8XW1
Cryo-EM structure of OSCA1.2-V335W-DDM state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005227 | molecular_function | calcium-activated cation channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS01319 |
| Number of Residues | 22 |
| Details | RBFA Ribosome-binding factor A signature. VQSlAtiegi.VKaAPFLkFivD |
| Chain | Residue | Details |
| A | VAL396-ASP417 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=TM0","evidences":[{"source":"PubMed","id":"30498218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"30498218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38103547","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 262 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30498218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38103547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30382939","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6IJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"30498218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38103547","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"30498218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38103547","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"30498218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38103547","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"30498218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38103547","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"30498218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38103547","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30498218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38103547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30382939","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6IJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 15 |
| Details | Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"30498218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38103547","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"30498218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38103547","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"30498218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38103547","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
