8XSY
Cryo-EM structure of the human 80S ribosome with Tigecycline, e-tRNA and CCDC124 (40S head Swivelled)
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
site_id | PS00049 |
Number of Residues | 27 |
Details | RIBOSOMAL_L14 Ribosomal protein L14 signature. AVVIrqrksyrrk.DGvflyFedNagVI |
Chain | Residue | Details |
LV | ALA79-ILE105 |
site_id | PS00050 |
Number of Residues | 16 |
Details | RIBOSOMAL_L23 Ribosomal protein L23 signature. KKAYVRLApdydaldV |
Chain | Residue | Details |
LX | LYS134-VAL149 |
site_id | PS00051 |
Number of Residues | 17 |
Details | RIBOSOMAL_L39E Ribosomal protein L39e signature. KTgnkIryNskrRHWRR |
Chain | Residue | Details |
Ll | LYS30-ARG46 |
site_id | PS00052 |
Number of Residues | 27 |
Details | RIBOSOMAL_S7 Ribosomal protein S7 signature. ErLtnsMMmhgrnnGKKlmtvrIVkhA |
Chain | Residue | Details |
SF | GLU70-ALA96 |
site_id | PS00053 |
Number of Residues | 18 |
Details | RIBOSOMAL_S8 Ribosomal protein S8 signature. GfiVLTTSaGIMdheeAR |
Chain | Residue | Details |
SW | GLY100-ARG117 |
site_id | PS00054 |
Number of Residues | 23 |
Details | RIBOSOMAL_S11 Ribosomal protein S11 signature. LrALarS.GMkIgrieDvTPiPSD |
Chain | Residue | Details |
SO | LEU116-ASP138 |
site_id | PS00055 |
Number of Residues | 8 |
Details | RIBOSOMAL_S12 Ribosomal protein S12 signature. KqPNSAiR |
Chain | Residue | Details |
SX | LYS60-ARG67 |
site_id | PS00056 |
Number of Residues | 13 |
Details | RIBOSOMAL_S17 Ribosomal protein S17 signature. GDiVtVgEcRPLS |
Chain | Residue | Details |
SL | GLY123-SER135 |
site_id | PS00299 |
Number of Residues | 26 |
Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
Chain | Residue | Details |
Sf | LYS27-ASP52 | |
Lm | LYS27-ASP52 |
site_id | PS00323 |
Number of Residues | 25 |
Details | RIBOSOMAL_S19 Ribosomal protein S19 signature. NGKtfnqveIkpemIGhyLGEFsiT |
Chain | Residue | Details |
SP | ASN98-THR122 |
site_id | PS00358 |
Number of Residues | 17 |
Details | RIBOSOMAL_L5 Ribosomal protein L5 signature. LeqLTGQtpVfSkARyT |
Chain | Residue | Details |
LJ | LEU40-THR56 |
site_id | PS00359 |
Number of Residues | 16 |
Details | RIBOSOMAL_L11 Ribosomal protein L11 signature. KeIlGTaqSVGcNVdG |
Chain | Residue | Details |
Lt | LYS130-GLY145 |
site_id | PS00360 |
Number of Residues | 19 |
Details | RIBOSOMAL_S9 Ribosomal protein S9 signature. GGGhvAQiyAirqSiSKAL |
Chain | Residue | Details |
SQ | GLY74-LEU92 |
site_id | PS00361 |
Number of Residues | 16 |
Details | RIBOSOMAL_S10 Ribosomal protein S10 signature. AkekNLkvkGPVrMPT |
Chain | Residue | Details |
SU | ALA43-THR58 |
site_id | PS00362 |
Number of Residues | 31 |
Details | RIBOSOMAL_S15 Ribosomal protein S15 signature. VrkHLernRkDkdAkfrLilIesrihrLarY |
Chain | Residue | Details |
SN | VAL98-TYR128 |
site_id | PS00464 |
Number of Residues | 25 |
Details | RIBOSOMAL_L22 Ribosomal protein L22 signature. RrrTyRAhGRinpymsspCHIEMiL |
Chain | Residue | Details |
LP | ARG126-LEU150 |
site_id | PS00467 |
Number of Residues | 12 |
Details | RIBOSOMAL_L2 Ribosomal protein L2 signature. PrvRGVAmNPvE |
Chain | Residue | Details |
LA | PRO197-GLU208 |
site_id | PS00474 |
Number of Residues | 24 |
Details | RIBOSOMAL_L3 Ribosomal protein L3 signature. FgqdemiDviGvTkGKGykGvtsR |
Chain | Residue | Details |
LB | PHE211-ARG234 |
site_id | PS00475 |
Number of Residues | 32 |
Details | RIBOSOMAL_L15 Ribosomal protein L15 signature. KVLGkGkLpkqp.ViVkakfFSrrAeekIksvG |
Chain | Residue | Details |
La | LYS110-GLY141 |
site_id | PS00526 |
Number of Residues | 20 |
Details | RIBOSOMAL_L19E Ribosomal protein L19e signature. QKRLaSsvlrCGkkkVWLDP |
Chain | Residue | Details |
LR | GLN7-PRO26 |
site_id | PS00527 |
Number of Residues | 23 |
Details | RIBOSOMAL_S14 Ribosomal protein S14 signature. RvCsnrhglirkyg.LNMCRqCFR |
Chain | Residue | Details |
Sd | ARG22-ARG44 |
site_id | PS00528 |
Number of Residues | 15 |
Details | RIBOSOMAL_S4E Ribosomal protein S4e signature. HlKRVAaPkhWmLdK |
Chain | Residue | Details |
SE | HIS8-LYS22 |
site_id | PS00529 |
Number of Residues | 23 |
Details | RIBOSOMAL_S24E Ribosomal protein S24e signature. FGggKTtGFGmIYDSldyakknE |
Chain | Residue | Details |
SY | PHE64-GLU86 |
site_id | PS00548 |
Number of Residues | 37 |
Details | RIBOSOMAL_S3 Ribosomal protein S3 signature. AKsmkfvdGlMihSgdpVnyyVDtavrhvlLrqGvlG |
Chain | Residue | Details |
SD | ALA147-GLY183 |
site_id | PS00578 |
Number of Residues | 12 |
Details | RIBOSOMAL_S6E Ribosomal protein S6e signature. ISGGnDkqGfPM |
Chain | Residue | Details |
SG | ILE52-MET63 |
site_id | PS00579 |
Number of Residues | 15 |
Details | RIBOSOMAL_L29 Ribosomal protein L29 signature. KLSKIRvVRKSIARV |
Chain | Residue | Details |
Lh | LYS43-VAL57 |
site_id | PS00580 |
Number of Residues | 21 |
Details | RIBOSOMAL_L32E Ribosomal protein L32e signature. FiRhqsdRyvKIkrn..WRKprG |
Chain | Residue | Details |
Le | PHE20-GLY40 |
site_id | PS00585 |
Number of Residues | 33 |
Details | RIBOSOMAL_S5 Ribosomal protein S5 signature. GQrtrFkAfvAIGDyn.GhVGlGvkcsk.EVat.AI |
Chain | Residue | Details |
SC | GLY119-ILE151 |
site_id | PS00628 |
Number of Residues | 20 |
Details | RIBOSOMAL_S19E Ribosomal protein S19e signature. PshfsrgSksVaRrVLQaLE |
Chain | Residue | Details |
ST | PRO89-GLU108 |
site_id | PS00632 |
Number of Residues | 25 |
Details | RIBOSOMAL_S4 Ribosomal protein S4 signature. LErRLqtqVFKlglAkSihhARvLI |
Chain | Residue | Details |
SJ | LEU106-ILE130 |
site_id | PS00634 |
Number of Residues | 33 |
Details | RIBOSOMAL_L30 Ribosomal protein L30 signature. VLqlLrLrQifNgTfvklnkasinMLriVepYI |
Chain | Residue | Details |
LF | VAL108-ILE140 |
site_id | PS00646 |
Number of Residues | 14 |
Details | RIBOSOMAL_S13_1 Ribosomal protein S13 signature. RGlRHfwGlrVRGQ |
Chain | Residue | Details |
SS | ARG121-GLN134 |
site_id | PS00678 |
Number of Residues | 15 |
Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. ALSGswDgTLRLWDL |
Chain | Residue | Details |
Sg | ALA78-LEU92 | |
Sg | ILE120-THR134 | |
Sg | ILE165-LEU179 | |
Sg | CYS207-LEU221 |
site_id | PS00687 |
Number of Residues | 8 |
Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GESSGKNV |
Chain | Residue | Details |
LC | GLY15-VAL22 |
site_id | PS00700 |
Number of Residues | 22 |
Details | RIBOSOMAL_L6_2 Ribosomal protein L6 signature 2. QattVknKdiRkFlDGIYVseK |
Chain | Residue | Details |
LH | GLN163-LYS184 |
site_id | PS00709 |
Number of Residues | 25 |
Details | RIBOSOMAL_L30E_1 Ribosomal protein L30e signature 1. SgkyvlGyKqtLKmiRqGkaKlVIL |
Chain | Residue | Details |
Lc | SER24-LEU48 |
site_id | PS00712 |
Number of Residues | 16 |
Details | RIBOSOMAL_S17E Ribosomal protein S17e signature. IpSKkLRNkIAGYvTH |
Chain | Residue | Details |
SR | ILE41-HIS56 |
site_id | PS00733 |
Number of Residues | 8 |
Details | RIBOSOMAL_S26E Ribosomal protein S26e signature. YCVSCAIH |
Chain | Residue | Details |
Sa | TYR73-HIS80 |
site_id | PS00783 |
Number of Residues | 24 |
Details | RIBOSOMAL_L13 Ribosomal protein L13 signature. VRGMLPhktkrGQaaldrLkVFdG |
Chain | Residue | Details |
LO | VAL84-GLY107 |
site_id | PS00939 |
Number of Residues | 27 |
Details | RIBOSOMAL_L1E Ribosomal protein L1e signature. NttqKryAIcSALaASAlpalvmsKGH |
Chain | Residue | Details |
LC | ASN116-HIS142 |
site_id | PS00948 |
Number of Residues | 14 |
Details | RIBOSOMAL_S7E Ribosomal protein S7e signature. RLvRELEKKFSgKH |
Chain | Residue | Details |
SH | ARG78-HIS91 |
site_id | PS00961 |
Number of Residues | 9 |
Details | RIBOSOMAL_S28E Ribosomal protein S28e signature. ESEREARrL |
Chain | Residue | Details |
Sc | GLU60-LEU68 |
site_id | PS00962 |
Number of Residues | 12 |
Details | RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. VlKFLAAGTHLG |
Chain | Residue | Details |
SA | VAL15-GLY26 |
site_id | PS00963 |
Number of Residues | 25 |
Details | RIBOSOMAL_S2_2 Ribosomal protein S2 signature 2. PrlLVVtDpraDhqpLtEasyvNLP |
Chain | Residue | Details |
SA | PRO119-PRO143 |
site_id | PS00993 |
Number of Residues | 21 |
Details | RIBOSOMAL_L30E_2 Ribosomal protein L30e signature 2. ELGTacGKyyrvctLaIiDpG |
Chain | Residue | Details |
Lc | GLU80-GLY100 |
site_id | PS00996 |
Number of Residues | 9 |
Details | RIBOSOMAL_S21E Ribosomal protein S21e signature. LYVPRKCSA |
Chain | Residue | Details |
SV | LEU11-ALA19 |
site_id | PS01073 |
Number of Residues | 18 |
Details | RIBOSOMAL_L24E Ribosomal protein L24e signature. FsGykIyPGhGrrYaRtD |
Chain | Residue | Details |
LW | PHE8-ASP25 |
site_id | PS01077 |
Number of Residues | 20 |
Details | RIBOSOMAL_L37E Ribosomal protein L37e signature. GTsSfGkRrnkt.HtlCrRCG |
Chain | Residue | Details |
Lj | GLY4-GLY23 |
site_id | PS01082 |
Number of Residues | 18 |
Details | RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CrkmgVPYciIkGKarLG |
Chain | Residue | Details |
LG | CYS174-GLY191 |
site_id | PS01104 |
Number of Residues | 15 |
Details | RIBOSOMAL_L13E Ribosomal protein L13e signature. RaGRGFSLeELrvaG |
Chain | Residue | Details |
LL | ARG71-GLY85 |
site_id | PS01105 |
Number of Residues | 22 |
Details | RIBOSOMAL_L35AE Ribosomal protein L35Ae signature. GKVtRaHGnsGmVrAkFrsnLP |
Chain | Residue | Details |
Lf | GLY72-PRO93 |
site_id | PS01106 |
Number of Residues | 18 |
Details | RIBOSOMAL_L18E Ribosomal protein L18e signature. KrLfmSRtnRPpLSLsRM |
Chain | Residue | Details |
LQ | LYS49-MET66 |
site_id | PS01107 |
Number of Residues | 12 |
Details | RIBOSOMAL_L27E Ribosomal protein L27e signature. GKNkWFFqkLRF |
Chain | Residue | Details |
LZ | GLY125-PHE136 |
site_id | PS01108 |
Number of Residues | 19 |
Details | RIBOSOMAL_L24 Ribosomal protein L24 signature. DDeVqVVrGhyKGqqiGkV |
Chain | Residue | Details |
LY | ASP52-VAL70 |
site_id | PS01144 |
Number of Residues | 15 |
Details | RIBOSOMAL_L31E Ribosomal protein L31e signature. VRIDtrLNkAvWaKG |
Chain | Residue | Details |
Ld | VAL62-GLY76 |
site_id | PS01145 |
Number of Residues | 14 |
Details | RIBOSOMAL_L34E Ribosomal protein L34e signature. TaSnKtrlsRTPGN |
Chain | Residue | Details |
Lg | THR15-ASN28 |
site_id | PS01168 |
Number of Residues | 33 |
Details | RIBOSOMAL_S27E Ribosomal protein S27e signature. KCpgCykittvFShAqtvvlCvgCStvLcqPtG |
Chain | Residue | Details |
Sb | LYS36-GLY68 |
site_id | PS01170 |
Number of Residues | 19 |
Details | RIBOSOMAL_L6E Ribosomal protein L6e signature. NrvPLRRthqkFVIATSt.K |
Chain | Residue | Details |
LE | ASN182-LYS200 |
site_id | PS01171 |
Number of Residues | 26 |
Details | RIBOSOMAL_L21E Ribosomal protein L21e signature. GDiVdikgmgtvqk.GmpHkcYhGkTG |
Chain | Residue | Details |
LT | GLY37-GLY62 |
site_id | PS01172 |
Number of Residues | 12 |
Details | RIBOSOMAL_L44E Ribosomal protein L44e signature. KtTKKivLRleC |
Chain | Residue | Details |
Lo | LYS61-CYS72 |
site_id | PS01189 |
Number of Residues | 19 |
Details | RIBOSOMAL_S12E Ribosomal protein S12e signature. ALQevLktAlihDGLarGI |
Chain | Residue | Details |
SM | ALA17-ILE35 |
site_id | PS01190 |
Number of Residues | 11 |
Details | RIBOSOMAL_L36E Ribosomal protein L36e signature. PYERRaMELLK |
Chain | Residue | Details |
Li | PRO52-LYS62 |
site_id | PS01191 |
Number of Residues | 13 |
Details | RIBOSOMAL_S3AE Ribosomal protein S3Ae signature. LkGRVfEvSLaDL |
Chain | Residue | Details |
SB | LEU62-LEU74 |
site_id | PS01193 |
Number of Residues | 20 |
Details | RIBOSOMAL_S8E Ribosomal protein S8e signature. RrkTGGkrkpy.HkKrKyELG |
Chain | Residue | Details |
SI | ARG11-GLY30 |
site_id | PS01194 |
Number of Residues | 24 |
Details | RIBOSOMAL_L15E Ribosomal protein L15e signature. DKARrLGYkAkqGYVIYRiRVrRG |
Chain | Residue | Details |
LN | ASP46-GLY69 |
site_id | PS01199 |
Number of Residues | 20 |
Details | RIBOSOMAL_L1 Ribosomal protein L1 signature. IkqIpriLGpgLNKAGkFPS |
Chain | Residue | Details |
Lz | ILE117-SER136 |
site_id | PS01202 |
Number of Residues | 17 |
Details | MAP_2 Methionine aminopeptidase subfamily 2 signature. DLvKIDlGvHVDGfiaN |
Chain | Residue | Details |
CA | ASP104-ASN120 |
site_id | PS01257 |
Number of Residues | 22 |
Details | RIBOSOMAL_L10E Ribosomal protein L10e signature. ADRlqtGMRgAFGKPqGtvARV |
Chain | Residue | Details |
LI | ALA108-VAL129 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:12962325, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
LF | MET1 | |
LE | LYS207 | |
LR | ARG38 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
LF | THR17 | |
Sf | ARG72 | |
Sb | CYS56 | |
Sb | CYS59 | |
LA | LYS250 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
LF | LYS124 | |
CB | LYS122 | |
CB | LYS140 | |
LG | LYS21 | |
LG | LYS48 | |
LG | LYS125 | |
LG | LYS245 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P14148 |
Chain | Residue | Details |
LF | LYS127 | |
CB | ARG188 | |
SO | LYS63 | |
SO | LYS106 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
Chain | Residue | Details |
LF | TYR139 | |
SL | SER110 | |
SK | LYS139 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by MTOR => ECO:0000269|PubMed:36691768 |
Chain | Residue | Details |
CB | SER199 | |
SN | LYS43 | |
SD | ARG67 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
CB | SER203 | |
CB | SER205 | |
CB | SER208 | |
CB | SER221 | |
LB | LYS393 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
CB | LYS211 | |
SC | LYS275 | |
LW | LYS35 | |
LW | LYS147 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | MOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315 |
Chain | Residue | Details |
CB | ARG216 | |
CB | ARG364 | |
CB | ARG367 | |
CB | ARG370 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine; by MTOR => ECO:0000269|PubMed:36691768 |
Chain | Residue | Details |
CB | THR226 | |
Sf | LYS113 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:36691768, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
CB | SER234 | |
Sf | LYS48 |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9CY58 |
Chain | Residue | Details |
CB | LYS329 | |
LC | LYS364 |
site_id | SWS_FT_FI13 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
CB | SER330 |
site_id | SWS_FT_FI14 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
CB | SER392 | |
SD | LYS202 |
site_id | SWS_FT_FI15 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
CB | SER394 | |
SD | LYS230 |
site_id | SWS_FT_FI16 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate => ECO:0007744|PubMed:25114211 |
Chain | Residue | Details |
CB | LYS52 |
site_id | SWS_FT_FI17 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
Sf | LYS107 | |
CB | LYS281 |
site_id | SWS_FT_FI18 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
CB | LYS102 |
site_id | SWS_FT_FI19 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
CB | LYS211 |
site_id | SWS_FT_FI20 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
CB | LYS228 |