8XV5
Pyridoxamine-bound human SLC19A3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| A | 0015234 | molecular_function | thiamine transmembrane transporter activity |
| A | 0015888 | biological_process | thiamine transport |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0031923 | biological_process | pyridoxine transport |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0042723 | biological_process | thiamine-containing compound metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051180 | biological_process | vitamin transport |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071934 | biological_process | thiamine transmembrane transport |
| A | 0090482 | molecular_function | vitamin transmembrane transporter activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 64 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 220 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | Site: {"description":"Essential for pyridoxine transport","evidences":[{"source":"PubMed","id":"35724964","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
