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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8XX7

Structure of CXCR2 bound to CXCL5 (CXCR2-CXCL5-Go Full map)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006935biological_processchemotaxis
B0006952biological_processdefense response
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0007165biological_processsignal transduction
B0007267biological_processcell-cell signaling
B0008009molecular_functionchemokine activity
B0008284biological_processpositive regulation of cell population proliferation
B0030593biological_processneutrophil chemotaxis
B0042802molecular_functionidentical protein binding
B0045236molecular_functionCXCR chemokine receptor binding
B0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
B0071222biological_processcellular response to lipopolysaccharide
C0002407biological_processdendritic cell chemotaxis
C0004918molecular_functioninterleukin-8 receptor activity
C0004930molecular_functionG protein-coupled receptor activity
C0004950molecular_functionchemokine receptor activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006935biological_processchemotaxis
C0006954biological_processinflammatory response
C0006955biological_processimmune response
C0006968biological_processcellular defense response
C0007165biological_processsignal transduction
C0007166biological_processcell surface receptor signaling pathway
C0007186biological_processG protein-coupled receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0008284biological_processpositive regulation of cell population proliferation
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0016020cellular_componentmembrane
C0016493molecular_functionC-C chemokine receptor activity
C0016494molecular_functionC-X-C chemokine receptor activity
C0019722biological_processcalcium-mediated signaling
C0019957molecular_functionC-C chemokine binding
C0019959molecular_functioninterleukin-8 binding
C0030593biological_processneutrophil chemotaxis
C0030667cellular_componentsecretory granule membrane
C0031623biological_processreceptor internalization
C0038112biological_processinterleukin-8-mediated signaling pathway
C0042119biological_processneutrophil activation
C0042629cellular_componentmast cell granule
C0050920biological_processregulation of chemotaxis
C0070098biological_processchemokine-mediated signaling pathway
D0005125molecular_functioncytokine activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006935biological_processchemotaxis
D0006952biological_processdefense response
D0006954biological_processinflammatory response
D0006955biological_processimmune response
D0007165biological_processsignal transduction
D0007267biological_processcell-cell signaling
D0008009molecular_functionchemokine activity
D0008284biological_processpositive regulation of cell population proliferation
D0030593biological_processneutrophil chemotaxis
D0042802molecular_functionidentical protein binding
D0045236molecular_functionCXCR chemokine receptor binding
D0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
D0071222biological_processcellular response to lipopolysaccharide
E0001750cellular_componentphotoreceptor outer segment
E0003924molecular_functionGTPase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005765cellular_componentlysosomal membrane
E0005829cellular_componentcytosol
E0005834cellular_componentheterotrimeric G-protein complex
E0005886cellular_componentplasma membrane
E0007165biological_processsignal transduction
E0007186biological_processG protein-coupled receptor signaling pathway
E0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
E0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
E0007265biological_processRas protein signal transduction
E0016020cellular_componentmembrane
E0030159molecular_functionsignaling receptor complex adaptor activity
E0044877molecular_functionprotein-containing complex binding
E0045202cellular_componentsynapse
E0051020molecular_functionGTPase binding
E0070062cellular_componentextracellular exosome
E0071380biological_processcellular response to prostaglandin E stimulus
E0071870biological_processcellular response to catecholamine stimulus
E0097381cellular_componentphotoreceptor disc membrane
E1903561cellular_componentextracellular vesicle
F0003924molecular_functionGTPase activity
F0005525molecular_functionGTP binding
F0007186biological_processG protein-coupled receptor signaling pathway
F0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
F0019001molecular_functionguanyl nucleotide binding
F0031683molecular_functionG-protein beta/gamma-subunit complex binding
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0045202cellular_componentsynapse
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
H0001750cellular_componentphotoreceptor outer segment
H0003924molecular_functionGTPase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005765cellular_componentlysosomal membrane
H0005829cellular_componentcytosol
H0005834cellular_componentheterotrimeric G-protein complex
H0005886cellular_componentplasma membrane
H0007165biological_processsignal transduction
H0007186biological_processG protein-coupled receptor signaling pathway
H0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
H0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
H0007265biological_processRas protein signal transduction
H0016020cellular_componentmembrane
H0030159molecular_functionsignaling receptor complex adaptor activity
H0044877molecular_functionprotein-containing complex binding
H0045202cellular_componentsynapse
H0051020molecular_functionGTPase binding
H0070062cellular_componentextracellular exosome
H0071380biological_processcellular response to prostaglandin E stimulus
H0071870biological_processcellular response to catecholamine stimulus
H0097381cellular_componentphotoreceptor disc membrane
H1903561cellular_componentextracellular vesicle
I0005515molecular_functionprotein binding
I0005834cellular_componentheterotrimeric G-protein complex
I0005886cellular_componentplasma membrane
I0007165biological_processsignal transduction
I0007186biological_processG protein-coupled receptor signaling pathway
I0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
I0016020cellular_componentmembrane
I0031681molecular_functionG-protein beta-subunit binding
I0045202cellular_componentsynapse
I0070062cellular_componentextracellular exosome
I0071380biological_processcellular response to prostaglandin E stimulus
I0071870biological_processcellular response to catecholamine stimulus
R0002407biological_processdendritic cell chemotaxis
R0004918molecular_functioninterleukin-8 receptor activity
R0004930molecular_functionG protein-coupled receptor activity
R0004950molecular_functionchemokine receptor activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0006935biological_processchemotaxis
R0006954biological_processinflammatory response
R0006955biological_processimmune response
R0006968biological_processcellular defense response
R0007165biological_processsignal transduction
R0007166biological_processcell surface receptor signaling pathway
R0007186biological_processG protein-coupled receptor signaling pathway
R0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0008284biological_processpositive regulation of cell population proliferation
R0009897cellular_componentexternal side of plasma membrane
R0009986cellular_componentcell surface
R0016020cellular_componentmembrane
R0016493molecular_functionC-C chemokine receptor activity
R0016494molecular_functionC-X-C chemokine receptor activity
R0019722biological_processcalcium-mediated signaling
R0019957molecular_functionC-C chemokine binding
R0019959molecular_functioninterleukin-8 binding
R0030593biological_processneutrophil chemotaxis
R0030667cellular_componentsecretory granule membrane
R0031623biological_processreceptor internalization
R0038112biological_processinterleukin-8-mediated signaling pathway
R0042119biological_processneutrophil activation
R0042629cellular_componentmast cell granule
R0050920biological_processregulation of chemotaxis
R0070098biological_processchemokine-mediated signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SGIlLLACISVDRYLaI
ChainResidueDetails
RSER132-ILE148
site_idPS00471
Number of Residues45
DetailsSMALL_CYTOKINES_CXC Small cytokines (intercrine/chemokine) C-x-C subfamily signature. CvCLqttqg.VhpKmIsnLqvfaiGpqCskvEVVaslkngkei.CLD
ChainResidueDetails
DCYS13-ASP57
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
ELEU70-SER84
EILE157-ILE171
ELEU285-ALA299
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues52
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues94
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues116
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues38
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsSite: {"description":"(Microbial infection) Cleavage; by Staphylococcus aureus/SspP","evidences":[{"source":"PubMed","id":"22850671","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues26
DetailsRegion: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues18
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues14
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues10
DetailsRegion: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P18872","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsModified residue: {"description":"5-glutamyl histamine","evidences":[{"source":"UniProtKB","id":"P18872","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"ADP-ribosylcysteine; by pertussis toxin","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"33408414","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues96
DetailsRepeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues90
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues80
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues82
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues86
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues82
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues60
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues2
DetailsModified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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