PDB:8Y2C, ECO:0007744|PDB:8Y2D, ECO:0007744|PDB:8Y2E, ECO:0007744|PDB:8Y2F, ECO:0007744|PDB:8Y2G, ECO:0007744|PDB:9EO4 |
| Chain | Residue | Details |
| A | GLY500-PRO516 | |
| A | PRO584-VAL620 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0007744|PDB:8VBY, ECO:0007744|PDB:8Y2C, ECO:0007744|PDB:8Y2D, ECO:0007744|PDB:8Y2E, ECO:0007744|PDB:8Y2F, ECO:0007744|PDB:8Y2G, ECO:0007744|PDB:9EO4 |
| Chain | Residue | Details |
| A | SER517-THR542 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0007744|PDB:8VBY, ECO:0007744|PDB:8Y2C, ECO:0007744|PDB:8Y2D, ECO:0007744|PDB:8Y2E, ECO:0007744|PDB:8Y2F, ECO:0007744|PDB:8Y2G, ECO:0007744|PDB:9EO4 |
| Chain | Residue | Details |
| A | PRO554-LEU583 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0007744|PDB:8VBY, ECO:0007744|PDB:9EO4 |
| Chain | Residue | Details |
| A | GLY75 | |
| A | VAL78 | |
| A | LEU418 | |
| A | ASP421 | |
| A | SER422 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:39112701, ECO:0007744|PDB:8Y2D, ECO:0007744|PDB:8Y2G |
| Chain | Residue | Details |
| A | ALA77 | |
| A | ASP79 | |
| A | ASN82 | |
| A | SER321 | |
| A | ASN353 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:39112701, ECO:0007744|PDB:8Y2D |
| Chain | Residue | Details |
| A | SER149 | |
| A | GLY153 | |
| A | PHE320 | |
| A | ALA423 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0007744|PDB:8Y2D, ECO:0007744|PDB:8Y2G, ECO:0007744|PDB:9EO4 |
| Chain | Residue | Details |
| A | GLN317 | |
| A | SER357 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | SITE: Contributes to high-affinity binding to cocaine => ECO:0000250|UniProtKB:Q61327 |
| Chain | Residue | Details |
| A | PHE105 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:39112701, ECO:0007744|PDB:8Y2C, ECO:0007744|PDB:8Y2E, ECO:0007744|PDB:8Y2F, ECO:0007744|PDB:8Y2G |
| Chain | Residue | Details |
| A | ASN181 | |
| A | ASN188 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN205 |
