8XN5
Cryo-EM structure of SARS-CoV-2 Omicron EG.5.1 spike protein(6P) in complex with human ACE2
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ |
| Chain | Residue | Details |
| A | THR371-GLN380 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| B | SER689 | |
| C | SER689 | |
| D | SER689 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| B | GLU819 | |
| C | GLU819 | |
| D | GLU819 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| B | ASN20 | |
| B | PRO1162 | |
| B | VAL1177 | |
| C | ASN20 | |
| C | PRO1162 | |
| C | VAL1177 | |
| D | ASN20 | |
| D | PRO1162 | |
| D | VAL1177 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 15 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| B | TRP64 | |
| C | ALA1078 | |
| D | TRP64 | |
| D | ASN125 | |
| D | SER721 | |
| D | ILE805 | |
| D | ALA1078 | |
| B | ASN125 | |
| B | SER721 | |
| B | ILE805 | |
| B | ALA1078 | |
| C | TRP64 | |
| C | ASN125 | |
| C | SER721 | |
| C | ILE805 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| B | LYS77 | |
| B | MET153 | |
| B | ILE1198 | |
| C | LYS77 | |
| C | MET153 | |
| C | ILE1198 | |
| D | LYS77 | |
| D | MET153 | |
| D | ILE1198 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| B | GLU169 | |
| C | LEU335 | |
| C | PHE347 | |
| C | VAL620 | |
| C | GLU661 | |
| C | TRP1102 | |
| D | GLU169 | |
| D | THR286 | |
| D | LEU335 | |
| D | PHE347 | |
| D | VAL620 | |
| B | THR286 | |
| D | GLU661 | |
| D | TRP1102 | |
| B | LEU335 | |
| B | PHE347 | |
| B | VAL620 | |
| B | GLU661 | |
| B | TRP1102 | |
| C | GLU169 | |
| C | THR286 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| B | PHE238 | |
| B | ALA713 | |
| C | PHE238 | |
| C | ALA713 | |
| D | PHE238 | |
| D | ALA713 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| B | VAL327 | |
| C | VAL327 | |
| D | VAL327 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| B | PHE329 | |
| C | PHE329 | |
| D | PHE329 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| B | GLN607 | |
| C | GLN607 | |
| D | GLN607 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583 |
| Chain | Residue | Details |
| B | SER680 | |
| B | GLY682 | |
| C | SER680 | |
| C | GLY682 | |
| D | SER680 | |
| D | GLY682 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| B | TYR1138 | |
| C | TYR1138 | |
| D | TYR1138 |
