8XXY
Structure of CXCR3 in the apo-state (Receptor focused map)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| R | 0001525 | biological_process | angiogenesis |
| R | 0002685 | biological_process | regulation of leukocyte migration |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0004950 | molecular_function | chemokine receptor activity |
| R | 0005515 | molecular_function | protein binding |
| R | 0005737 | cellular_component | cytoplasm |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0006915 | biological_process | apoptotic process |
| R | 0006935 | biological_process | chemotaxis |
| R | 0006954 | biological_process | inflammatory response |
| R | 0006955 | biological_process | immune response |
| R | 0007155 | biological_process | cell adhesion |
| R | 0007165 | biological_process | signal transduction |
| R | 0007166 | biological_process | cell surface receptor signaling pathway |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| R | 0009897 | cellular_component | external side of plasma membrane |
| R | 0009986 | cellular_component | cell surface |
| R | 0010818 | biological_process | T cell chemotaxis |
| R | 0016020 | cellular_component | membrane |
| R | 0016493 | molecular_function | C-C chemokine receptor activity |
| R | 0016494 | molecular_function | C-X-C chemokine receptor activity |
| R | 0019722 | biological_process | calcium-mediated signaling |
| R | 0019956 | molecular_function | chemokine binding |
| R | 0019957 | molecular_function | C-C chemokine binding |
| R | 0030155 | biological_process | regulation of cell adhesion |
| R | 0060326 | biological_process | cell chemotaxis |
| R | 0070098 | biological_process | chemokine-mediated signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. AGAlLLACISFDRYLnI |
| Chain | Residue | Details |
| R | ALA137-ILE153 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 29 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
