8XQJ
Cryo-EM structure of human dimeric APJR complex with antagonistic antibody
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0004930 | molecular_function | G protein-coupled receptor activity |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0016020 | cellular_component | membrane |
| C | 0020037 | molecular_function | heme binding |
| C | 0022900 | biological_process | electron transport chain |
| C | 0042597 | cellular_component | periplasmic space |
| D | 0004930 | molecular_function | G protein-coupled receptor activity |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| D | 0009055 | molecular_function | electron transfer activity |
| D | 0016020 | cellular_component | membrane |
| D | 0020037 | molecular_function | heme binding |
| D | 0022900 | biological_process | electron transport chain |
| D | 0042597 | cellular_component | periplasmic space |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVfCLTGLSFDRYLaI |
| Chain | Residue | Details |
| C | ALA115-ILE131 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 102 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 126 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 34 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Site: {"description":"Required for APELA and APLN/apelin-13 interaction and signaling","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38428423","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
