Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8XWS

Structure of CXCR2 bound to CXCL5 (Ligand-receptor focused map)

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006935	biological_process	chemotaxis
B	0006952	biological_process	defense response
B	0006954	biological_process	inflammatory response
B	0006955	biological_process	immune response
B	0007165	biological_process	signal transduction
B	0007267	biological_process	cell-cell signaling
B	0008009	molecular_function	chemokine activity
B	0008284	biological_process	positive regulation of cell population proliferation
B	0030593	biological_process	neutrophil chemotaxis
B	0042802	molecular_function	identical protein binding
B	0045236	molecular_function	CXCR chemokine receptor binding
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	0071222	biological_process	cellular response to lipopolysaccharide
C	0002407	biological_process	dendritic cell chemotaxis
C	0004918	molecular_function	interleukin-8 receptor activity
C	0004930	molecular_function	G protein-coupled receptor activity
C	0004950	molecular_function	chemokine receptor activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006935	biological_process	chemotaxis
C	0006954	biological_process	inflammatory response
C	0006955	biological_process	immune response
C	0006968	biological_process	cellular defense response
C	0007165	biological_process	signal transduction
C	0007166	biological_process	cell surface receptor signaling pathway
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
C	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
C	0008284	biological_process	positive regulation of cell population proliferation
C	0009897	cellular_component	external side of plasma membrane
C	0009986	cellular_component	cell surface
C	0016020	cellular_component	membrane
C	0016493	molecular_function	C-C chemokine receptor activity
C	0016494	molecular_function	C-X-C chemokine receptor activity
C	0019722	biological_process	calcium-mediated signaling
C	0019957	molecular_function	C-C chemokine binding
C	0019959	molecular_function	interleukin-8 binding
C	0030593	biological_process	neutrophil chemotaxis
C	0030667	cellular_component	secretory granule membrane
C	0031623	biological_process	receptor internalization
C	0038112	biological_process	interleukin-8-mediated signaling pathway
C	0042119	biological_process	neutrophil activation
C	0042629	cellular_component	mast cell granule
C	0050920	biological_process	regulation of chemotaxis
C	0070098	biological_process	chemokine-mediated signaling pathway
D	0005125	molecular_function	cytokine activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006935	biological_process	chemotaxis
D	0006952	biological_process	defense response
D	0006954	biological_process	inflammatory response
D	0006955	biological_process	immune response
D	0007165	biological_process	signal transduction
D	0007267	biological_process	cell-cell signaling
D	0008009	molecular_function	chemokine activity
D	0008284	biological_process	positive regulation of cell population proliferation
D	0030593	biological_process	neutrophil chemotaxis
D	0042802	molecular_function	identical protein binding
D	0045236	molecular_function	CXCR chemokine receptor binding
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
D	0071222	biological_process	cellular response to lipopolysaccharide
R	0002407	biological_process	dendritic cell chemotaxis
R	0004918	molecular_function	interleukin-8 receptor activity
R	0004930	molecular_function	G protein-coupled receptor activity
R	0004950	molecular_function	chemokine receptor activity
R	0005515	molecular_function	protein binding
R	0005886	cellular_component	plasma membrane
R	0006935	biological_process	chemotaxis
R	0006954	biological_process	inflammatory response
R	0006955	biological_process	immune response
R	0006968	biological_process	cellular defense response
R	0007165	biological_process	signal transduction
R	0007166	biological_process	cell surface receptor signaling pathway
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
R	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
R	0008284	biological_process	positive regulation of cell population proliferation
R	0009897	cellular_component	external side of plasma membrane
R	0009986	cellular_component	cell surface
R	0016020	cellular_component	membrane
R	0016493	molecular_function	C-C chemokine receptor activity
R	0016494	molecular_function	C-X-C chemokine receptor activity
R	0019722	biological_process	calcium-mediated signaling
R	0019957	molecular_function	C-C chemokine binding
R	0019959	molecular_function	interleukin-8 binding
R	0030593	biological_process	neutrophil chemotaxis
R	0030667	cellular_component	secretory granule membrane
R	0031623	biological_process	receptor internalization
R	0038112	biological_process	interleukin-8-mediated signaling pathway
R	0042119	biological_process	neutrophil activation
R	0042629	cellular_component	mast cell granule
R	0050920	biological_process	regulation of chemotaxis
R	0070098	biological_process	chemokine-mediated signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SGIlLLACISVDRYLaI

Chain	Residue	Details
R	SER132-ILE148

site_id	PS00471
Number of Residues	45
Details	SMALL_CYTOKINES_CXC Small cytokines (intercrine/chemokine) C-x-C subfamily signature. CvCLqttqg.VhpKmIsnLqvfaiGpqCskvEVVaslkngkei.CLD

Chain	Residue	Details
D	CYS13-ASP57

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	52
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	94
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	116
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Site: {"description":"(Microbial infection) Cleavage; by Staphylococcus aureus/SspP","evidences":[{"source":"PubMed","id":"22850671","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)