8XXQ
Structural of methylmalonate semialdehyde dehydrogenase ALDH6A1
Functional Information from PROSITE/UniProt
| site_id | PS00070 |
| Number of Residues | 12 |
| Details | ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FgAAGQRCMALS |
| Chain | Residue | Details |
| A | PHE278-SER289 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10008 |
| Chain | Residue | Details |
| A | CYS285 | |
| B | CYS285 | |
| C | CYS285 | |
| D | CYS285 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P42412 |
| Chain | Residue | Details |
| A | ALA151 | |
| B | LYS177 | |
| B | GLU180 | |
| B | ARG181 | |
| B | SER230 | |
| B | GLU385 | |
| C | ALA151 | |
| C | PHE153 | |
| C | LYS177 | |
| C | GLU180 | |
| C | ARG181 | |
| A | PHE153 | |
| C | SER230 | |
| C | GLU385 | |
| D | ALA151 | |
| D | PHE153 | |
| D | LYS177 | |
| D | GLU180 | |
| D | ARG181 | |
| D | SER230 | |
| D | GLU385 | |
| A | LYS177 | |
| A | GLU180 | |
| A | ARG181 | |
| A | SER230 | |
| A | GLU385 | |
| B | ALA151 | |
| B | PHE153 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9EQ20 |
| Chain | Residue | Details |
| A | LYS15 | |
| B | LYS20 | |
| B | LYS23 | |
| B | LYS44 | |
| B | LYS85 | |
| B | LYS97 | |
| B | LYS332 | |
| B | LYS344 | |
| C | LYS15 | |
| C | LYS20 | |
| C | LYS23 | |
| A | LYS20 | |
| C | LYS44 | |
| C | LYS85 | |
| C | LYS97 | |
| C | LYS332 | |
| C | LYS344 | |
| D | LYS15 | |
| D | LYS20 | |
| D | LYS23 | |
| D | LYS44 | |
| D | LYS85 | |
| A | LYS23 | |
| D | LYS97 | |
| D | LYS332 | |
| D | LYS344 | |
| A | LYS44 | |
| A | LYS85 | |
| A | LYS97 | |
| A | LYS332 | |
| A | LYS344 | |
| B | LYS15 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9EQ20 |
| Chain | Residue | Details |
| A | LYS55 | |
| B | LYS468 | |
| C | LYS55 | |
| C | LYS266 | |
| C | LYS298 | |
| C | LYS299 | |
| C | LYS468 | |
| D | LYS55 | |
| D | LYS266 | |
| D | LYS298 | |
| D | LYS299 | |
| A | LYS266 | |
| D | LYS468 | |
| A | LYS298 | |
| A | LYS299 | |
| A | LYS468 | |
| B | LYS55 | |
| B | LYS266 | |
| B | LYS298 | |
| B | LYS299 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER230 | |
| A | SER348 | |
| B | SER230 | |
| B | SER348 | |
| C | SER230 | |
| C | SER348 | |
| D | SER230 | |
| D | SER348 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9EQ20 |
| Chain | Residue | Details |
| A | LYS359 | |
| A | LYS485 | |
| B | LYS359 | |
| B | LYS485 | |
| C | LYS359 | |
| C | LYS485 | |
| D | LYS359 | |
| D | LYS485 |
