8XW4
Cryo-EM structure of TMEM63B-Digitonin state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005227 | molecular_function | calcium-activated cation channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007605 | biological_process | sensory perception of sound |
| A | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| A | 0015629 | cellular_component | actin cytoskeleton |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0097233 | cellular_component | alveolar lamellar body membrane |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 0140135 | molecular_function | mechanosensitive monoatomic cation channel activity |
| A | 0160069 | biological_process | surfactant secretion |
| A | 1990760 | molecular_function | osmolarity-sensing monoatomic cation channel activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 200 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL41-ILE61 | |
| A | MET711-GLY731 | |
| A | ILE158-PHE178 | |
| A | ASN203-MET223 | |
| A | LEU435-ILE455 | |
| A | THR481-PHE501 | |
| A | PHE521-PHE541 | |
| A | VAL560-GLY580 | |
| A | VAL630-MET650 | |
| A | SER678-PHE698 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER111 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q3TWI9 |
| Chain | Residue | Details |
| A | SER113 | |
| A | SER115 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER114 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | ASN462 |
