8XL4

Structure of human propionyl-CoA carboxylase in complex with acetyl-CoA (PCC-ACO)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004658	molecular_function	propionyl-CoA carboxylase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0009081	biological_process	branched-chain amino acid metabolic process
A	0009374	molecular_function	biotin binding
A	0016042	biological_process	lipid catabolic process
A	0016874	molecular_function	ligase activity
A	0016885	molecular_function	ligase activity, forming carbon-carbon bonds
A	0019626	biological_process	short-chain fatty acid catabolic process
A	0019899	molecular_function	enzyme binding
A	0046872	molecular_function	metal ion binding
A	1901290	biological_process	succinyl-CoA biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0004658	molecular_function	propionyl-CoA carboxylase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006631	biological_process	fatty acid metabolic process
B	0009062	biological_process	fatty acid catabolic process
B	0009081	biological_process	branched-chain amino acid metabolic process
B	0016874	molecular_function	ligase activity
B	0019626	biological_process	short-chain fatty acid catabolic process
C	0000166	molecular_function	nucleotide binding
C	0004658	molecular_function	propionyl-CoA carboxylase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0009081	biological_process	branched-chain amino acid metabolic process
C	0009374	molecular_function	biotin binding
C	0016042	biological_process	lipid catabolic process
C	0016874	molecular_function	ligase activity
C	0016885	molecular_function	ligase activity, forming carbon-carbon bonds
C	0019626	biological_process	short-chain fatty acid catabolic process
C	0019899	molecular_function	enzyme binding
C	0046872	molecular_function	metal ion binding
C	1901290	biological_process	succinyl-CoA biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0004658	molecular_function	propionyl-CoA carboxylase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005829	cellular_component	cytosol
D	0006631	biological_process	fatty acid metabolic process
D	0009062	biological_process	fatty acid catabolic process
D	0009081	biological_process	branched-chain amino acid metabolic process
D	0016874	molecular_function	ligase activity
D	0019626	biological_process	short-chain fatty acid catabolic process
E	0000166	molecular_function	nucleotide binding
E	0004658	molecular_function	propionyl-CoA carboxylase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005829	cellular_component	cytosol
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0009081	biological_process	branched-chain amino acid metabolic process
E	0009374	molecular_function	biotin binding
E	0016042	biological_process	lipid catabolic process
E	0016874	molecular_function	ligase activity
E	0016885	molecular_function	ligase activity, forming carbon-carbon bonds
E	0019626	biological_process	short-chain fatty acid catabolic process
E	0019899	molecular_function	enzyme binding
E	0046872	molecular_function	metal ion binding
E	1901290	biological_process	succinyl-CoA biosynthetic process
F	0000166	molecular_function	nucleotide binding
F	0004658	molecular_function	propionyl-CoA carboxylase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005829	cellular_component	cytosol
F	0006631	biological_process	fatty acid metabolic process
F	0009062	biological_process	fatty acid catabolic process
F	0009081	biological_process	branched-chain amino acid metabolic process
F	0016874	molecular_function	ligase activity
F	0019626	biological_process	short-chain fatty acid catabolic process
G	0000166	molecular_function	nucleotide binding
G	0004658	molecular_function	propionyl-CoA carboxylase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005829	cellular_component	cytosol
G	0006629	biological_process	lipid metabolic process
G	0006631	biological_process	fatty acid metabolic process
G	0009081	biological_process	branched-chain amino acid metabolic process
G	0009374	molecular_function	biotin binding
G	0016042	biological_process	lipid catabolic process
G	0016874	molecular_function	ligase activity
G	0016885	molecular_function	ligase activity, forming carbon-carbon bonds
G	0019626	biological_process	short-chain fatty acid catabolic process
G	0019899	molecular_function	enzyme binding
G	0046872	molecular_function	metal ion binding
G	1901290	biological_process	succinyl-CoA biosynthetic process
H	0000166	molecular_function	nucleotide binding
H	0004658	molecular_function	propionyl-CoA carboxylase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005829	cellular_component	cytosol
H	0006631	biological_process	fatty acid metabolic process
H	0009062	biological_process	fatty acid catabolic process
H	0009081	biological_process	branched-chain amino acid metabolic process
H	0016874	molecular_function	ligase activity
H	0019626	biological_process	short-chain fatty acid catabolic process
I	0000166	molecular_function	nucleotide binding
I	0004658	molecular_function	propionyl-CoA carboxylase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0005829	cellular_component	cytosol
I	0006629	biological_process	lipid metabolic process
I	0006631	biological_process	fatty acid metabolic process
I	0009081	biological_process	branched-chain amino acid metabolic process
I	0009374	molecular_function	biotin binding
I	0016042	biological_process	lipid catabolic process
I	0016874	molecular_function	ligase activity
I	0016885	molecular_function	ligase activity, forming carbon-carbon bonds
I	0019626	biological_process	short-chain fatty acid catabolic process
I	0019899	molecular_function	enzyme binding
I	0046872	molecular_function	metal ion binding
I	1901290	biological_process	succinyl-CoA biosynthetic process
J	0000166	molecular_function	nucleotide binding
J	0004658	molecular_function	propionyl-CoA carboxylase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0005829	cellular_component	cytosol
J	0006631	biological_process	fatty acid metabolic process
J	0009062	biological_process	fatty acid catabolic process
J	0009081	biological_process	branched-chain amino acid metabolic process
J	0016874	molecular_function	ligase activity
J	0019626	biological_process	short-chain fatty acid catabolic process
K	0000166	molecular_function	nucleotide binding
K	0004658	molecular_function	propionyl-CoA carboxylase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0005829	cellular_component	cytosol
K	0006629	biological_process	lipid metabolic process
K	0006631	biological_process	fatty acid metabolic process
K	0009081	biological_process	branched-chain amino acid metabolic process
K	0009374	molecular_function	biotin binding
K	0016042	biological_process	lipid catabolic process
K	0016874	molecular_function	ligase activity
K	0016885	molecular_function	ligase activity, forming carbon-carbon bonds
K	0019626	biological_process	short-chain fatty acid catabolic process
K	0019899	molecular_function	enzyme binding
K	0046872	molecular_function	metal ion binding
K	1901290	biological_process	succinyl-CoA biosynthetic process
L	0000166	molecular_function	nucleotide binding
L	0004658	molecular_function	propionyl-CoA carboxylase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0005829	cellular_component	cytosol
L	0006631	biological_process	fatty acid metabolic process
L	0009062	biological_process	fatty acid catabolic process
L	0009081	biological_process	branched-chain amino acid metabolic process
L	0016874	molecular_function	ligase activity
L	0019626	biological_process	short-chain fatty acid catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00188
Number of Residues	18
Details	BIOTIN Biotin-requiring enzymes attachment site. GQeIcvIeAMKMqnsMtA

Chain	Residue	Details
A	GLY684-ALA701

---

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. YPVMIKASaggGGkG

Chain	Residue	Details
A	TYR214-GLY228

---

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. FLEMNTRL

Chain	Residue	Details
A	PHE347-LEU354

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2235
Details	Domain: {"description":"Biotin carboxylation","evidences":[{"source":"PROSITE-ProRule","id":"PRU00969","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	985
Details	Domain: {"description":"ATP-grasp","evidences":[{"source":"PROSITE-ProRule","id":"PRU00409","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	375
Details	Domain: {"description":"Biotinyl-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU01066","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	15
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	320
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00409","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q5LUF3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q91ZA3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	36
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q91ZA3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q91ZA3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	5
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q91ZA3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	5
Details	Modified residue: {"description":"N6-biotinyllysine; by HLCS","evidences":[{"source":"PROSITE-ProRule","id":"PRU01066","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20443544","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1434
Details	Domain: {"description":"CoA carboxyltransferase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01137","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	198
Details	Region: {"description":"Acyl-CoA binding","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	18
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q99MN9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	6
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q99MN9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---