8XZA

BA.2.86 Spike in complex with bovine ACE2 (Local refinement)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008241	molecular_function	peptidyl-dipeptidase activity
A	0016020	cellular_component	membrane
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0016020	cellular_component	membrane
B	0019031	cellular_component	viral envelope
B	0019062	biological_process	virion attachment to host cell
B	0019064	biological_process	fusion of virus membrane with host plasma membrane
B	0020002	cellular_component	host cell plasma membrane
B	0039587	biological_process	symbiont-mediated-mediated suppression of host tetherin activity
B	0039654	biological_process	fusion of virus membrane with host endosome membrane
B	0039660	molecular_function	structural constituent of virion
B	0039663	biological_process	membrane fusion involved in viral entry into host cell
B	0042802	molecular_function	identical protein binding
B	0043655	cellular_component	host extracellular space
B	0044173	cellular_component	host cell endoplasmic reticulum-Golgi intermediate compartment membrane
B	0044228	cellular_component	host cell surface
B	0044423	cellular_component	virion component
B	0046598	biological_process	positive regulation of viral entry into host cell
B	0046718	biological_process	symbiont entry into host cell
B	0046789	molecular_function	host cell surface receptor binding
B	0046813	biological_process	receptor-mediated virion attachment to host cell
B	0048018	molecular_function	receptor ligand activity
B	0052031	biological_process	symbiont-mediated perturbation of host defense response
B	0052170	biological_process	symbiont-mediated suppression of host innate immune response
B	0055036	cellular_component	virion membrane
B	0061025	biological_process	membrane fusion
B	0075509	biological_process	endocytosis involved in viral entry into host cell
B	0098670	biological_process	entry receptor-mediated virion attachment to host cell
B	0141146	biological_process	symbiont-mediated disruption of host tissue

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ

Chain	Residue	Details
A	THR370-GLN379

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Region: {"description":"Integrin-binding motif;","evidences":[{"source":"PubMed","id":"33102950","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Region: {"description":"Immunodominant HLA epitope recognized by the CD8+; called NF9 peptide","evidences":[{"source":"PubMed","id":"34171266","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32155444","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32363391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32366695","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32979942","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---