8Y2C
Cryo-EM structure of human dopamine transporter in apo state
Functional Information from PROSITE/UniProt
site_id | PS00610 |
Number of Residues | 15 |
Details | NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcykNGGGaF |
Chain | Residue | Details |
A | TRP84-PHE98 |
site_id | PS00754 |
Number of Residues | 21 |
Details | NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YLfsSFTteLPWihCnnswNS |
Chain | Residue | Details |
A | TYR166-SER186 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
Chain | Residue | Details |
A | PHE69-LEU89 |
site_id | SWS_FT_FI2 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
Chain | Residue | Details |
A | GLY96-MET116 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
Chain | Residue | Details |
A | GLY140-ILE160 |
site_id | SWS_FT_FI4 |
Number of Residues | 76 |
Details | TOPO_DOM: Extracellular => ECO:0000255 |
Chain | Residue | Details |
A | ALA161-ARG237 |
site_id | SWS_FT_FI5 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
Chain | Residue | Details |
A | TRP238-TRP256 |
site_id | SWS_FT_FI6 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
Chain | Residue | Details |
A | VAL265-LEU282 |
site_id | SWS_FT_FI7 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
Chain | Residue | Details |
A | VAL318-TYR335 |
site_id | SWS_FT_FI8 |
Number of Residues | 21 |
Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
Chain | Residue | Details |
A | ILE347-LEU368 |
site_id | SWS_FT_FI9 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=8 => ECO:0000255 |
Chain | Residue | Details |
A | LEU401-ILE420 |
site_id | SWS_FT_FI10 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=9 => ECO:0000255 |
Chain | Residue | Details |
A | LEU447-THR465 |
site_id | SWS_FT_FI11 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=10 => ECO:0000255 |
Chain | Residue | Details |
A | GLY481-VAL501 |
site_id | SWS_FT_FI12 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=11 => ECO:0000255 |
Chain | Residue | Details |
A | LEU522-VAL541 |
site_id | SWS_FT_FI13 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=12 => ECO:0000255 |
Chain | Residue | Details |
A | LEU560-TYR578 |
site_id | SWS_FT_FI14 |
Number of Residues | 41 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | LYS579-VAL620 |
site_id | SWS_FT_FI15 |
Number of Residues | 9 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q7K4Y6 |
Chain | Residue | Details |
A | GLY75 | |
A | ALA77 | |
A | VAL78 | |
A | ASN82 | |
A | SER321 | |
A | ASN353 | |
A | LEU418 | |
A | ASP421 | |
A | SER422 |
site_id | SWS_FT_FI16 |
Number of Residues | 1 |
Details | SITE: Contributes to high-affinity binding to cocaine => ECO:0000250|UniProtKB:Q61327 |
Chain | Residue | Details |
A | PHE105 |
site_id | SWS_FT_FI17 |
Number of Residues | 3 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN181 | |
A | ASN188 | |
A | ASN205 |