8XWF
Structure of CXCR2 bound to CXCL3 (Ligand-receptor focused map)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| D | 0005576 | cellular_component | extracellular region |
| D | 0006935 | biological_process | chemotaxis |
| D | 0006952 | biological_process | defense response |
| D | 0006955 | biological_process | immune response |
| D | 0008009 | molecular_function | chemokine activity |
| D | 0030593 | biological_process | neutrophil chemotaxis |
| E | 0005576 | cellular_component | extracellular region |
| E | 0006935 | biological_process | chemotaxis |
| E | 0006952 | biological_process | defense response |
| E | 0006955 | biological_process | immune response |
| E | 0008009 | molecular_function | chemokine activity |
| E | 0030593 | biological_process | neutrophil chemotaxis |
| R | 0002407 | biological_process | dendritic cell chemotaxis |
| R | 0004918 | molecular_function | interleukin-8 receptor activity |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0004950 | molecular_function | chemokine receptor activity |
| R | 0005515 | molecular_function | protein binding |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0006935 | biological_process | chemotaxis |
| R | 0006954 | biological_process | inflammatory response |
| R | 0006955 | biological_process | immune response |
| R | 0006968 | biological_process | cellular defense response |
| R | 0007165 | biological_process | signal transduction |
| R | 0007166 | biological_process | cell surface receptor signaling pathway |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| R | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| R | 0008284 | biological_process | positive regulation of cell population proliferation |
| R | 0009897 | cellular_component | external side of plasma membrane |
| R | 0009986 | cellular_component | cell surface |
| R | 0016020 | cellular_component | membrane |
| R | 0016493 | molecular_function | C-C chemokine receptor activity |
| R | 0016494 | molecular_function | C-X-C chemokine receptor activity |
| R | 0019722 | biological_process | calcium-mediated signaling |
| R | 0019957 | molecular_function | C-C chemokine binding |
| R | 0019959 | molecular_function | interleukin-8 binding |
| R | 0030593 | biological_process | neutrophil chemotaxis |
| R | 0030667 | cellular_component | secretory granule membrane |
| R | 0031623 | biological_process | receptor internalization |
| R | 0038112 | biological_process | interleukin-8-mediated signaling pathway |
| R | 0042119 | biological_process | neutrophil activation |
| R | 0042629 | cellular_component | mast cell granule |
| R | 0050920 | biological_process | regulation of chemotaxis |
| R | 0070098 | biological_process | chemokine-mediated signaling pathway |
| R | 0097648 | cellular_component | G protein-coupled receptor complex |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SGIlLLACISVDRYLaI |
| Chain | Residue | Details |
| R | SER132-ILE148 |
| site_id | PS00471 |
| Number of Residues | 45 |
| Details | SMALL_CYTOKINES_CXC Small cytokines (intercrine/chemokine) C-x-C subfamily signature. CqCLqtlqg.IhlKnIqsVnvrspGphCaqtEVIatlkngkka.CLN |
| Chain | Residue | Details |
| E | CYS9-ASN53 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 47 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 58 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by Staphylococcus aureus/SspP","evidences":[{"source":"PubMed","id":"22850671","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
