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8XM6

Cryo-EM structure of human ZnT1 WT, in the absence of zinc, determined in an outward-facing conformation

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001701biological_processin utero embryonic development
A0005385molecular_functionzinc ion transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006812biological_processmonoatomic cation transport
A0006829biological_processzinc ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006882biological_processintracellular zinc ion homeostasis
A0008324molecular_functionmonoatomic cation transmembrane transporter activity
A0010312biological_processdetoxification of zinc ion
A0015297molecular_functionantiporter activity
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0019855molecular_functioncalcium channel inhibitor activity
A0030315cellular_componentT-tubule
A0030425cellular_componentdendrite
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031965cellular_componentnuclear membrane
A0042742biological_processdefense response to bacterium
A0046872molecular_functionmetal ion binding
A0046929biological_processnegative regulation of neurotransmitter secretion
A0055085biological_processtransmembrane transport
A0061003biological_processpositive regulation of dendritic spine morphogenesis
A0062111biological_processzinc ion import into organelle
A0070509biological_processcalcium ion import
A0070574biological_processcadmium ion transmembrane transport
A0071577biological_processzinc ion transmembrane transport
A0071584biological_processnegative regulation of zinc ion transmembrane import
A0071585biological_processdetoxification of cadmium ion
A0090281biological_processnegative regulation of calcium ion import
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098839cellular_componentpostsynaptic density membrane
A0099092cellular_componentpostsynaptic density, intracellular component
A0099573cellular_componentglutamatergic postsynaptic density
A0140826molecular_functionzinc:proton antiporter activity
A0140882biological_processzinc export across plasma membrane
A1902897biological_processregulation of postsynaptic density protein 95 clustering
B0000139cellular_componentGolgi membrane
B0001701biological_processin utero embryonic development
B0005385molecular_functionzinc ion transmembrane transporter activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006812biological_processmonoatomic cation transport
B0006829biological_processzinc ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006882biological_processintracellular zinc ion homeostasis
B0008324molecular_functionmonoatomic cation transmembrane transporter activity
B0010312biological_processdetoxification of zinc ion
B0015297molecular_functionantiporter activity
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0019855molecular_functioncalcium channel inhibitor activity
B0030315cellular_componentT-tubule
B0030425cellular_componentdendrite
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0031965cellular_componentnuclear membrane
B0042742biological_processdefense response to bacterium
B0046872molecular_functionmetal ion binding
B0046929biological_processnegative regulation of neurotransmitter secretion
B0055085biological_processtransmembrane transport
B0061003biological_processpositive regulation of dendritic spine morphogenesis
B0062111biological_processzinc ion import into organelle
B0070509biological_processcalcium ion import
B0070574biological_processcadmium ion transmembrane transport
B0071577biological_processzinc ion transmembrane transport
B0071584biological_processnegative regulation of zinc ion transmembrane import
B0071585biological_processdetoxification of cadmium ion
B0090281biological_processnegative regulation of calcium ion import
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098839cellular_componentpostsynaptic density membrane
B0099092cellular_componentpostsynaptic density, intracellular component
B0099573cellular_componentglutamatergic postsynaptic density
B0140826molecular_functionzinc:proton antiporter activity
B0140882biological_processzinc export across plasma membrane
B1902897biological_processregulation of postsynaptic density protein 95 clustering
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues240
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues32
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"31471319","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues42
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"31471319","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q62720","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P69380","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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