8XWN

Structure of CXCR2 bound to CXCL8 (Ligand-receptor focused map)

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0001525	biological_process	angiogenesis
D	0002237	biological_process	response to molecule of bacterial origin
D	0005125	molecular_function	cytokine activity
D	0005153	molecular_function	interleukin-8 receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006935	biological_process	chemotaxis
D	0006952	biological_process	defense response
D	0006954	biological_process	inflammatory response
D	0006955	biological_process	immune response
D	0007165	biological_process	signal transduction
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
D	0008009	molecular_function	chemokine activity
D	0008201	molecular_function	heparin binding
D	0008285	biological_process	negative regulation of cell population proliferation
D	0010628	biological_process	positive regulation of gene expression
D	0010629	biological_process	negative regulation of gene expression
D	0016020	cellular_component	membrane
D	0019722	biological_process	calcium-mediated signaling
D	0030155	biological_process	regulation of cell adhesion
D	0030593	biological_process	neutrophil chemotaxis
D	0031623	biological_process	receptor internalization
D	0032642	biological_process	regulation of chemokine production
D	0034976	biological_process	response to endoplasmic reticulum stress
D	0035556	biological_process	intracellular signal transduction
D	0042119	biological_process	neutrophil activation
D	0044344	biological_process	cellular response to fibroblast growth factor stimulus
D	0045091	biological_process	regulation of single stranded viral RNA replication via double stranded DNA intermediate
D	0045236	molecular_function	CXCR chemokine receptor binding
D	0045730	biological_process	respiratory burst
D	0045744	biological_process	negative regulation of G protein-coupled receptor signaling pathway
D	0045766	biological_process	positive regulation of angiogenesis
D	0048566	biological_process	embryonic digestive tract development
D	0050920	biological_process	regulation of chemotaxis
D	0050930	biological_process	induction of positive chemotaxis
D	0060354	biological_process	negative regulation of cell adhesion molecule production
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
D	0071222	biological_process	cellular response to lipopolysaccharide
D	0071347	biological_process	cellular response to interleukin-1
D	0071356	biological_process	cellular response to tumor necrosis factor
D	0090023	biological_process	positive regulation of neutrophil chemotaxis
D	2000535	biological_process	regulation of entry of bacterium into host cell
E	0001525	biological_process	angiogenesis
E	0002237	biological_process	response to molecule of bacterial origin
E	0005125	molecular_function	cytokine activity
E	0005153	molecular_function	interleukin-8 receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006935	biological_process	chemotaxis
E	0006952	biological_process	defense response
E	0006954	biological_process	inflammatory response
E	0006955	biological_process	immune response
E	0007165	biological_process	signal transduction
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
E	0008009	molecular_function	chemokine activity
E	0008201	molecular_function	heparin binding
E	0008285	biological_process	negative regulation of cell population proliferation
E	0010628	biological_process	positive regulation of gene expression
E	0010629	biological_process	negative regulation of gene expression
E	0016020	cellular_component	membrane
E	0019722	biological_process	calcium-mediated signaling
E	0030155	biological_process	regulation of cell adhesion
E	0030593	biological_process	neutrophil chemotaxis
E	0031623	biological_process	receptor internalization
E	0032642	biological_process	regulation of chemokine production
E	0034976	biological_process	response to endoplasmic reticulum stress
E	0035556	biological_process	intracellular signal transduction
E	0042119	biological_process	neutrophil activation
E	0044344	biological_process	cellular response to fibroblast growth factor stimulus
E	0045091	biological_process	regulation of single stranded viral RNA replication via double stranded DNA intermediate
E	0045236	molecular_function	CXCR chemokine receptor binding
E	0045730	biological_process	respiratory burst
E	0045744	biological_process	negative regulation of G protein-coupled receptor signaling pathway
E	0045766	biological_process	positive regulation of angiogenesis
E	0048566	biological_process	embryonic digestive tract development
E	0050920	biological_process	regulation of chemotaxis
E	0050930	biological_process	induction of positive chemotaxis
E	0060354	biological_process	negative regulation of cell adhesion molecule production
E	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0071222	biological_process	cellular response to lipopolysaccharide
E	0071347	biological_process	cellular response to interleukin-1
E	0071356	biological_process	cellular response to tumor necrosis factor
E	0090023	biological_process	positive regulation of neutrophil chemotaxis
E	2000535	biological_process	regulation of entry of bacterium into host cell
R	0002407	biological_process	dendritic cell chemotaxis
R	0004918	molecular_function	interleukin-8 receptor activity
R	0004930	molecular_function	G protein-coupled receptor activity
R	0004950	molecular_function	chemokine receptor activity
R	0005515	molecular_function	protein binding
R	0005886	cellular_component	plasma membrane
R	0006935	biological_process	chemotaxis
R	0006954	biological_process	inflammatory response
R	0006955	biological_process	immune response
R	0006968	biological_process	cellular defense response
R	0007165	biological_process	signal transduction
R	0007166	biological_process	cell surface receptor signaling pathway
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
R	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
R	0008284	biological_process	positive regulation of cell population proliferation
R	0009897	cellular_component	external side of plasma membrane
R	0009986	cellular_component	cell surface
R	0016020	cellular_component	membrane
R	0016493	molecular_function	C-C chemokine receptor activity
R	0016494	molecular_function	C-X-C chemokine receptor activity
R	0019722	biological_process	calcium-mediated signaling
R	0019957	molecular_function	C-C chemokine binding
R	0019959	molecular_function	interleukin-8 binding
R	0030593	biological_process	neutrophil chemotaxis
R	0030667	cellular_component	secretory granule membrane
R	0031623	biological_process	receptor internalization
R	0038112	biological_process	interleukin-8-mediated signaling pathway
R	0042119	biological_process	neutrophil activation
R	0042629	cellular_component	mast cell granule
R	0050920	biological_process	regulation of chemotaxis
R	0070098	biological_process	chemokine-mediated signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SGIlLLACISVDRYLaI

Chain	Residue	Details
R	SER132-ILE148

---

site_id	PS00471
Number of Residues	46
Details	SMALL_CYTOKINES_CXC Small cytokines (intercrine/chemokine) C-x-C subfamily signature. CqCIktyskpFhpKfIkeLrviesGphCantEIIvklsdgrel.CLD

Chain	Residue	Details
D	CYS14-ASP59

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	47
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	58
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Site: {"description":"(Microbial infection) Cleavage; by Staphylococcus aureus/SspP","evidences":[{"source":"PubMed","id":"22850671","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Site: {"description":"Cleavage; by thrombin","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Site: {"description":"Cleavage; by MMP9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Citrulline","evidences":[{"source":"PubMed","id":"18710930","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608678","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---