Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

8XMQ

Structure of dimeric CD163 in complex with Hb-Hp

Functional Information from GO Data
ChainGOidnamespacecontents
20004252molecular_functionserine-type endopeptidase activity
20005576cellular_componentextracellular region
20006508biological_processproteolysis
20030492molecular_functionhemoglobin binding
C0004601molecular_functionperoxidase activity
C0005344molecular_functionoxygen carrier activity
C0005506molecular_functioniron ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005829cellular_componentcytosol
C0005833cellular_componenthemoglobin complex
C0006954biological_processinflammatory response
C0015670biological_processcarbon dioxide transport
C0015671biological_processoxygen transport
C0016020cellular_componentmembrane
C0019825molecular_functionoxygen binding
C0020037molecular_functionheme binding
C0030185biological_processnitric oxide transport
C0031720molecular_functionhaptoglobin binding
C0031838cellular_componenthaptoglobin-hemoglobin complex
C0042542biological_processresponse to hydrogen peroxide
C0042744biological_processhydrogen peroxide catabolic process
C0046872molecular_functionmetal ion binding
C0048821biological_processerythrocyte development
C0070062cellular_componentextracellular exosome
C0071682cellular_componentendocytic vesicle lumen
C0072562cellular_componentblood microparticle
C0098869biological_processcellular oxidant detoxification
D0005044molecular_functionscavenger receptor activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006953biological_processacute-phase response
D0006954biological_processinflammatory response
D0009897cellular_componentexternal side of plasma membrane
D0016020cellular_componentmembrane
D0016192biological_processvesicle-mediated transport
D0030666cellular_componentendocytic vesicle membrane
D0097110molecular_functionscaffold protein binding
F0005044molecular_functionscavenger receptor activity
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006953biological_processacute-phase response
F0006954biological_processinflammatory response
F0009897cellular_componentexternal side of plasma membrane
F0016020cellular_componentmembrane
F0016192biological_processvesicle-mediated transport
F0030666cellular_componentendocytic vesicle membrane
F0097110molecular_functionscaffold protein binding
G0004601molecular_functionperoxidase activity
G0005344molecular_functionoxygen carrier activity
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005829cellular_componentcytosol
G0005833cellular_componenthemoglobin complex
G0006954biological_processinflammatory response
G0008217biological_processregulation of blood pressure
G0015670biological_processcarbon dioxide transport
G0015671biological_processoxygen transport
G0019825molecular_functionoxygen binding
G0020037molecular_functionheme binding
G0030185biological_processnitric oxide transport
G0030492molecular_functionhemoglobin binding
G0031720molecular_functionhaptoglobin binding
G0031721molecular_functionhemoglobin alpha binding
G0031838cellular_componenthaptoglobin-hemoglobin complex
G0042542biological_processresponse to hydrogen peroxide
G0042744biological_processhydrogen peroxide catabolic process
G0045429biological_processpositive regulation of nitric oxide biosynthetic process
G0046872molecular_functionmetal ion binding
G0048821biological_processerythrocyte development
G0070062cellular_componentextracellular exosome
G0070293biological_processrenal absorption
G0070527biological_processplatelet aggregation
G0071682cellular_componentendocytic vesicle lumen
G0072562cellular_componentblood microparticle
G0097746biological_processblood vessel diameter maintenance
G0098869biological_processcellular oxidant detoxification
G1904724cellular_componenttertiary granule lumen
G1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PROSITE/UniProt
site_idPS00420
Number of Residues38
DetailsSRCR_1 SRCR domain signature. GenkcsGrvEvkvqeeWGtvCnngWsmeavsviCnqlG
ChainResidueDetails
FGLY56-GLY93
FGLY271-GLY308
FGLY724-GLY761
FGLY934-GLY971

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
GVAL1
GHIS2
GLYS82
GHIS143

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: distal binding residue
ChainResidueDetails
GHIS63
FVAL281
FVAL333
FASP360
DVAL269
DVAL281
DVAL333
DASP360

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: proximal binding residue
ChainResidueDetails
GHIS92
CLEU91
CLEU106
CTHR108
CVAL121
CSER133
CALA13
CTYR24
CLEU29
CHIS45
CASP47
CSER52
CVAL55
CGLY59

site_idSWS_FT_FI4
Number of Residues19
DetailsSITE: (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
ChainResidueDetails
GGLU7
GGLY74
GTHR84
GHIS92
GARG104
GLEU110
GGLY119
GPHE122
GALA128
GALA140
GLYS144
GGLY25
GGLY29
GTYR35
GTRP37
GPHE45
GASP52
GGLY56
GPHE71

site_idSWS_FT_FI5
Number of Residues3
DetailsSITE: Not glycated => ECO:0000269|PubMed:7358733
ChainResidueDetails
GLYS59
GLYS82
GLYS95

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: N-pyruvate 2-iminyl-valine; in Hb A1b
ChainResidueDetails
GVAL1
CLYS16
CLYS40

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
GSER9
GSER44

site_idSWS_FT_FI8
Number of Residues3
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
GTHR12
GTHR50
GTHR87

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:4531009
ChainResidueDetails
GLYS59
GLYS82

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411
ChainResidueDetails
GCYS93
CSER124
CSER131
CSER138

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009
ChainResidueDetails
GLYS144
CTHR134
CTHR137

site_idSWS_FT_FI12
Number of Residues1
DetailsCARBOHYD: N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569
ChainResidueDetails
GVAL1
CLYS16
CLYS40

site_idSWS_FT_FI13
Number of Residues4
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
ChainResidueDetails
GLYS8
GLYS17
GLYS66
GLYS120

site_idSWS_FT_FI14
Number of Residues1
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733
ChainResidueDetails
GLYS144

237423

PDB entries from 2025-06-11

PDB statisticsPDBj update infoContact PDBjnumon