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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8Y1E

3up-TM conformation of HKU1-B S protein after incubation of the receptor

Functional Information from GO Data
ChainGOidnamespacecontents
A0016020cellular_componentmembrane
A0019031cellular_componentviral envelope
A0019064biological_processfusion of virus membrane with host plasma membrane
A0039654biological_processfusion of virus membrane with host endosome membrane
A0046813biological_processreceptor-mediated virion attachment to host cell
A0055036cellular_componentvirion membrane
A0075509biological_processendocytosis involved in viral entry into host cell
B0016020cellular_componentmembrane
B0019031cellular_componentviral envelope
B0019064biological_processfusion of virus membrane with host plasma membrane
B0039654biological_processfusion of virus membrane with host endosome membrane
B0046813biological_processreceptor-mediated virion attachment to host cell
B0055036cellular_componentvirion membrane
B0075509biological_processendocytosis involved in viral entry into host cell
C0016020cellular_componentmembrane
C0019031cellular_componentviral envelope
C0019064biological_processfusion of virus membrane with host plasma membrane
C0039654biological_processfusion of virus membrane with host endosome membrane
C0046813biological_processreceptor-mediated virion attachment to host cell
C0055036cellular_componentvirion membrane
C0075509biological_processendocytosis involved in viral entry into host cell
D0004252molecular_functionserine-type endopeptidase activity
D0006508biological_processproteolysis
D0016020cellular_componentmembrane
E0004252molecular_functionserine-type endopeptidase activity
E0006508biological_processproteolysis
E0016020cellular_componentmembrane
F0004252molecular_functionserine-type endopeptidase activity
F0006508biological_processproteolysis
F0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC
ChainResidueDetails
DVAL292-CYS297
site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV
ChainResidueDetails
DASP435-VAL446
site_idPS01209
Number of Residues23
DetailsLDLRA_1 LDL-receptor class A (LDLRA) domain signature. CInpsnw.CDgvsHCpgg.EDEnr...C
ChainResidueDetails
DCYS126-CYS148
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues840
DetailsDomain: {"description":"BetaCoV S1-NTD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01270","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues840
DetailsDomain: {"description":"BetaCoV S1-CTD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues63
DetailsRegion: {"description":"Fusion peptide 1","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues60
DetailsRegion: {"description":"Fusion peptide 2","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues150
DetailsRegion: {"description":"Heptad repeat 1","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues132
DetailsCoiled coil: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsSite: {"description":"Cleavage; by host","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues3
DetailsSite: {"description":"Cleavage","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues75
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues279
DetailsDomain: {"description":"SRCR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XYD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HD8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues708
DetailsDomain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XYD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HD8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues390
DetailsRegion: {"description":"HKU1-CoV S protein-binding","evidences":[{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964328","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues3
DetailsActive site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11245484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues6
DetailsActive site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues3
DetailsSite: {"description":"Cleavage; by autolysis","evidences":[{"source":"PubMed","id":"11245484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964328","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XYD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8S0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8S0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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