Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

8XJI

Structure of chimeric RyR complex with flubendiamide

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003151biological_processoutflow tract morphogenesis
A0005216molecular_functionmonoatomic ion channel activity
A0005219molecular_functionryanodine-sensitive calcium-release channel activity
A0005245molecular_functionvoltage-gated calcium channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005790cellular_componentsmooth endoplasmic reticulum
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006936biological_processmuscle contraction
A0006941biological_processstriated muscle contraction
A0008144molecular_functionobsolete drug binding
A0014802cellular_componentterminal cisterna
A0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0015278molecular_functionintracellularly gated calcium channel activity
A0015643molecular_functiontoxic substance binding
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0030018cellular_componentZ disc
A0031090cellular_componentorganelle membrane
A0033017cellular_componentsarcoplasmic reticulum membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034704cellular_componentcalcium channel complex
A0035381molecular_functionATP-gated ion channel activity
A0042383cellular_componentsarcolemma
A0042802molecular_functionidentical protein binding
A0043588biological_processskin development
A0043931biological_processossification involved in bone maturation
A0044325molecular_functiontransmembrane transporter binding
A0046872molecular_functionmetal ion binding
A0048741biological_processskeletal muscle fiber development
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0071277biological_processcellular response to calcium ion
A0071313biological_processcellular response to caffeine
A0097718molecular_functiondisordered domain specific binding
A1990425cellular_componentryanodine receptor complex
B0000166molecular_functionnucleotide binding
B0003151biological_processoutflow tract morphogenesis
B0005216molecular_functionmonoatomic ion channel activity
B0005219molecular_functionryanodine-sensitive calcium-release channel activity
B0005245molecular_functionvoltage-gated calcium channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005790cellular_componentsmooth endoplasmic reticulum
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006936biological_processmuscle contraction
B0006941biological_processstriated muscle contraction
B0008144molecular_functionobsolete drug binding
B0014802cellular_componentterminal cisterna
B0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0015278molecular_functionintracellularly gated calcium channel activity
B0015643molecular_functiontoxic substance binding
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0019722biological_processcalcium-mediated signaling
B0030018cellular_componentZ disc
B0031090cellular_componentorganelle membrane
B0033017cellular_componentsarcoplasmic reticulum membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034704cellular_componentcalcium channel complex
B0035381molecular_functionATP-gated ion channel activity
B0042383cellular_componentsarcolemma
B0042802molecular_functionidentical protein binding
B0043588biological_processskin development
B0043931biological_processossification involved in bone maturation
B0044325molecular_functiontransmembrane transporter binding
B0046872molecular_functionmetal ion binding
B0048741biological_processskeletal muscle fiber development
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0071277biological_processcellular response to calcium ion
B0071313biological_processcellular response to caffeine
B0097718molecular_functiondisordered domain specific binding
B1990425cellular_componentryanodine receptor complex
C0000166molecular_functionnucleotide binding
C0003151biological_processoutflow tract morphogenesis
C0005216molecular_functionmonoatomic ion channel activity
C0005219molecular_functionryanodine-sensitive calcium-release channel activity
C0005245molecular_functionvoltage-gated calcium channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005790cellular_componentsmooth endoplasmic reticulum
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0006936biological_processmuscle contraction
C0006941biological_processstriated muscle contraction
C0008144molecular_functionobsolete drug binding
C0014802cellular_componentterminal cisterna
C0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0015278molecular_functionintracellularly gated calcium channel activity
C0015643molecular_functiontoxic substance binding
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0030018cellular_componentZ disc
C0031090cellular_componentorganelle membrane
C0033017cellular_componentsarcoplasmic reticulum membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034704cellular_componentcalcium channel complex
C0035381molecular_functionATP-gated ion channel activity
C0042383cellular_componentsarcolemma
C0042802molecular_functionidentical protein binding
C0043588biological_processskin development
C0043931biological_processossification involved in bone maturation
C0044325molecular_functiontransmembrane transporter binding
C0046872molecular_functionmetal ion binding
C0048741biological_processskeletal muscle fiber development
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0071277biological_processcellular response to calcium ion
C0071313biological_processcellular response to caffeine
C0097718molecular_functiondisordered domain specific binding
C1990425cellular_componentryanodine receptor complex
D0000166molecular_functionnucleotide binding
D0003151biological_processoutflow tract morphogenesis
D0005216molecular_functionmonoatomic ion channel activity
D0005219molecular_functionryanodine-sensitive calcium-release channel activity
D0005245molecular_functionvoltage-gated calcium channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005790cellular_componentsmooth endoplasmic reticulum
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0006936biological_processmuscle contraction
D0006941biological_processstriated muscle contraction
D0008144molecular_functionobsolete drug binding
D0014802cellular_componentterminal cisterna
D0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0015278molecular_functionintracellularly gated calcium channel activity
D0015643molecular_functiontoxic substance binding
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0019722biological_processcalcium-mediated signaling
D0030018cellular_componentZ disc
D0031090cellular_componentorganelle membrane
D0033017cellular_componentsarcoplasmic reticulum membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034704cellular_componentcalcium channel complex
D0035381molecular_functionATP-gated ion channel activity
D0042383cellular_componentsarcolemma
D0042802molecular_functionidentical protein binding
D0043588biological_processskin development
D0043931biological_processossification involved in bone maturation
D0044325molecular_functiontransmembrane transporter binding
D0046872molecular_functionmetal ion binding
D0048741biological_processskeletal muscle fiber development
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0071277biological_processcellular response to calcium ion
D0071313biological_processcellular response to caffeine
D0097718molecular_functiondisordered domain specific binding
D1990425cellular_componentryanodine receptor complex
E0002027biological_processregulation of heart rate
E0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
E0005102molecular_functionsignaling receptor binding
E0005246molecular_functioncalcium channel regulator activity
E0005515molecular_functionprotein binding
E0005528molecular_functionFK506 binding
E0005737cellular_componentcytoplasm
E0006458biological_process'de novo' protein folding
E0006939biological_processsmooth muscle contraction
E0007204biological_processpositive regulation of cytosolic calcium ion concentration
E0009749biological_processresponse to glucose
E0010459biological_processnegative regulation of heart rate
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0016020cellular_componentmembrane
E0016529cellular_componentsarcoplasmic reticulum
E0016853molecular_functionisomerase activity
E0019227biological_processneuronal action potential propagation
E0019722biological_processcalcium-mediated signaling
E0019855molecular_functioncalcium channel inhibitor activity
E0030018cellular_componentZ disc
E0030073biological_processinsulin secretion
E0033017cellular_componentsarcoplasmic reticulum membrane
E0034704cellular_componentcalcium channel complex
E0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
E0042026biological_processprotein refolding
E0042098biological_processT cell proliferation
E0044325molecular_functiontransmembrane transporter binding
E0050849biological_processnegative regulation of calcium-mediated signaling
E0051209biological_processrelease of sequestered calcium ion into cytosol
E0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
E0051284biological_processpositive regulation of sequestering of calcium ion
E0051604biological_processprotein maturation
E0051775biological_processresponse to redox state
E0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
F0002027biological_processregulation of heart rate
F0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
F0005102molecular_functionsignaling receptor binding
F0005246molecular_functioncalcium channel regulator activity
F0005515molecular_functionprotein binding
F0005528molecular_functionFK506 binding
F0005737cellular_componentcytoplasm
F0006458biological_process'de novo' protein folding
F0006939biological_processsmooth muscle contraction
F0007204biological_processpositive regulation of cytosolic calcium ion concentration
F0009749biological_processresponse to glucose
F0010459biological_processnegative regulation of heart rate
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016020cellular_componentmembrane
F0016529cellular_componentsarcoplasmic reticulum
F0016853molecular_functionisomerase activity
F0019227biological_processneuronal action potential propagation
F0019722biological_processcalcium-mediated signaling
F0019855molecular_functioncalcium channel inhibitor activity
F0030018cellular_componentZ disc
F0030073biological_processinsulin secretion
F0033017cellular_componentsarcoplasmic reticulum membrane
F0034704cellular_componentcalcium channel complex
F0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
F0042026biological_processprotein refolding
F0042098biological_processT cell proliferation
F0044325molecular_functiontransmembrane transporter binding
F0050849biological_processnegative regulation of calcium-mediated signaling
F0051209biological_processrelease of sequestered calcium ion into cytosol
F0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
F0051284biological_processpositive regulation of sequestering of calcium ion
F0051604biological_processprotein maturation
F0051775biological_processresponse to redox state
F0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
G0002027biological_processregulation of heart rate
G0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
G0005102molecular_functionsignaling receptor binding
G0005246molecular_functioncalcium channel regulator activity
G0005515molecular_functionprotein binding
G0005528molecular_functionFK506 binding
G0005737cellular_componentcytoplasm
G0006458biological_process'de novo' protein folding
G0006939biological_processsmooth muscle contraction
G0007204biological_processpositive regulation of cytosolic calcium ion concentration
G0009749biological_processresponse to glucose
G0010459biological_processnegative regulation of heart rate
G0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G0016020cellular_componentmembrane
G0016529cellular_componentsarcoplasmic reticulum
G0016853molecular_functionisomerase activity
G0019227biological_processneuronal action potential propagation
G0019722biological_processcalcium-mediated signaling
G0019855molecular_functioncalcium channel inhibitor activity
G0030018cellular_componentZ disc
G0030073biological_processinsulin secretion
G0033017cellular_componentsarcoplasmic reticulum membrane
G0034704cellular_componentcalcium channel complex
G0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
G0042026biological_processprotein refolding
G0042098biological_processT cell proliferation
G0044325molecular_functiontransmembrane transporter binding
G0050849biological_processnegative regulation of calcium-mediated signaling
G0051209biological_processrelease of sequestered calcium ion into cytosol
G0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
G0051284biological_processpositive regulation of sequestering of calcium ion
G0051604biological_processprotein maturation
G0051775biological_processresponse to redox state
G0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
H0002027biological_processregulation of heart rate
H0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
H0005102molecular_functionsignaling receptor binding
H0005246molecular_functioncalcium channel regulator activity
H0005515molecular_functionprotein binding
H0005528molecular_functionFK506 binding
H0005737cellular_componentcytoplasm
H0006458biological_process'de novo' protein folding
H0006939biological_processsmooth muscle contraction
H0007204biological_processpositive regulation of cytosolic calcium ion concentration
H0009749biological_processresponse to glucose
H0010459biological_processnegative regulation of heart rate
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H0016020cellular_componentmembrane
H0016529cellular_componentsarcoplasmic reticulum
H0016853molecular_functionisomerase activity
H0019227biological_processneuronal action potential propagation
H0019722biological_processcalcium-mediated signaling
H0019855molecular_functioncalcium channel inhibitor activity
H0030018cellular_componentZ disc
H0030073biological_processinsulin secretion
H0033017cellular_componentsarcoplasmic reticulum membrane
H0034704cellular_componentcalcium channel complex
H0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
H0042026biological_processprotein refolding
H0042098biological_processT cell proliferation
H0044325molecular_functiontransmembrane transporter binding
H0050849biological_processnegative regulation of calcium-mediated signaling
H0051209biological_processrelease of sequestered calcium ion into cytosol
H0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
H0051284biological_processpositive regulation of sequestering of calcium ion
H0051604biological_processprotein maturation
H0051775biological_processresponse to redox state
H0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
I0000086biological_processG2/M transition of mitotic cell cycle
I0000922cellular_componentspindle pole
I0002027biological_processregulation of heart rate
I0005246molecular_functioncalcium channel regulator activity
I0005509molecular_functioncalcium ion binding
I0005513biological_processdetection of calcium ion
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005813cellular_componentcentrosome
I0005819cellular_componentspindle
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005876cellular_componentspindle microtubule
I0005886cellular_componentplasma membrane
I0005929cellular_componentcilium
I0007186biological_processG protein-coupled receptor signaling pathway
I0007259biological_processcell surface receptor signaling pathway via JAK-STAT
I0008076cellular_componentvoltage-gated potassium channel complex
I0010856molecular_functionadenylate cyclase activator activity
I0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
I0016020cellular_componentmembrane
I0016240biological_processautophagosome membrane docking
I0019855molecular_functioncalcium channel inhibitor activity
I0019901molecular_functionprotein kinase binding
I0021762biological_processsubstantia nigra development
I0030017cellular_componentsarcomere
I0030672cellular_componentsynaptic vesicle membrane
I0031432molecular_functiontitin binding
I0031514cellular_componentmotile cilium
I0031982cellular_componentvesicle
I0032465biological_processregulation of cytokinesis
I0032991cellular_componentprotein-containing complex
I0034704cellular_componentcalcium channel complex
I0035458biological_processcellular response to interferon-beta
I0042995cellular_componentcell projection
I0043209cellular_componentmyelin sheath
I0043539molecular_functionprotein serine/threonine kinase activator activity
I0044305cellular_componentcalyx of Held
I0044325molecular_functiontransmembrane transporter binding
I0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
I0046872molecular_functionmetal ion binding
I0048306molecular_functioncalcium-dependent protein binding
I0050848biological_processregulation of calcium-mediated signaling
I0051592biological_processresponse to calcium ion
I0055117biological_processregulation of cardiac muscle contraction
I0060291biological_processlong-term synaptic potentiation
I0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
I0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
I0071346biological_processcellular response to type II interferon
I0072542molecular_functionprotein phosphatase activator activity
I0097225cellular_componentsperm midpiece
I0097720biological_processcalcineurin-mediated signaling
I0098901biological_processregulation of cardiac muscle cell action potential
I0099523cellular_componentpresynaptic cytosol
I0140056biological_processorganelle localization by membrane tethering
I0140238biological_processpresynaptic endocytosis
I0141110molecular_functiontransporter inhibitor activity
I1901842biological_processnegative regulation of high voltage-gated calcium channel activity
I1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
I1902494cellular_componentcatalytic complex
I1905913biological_processnegative regulation of calcium ion export across plasma membrane
I1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
J0000086biological_processG2/M transition of mitotic cell cycle
J0000922cellular_componentspindle pole
J0002027biological_processregulation of heart rate
J0005246molecular_functioncalcium channel regulator activity
J0005509molecular_functioncalcium ion binding
J0005513biological_processdetection of calcium ion
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005813cellular_componentcentrosome
J0005819cellular_componentspindle
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0005876cellular_componentspindle microtubule
J0005886cellular_componentplasma membrane
J0005929cellular_componentcilium
J0007186biological_processG protein-coupled receptor signaling pathway
J0007259biological_processcell surface receptor signaling pathway via JAK-STAT
J0008076cellular_componentvoltage-gated potassium channel complex
J0010856molecular_functionadenylate cyclase activator activity
J0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
J0016020cellular_componentmembrane
J0016240biological_processautophagosome membrane docking
J0019855molecular_functioncalcium channel inhibitor activity
J0019901molecular_functionprotein kinase binding
J0021762biological_processsubstantia nigra development
J0030017cellular_componentsarcomere
J0030672cellular_componentsynaptic vesicle membrane
J0031432molecular_functiontitin binding
J0031514cellular_componentmotile cilium
J0031982cellular_componentvesicle
J0032465biological_processregulation of cytokinesis
J0032991cellular_componentprotein-containing complex
J0034704cellular_componentcalcium channel complex
J0035458biological_processcellular response to interferon-beta
J0042995cellular_componentcell projection
J0043209cellular_componentmyelin sheath
J0043539molecular_functionprotein serine/threonine kinase activator activity
J0044305cellular_componentcalyx of Held
J0044325molecular_functiontransmembrane transporter binding
J0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
J0046872molecular_functionmetal ion binding
J0048306molecular_functioncalcium-dependent protein binding
J0050848biological_processregulation of calcium-mediated signaling
J0051592biological_processresponse to calcium ion
J0055117biological_processregulation of cardiac muscle contraction
J0060291biological_processlong-term synaptic potentiation
J0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
J0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
J0071346biological_processcellular response to type II interferon
J0072542molecular_functionprotein phosphatase activator activity
J0097225cellular_componentsperm midpiece
J0097720biological_processcalcineurin-mediated signaling
J0098901biological_processregulation of cardiac muscle cell action potential
J0099523cellular_componentpresynaptic cytosol
J0140056biological_processorganelle localization by membrane tethering
J0140238biological_processpresynaptic endocytosis
J0141110molecular_functiontransporter inhibitor activity
J1901842biological_processnegative regulation of high voltage-gated calcium channel activity
J1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
J1902494cellular_componentcatalytic complex
J1905913biological_processnegative regulation of calcium ion export across plasma membrane
J1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
K0000086biological_processG2/M transition of mitotic cell cycle
K0000922cellular_componentspindle pole
K0002027biological_processregulation of heart rate
K0005246molecular_functioncalcium channel regulator activity
K0005509molecular_functioncalcium ion binding
K0005513biological_processdetection of calcium ion
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0005813cellular_componentcentrosome
K0005819cellular_componentspindle
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0005876cellular_componentspindle microtubule
K0005886cellular_componentplasma membrane
K0005929cellular_componentcilium
K0007186biological_processG protein-coupled receptor signaling pathway
K0007259biological_processcell surface receptor signaling pathway via JAK-STAT
K0008076cellular_componentvoltage-gated potassium channel complex
K0010856molecular_functionadenylate cyclase activator activity
K0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
K0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
K0016020cellular_componentmembrane
K0016240biological_processautophagosome membrane docking
K0019855molecular_functioncalcium channel inhibitor activity
K0019901molecular_functionprotein kinase binding
K0021762biological_processsubstantia nigra development
K0030017cellular_componentsarcomere
K0030672cellular_componentsynaptic vesicle membrane
K0031432molecular_functiontitin binding
K0031514cellular_componentmotile cilium
K0031982cellular_componentvesicle
K0032465biological_processregulation of cytokinesis
K0032991cellular_componentprotein-containing complex
K0034704cellular_componentcalcium channel complex
K0035458biological_processcellular response to interferon-beta
K0042995cellular_componentcell projection
K0043209cellular_componentmyelin sheath
K0043539molecular_functionprotein serine/threonine kinase activator activity
K0044305cellular_componentcalyx of Held
K0044325molecular_functiontransmembrane transporter binding
K0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
K0046872molecular_functionmetal ion binding
K0048306molecular_functioncalcium-dependent protein binding
K0050848biological_processregulation of calcium-mediated signaling
K0051592biological_processresponse to calcium ion
K0055117biological_processregulation of cardiac muscle contraction
K0060291biological_processlong-term synaptic potentiation
K0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
K0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
K0071346biological_processcellular response to type II interferon
K0072542molecular_functionprotein phosphatase activator activity
K0097225cellular_componentsperm midpiece
K0097720biological_processcalcineurin-mediated signaling
K0098901biological_processregulation of cardiac muscle cell action potential
K0099523cellular_componentpresynaptic cytosol
K0140056biological_processorganelle localization by membrane tethering
K0140238biological_processpresynaptic endocytosis
K0141110molecular_functiontransporter inhibitor activity
K1901842biological_processnegative regulation of high voltage-gated calcium channel activity
K1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
K1902494cellular_componentcatalytic complex
K1905913biological_processnegative regulation of calcium ion export across plasma membrane
K1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
L0000086biological_processG2/M transition of mitotic cell cycle
L0000922cellular_componentspindle pole
L0002027biological_processregulation of heart rate
L0005246molecular_functioncalcium channel regulator activity
L0005509molecular_functioncalcium ion binding
L0005513biological_processdetection of calcium ion
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005737cellular_componentcytoplasm
L0005813cellular_componentcentrosome
L0005819cellular_componentspindle
L0005829cellular_componentcytosol
L0005856cellular_componentcytoskeleton
L0005876cellular_componentspindle microtubule
L0005886cellular_componentplasma membrane
L0005929cellular_componentcilium
L0007186biological_processG protein-coupled receptor signaling pathway
L0007259biological_processcell surface receptor signaling pathway via JAK-STAT
L0008076cellular_componentvoltage-gated potassium channel complex
L0010856molecular_functionadenylate cyclase activator activity
L0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
L0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
L0016020cellular_componentmembrane
L0016240biological_processautophagosome membrane docking
L0019855molecular_functioncalcium channel inhibitor activity
L0019901molecular_functionprotein kinase binding
L0021762biological_processsubstantia nigra development
L0030017cellular_componentsarcomere
L0030672cellular_componentsynaptic vesicle membrane
L0031432molecular_functiontitin binding
L0031514cellular_componentmotile cilium
L0031982cellular_componentvesicle
L0032465biological_processregulation of cytokinesis
L0032991cellular_componentprotein-containing complex
L0034704cellular_componentcalcium channel complex
L0035458biological_processcellular response to interferon-beta
L0042995cellular_componentcell projection
L0043209cellular_componentmyelin sheath
L0043539molecular_functionprotein serine/threonine kinase activator activity
L0044305cellular_componentcalyx of Held
L0044325molecular_functiontransmembrane transporter binding
L0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
L0046872molecular_functionmetal ion binding
L0048306molecular_functioncalcium-dependent protein binding
L0050848biological_processregulation of calcium-mediated signaling
L0051592biological_processresponse to calcium ion
L0055117biological_processregulation of cardiac muscle contraction
L0060291biological_processlong-term synaptic potentiation
L0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
L0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
L0071346biological_processcellular response to type II interferon
L0072542molecular_functionprotein phosphatase activator activity
L0097225cellular_componentsperm midpiece
L0097720biological_processcalcineurin-mediated signaling
L0098901biological_processregulation of cardiac muscle cell action potential
L0099523cellular_componentpresynaptic cytosol
L0140056biological_processorganelle localization by membrane tethering
L0140238biological_processpresynaptic endocytosis
L0141110molecular_functiontransporter inhibitor activity
L1901842biological_processnegative regulation of high voltage-gated calcium channel activity
L1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
L1902494cellular_componentcatalytic complex
L1905913biological_processnegative regulation of calcium ion export across plasma membrane
L1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues19136
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
DMET1-ASN4558
BASN4662-LYS4779
BLYS4821-LYS4835
BGLY4941-SER5037
CMET1-ASN4558
CASN4662-LYS4779
CLYS4821-LYS4835
CGLY4941-SER5037
KASP59
KASN61
KTHR63
DASN4662-LYS4779
KALA68
JASP21
JASP23
JASP25
JTHR27
JALA32
JASP57
JASP59
JASN61
JTHR63
DLYS4821-LYS4835
JALA68
IASP21
IASP23
IASP25
ITHR27
IALA32
IASP57
IASP59
IASN61
ITHR63
DGLY4941-SER5037
IALA68
AMET1-ASN4558
AASN4662-LYS4779
ALYS4821-LYS4835
AGLY4941-SER5037
BMET1-ASN4558

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
DPHE4559-PHE4579
KALA105
JASP94
JASP96
JASN98
JTYR100
JALA105
IASP94
IASP96
IASN98
ITYR100
APHE4559-PHE4579
IALA105
BPHE4559-PHE4579
CPHE4559-PHE4579
LALA105
KASP94
KASP96
KASN98
KTYR100

site_idSWS_FT_FI3
Number of Residues408
DetailsTOPO_DOM: Lumenal => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
DTYR4580-GLU4640
BHIS4803
BASN4857-MET4879
BGLU4900-THR4919
CTYR4580-GLU4640
CHIS4803
CASN4857-MET4879
CGLU4900-THR4919
IASP132
IASP134
IGLN136
DHIS4803
IALA141
DASN4857-MET4879
DGLU4900-THR4919
ATYR4580-GLU4640
AHIS4803
AASN4857-MET4879
AGLU4900-THR4919
BTYR4580-GLU4640

site_idSWS_FT_FI4
Number of Residues80
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
DPRO4641-TYR4661
APRO4641-TYR4661
BPRO4641-TYR4661
CPRO4641-TYR4661

site_idSWS_FT_FI5
Number of Residues88
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
DPHE4780-GLY4802
APHE4780-GLY4802
BPHE4780-GLY4802
CPHE4780-GLY4802

site_idSWS_FT_FI6
Number of Residues64
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
DTYR4804-VAL4820
ATYR4804-VAL4820
BTYR4804-VAL4820
CTYR4804-VAL4820

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
DGLN4836-PHE4856
AGLN4836-PHE4856
BGLN4836-PHE4856
CGLN4836-PHE4856

site_idSWS_FT_FI8
Number of Residues76
DetailsINTRAMEM: Pore-forming => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
DMET4880-ASP4899
AMET4880-ASP4899
BMET4880-ASP4899
CMET4880-ASP4899

site_idSWS_FT_FI9
Number of Residues80
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
DPHE4920-PHE4940
APHE4920-PHE4940
BPHE4920-PHE4940
CPHE4920-PHE4940

site_idSWS_FT_FI10
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5TA3, ECO:0007744|PDB:5TAL, ECO:0007744|PDB:5TAM, ECO:0007744|PDB:5TAN
ChainResidueDetails
DGLU3893
CGLU3893
CGLU3967
CTHR5001
DGLU3967
DTHR5001
AGLU3893
AGLU3967
ATHR5001
BGLU3893
BGLU3967
BTHR5001

site_idSWS_FT_FI11
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5T9V, ECO:0007744|PDB:5TA3, ECO:0007744|PDB:5TAL, ECO:0007744|PDB:5TAM, ECO:0007744|PDB:5TAN, ECO:0007744|PDB:5TAS, ECO:0007744|PDB:5TAT, ECO:0007744|PDB:5TAU
ChainResidueDetails
DLYS4211
CLYS4211
CMET4954
CTHR4979
DMET4954
DTHR4979
ALYS4211
AMET4954
ATHR4979
BLYS4211
BMET4954
BTHR4979

site_idSWS_FT_FI12
Number of Residues4
DetailsBINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5TAN
ChainResidueDetails
DTRP4716
ATRP4716
BTRP4716
CTRP4716

site_idSWS_FT_FI13
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:F1LMY4
ChainResidueDetails
DSER1338
CSER1338
CSER2345
CSER4470
DSER2345
DSER4470
ASER1338
ASER2345
ASER4470
BSER1338
BSER2345
BSER4470

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA and PKG => ECO:0000269|PubMed:8380342
ChainResidueDetails
DSER2843
ASER2843
BSER2843
CSER2843
JLYS22
ILYS22

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:10601232, ECO:0000269|PubMed:11562475, ECO:0000269|PubMed:22036948
ChainResidueDetails
DCYS3635
ACYS3635
BCYS3635
CCYS3635

site_idSWS_FT_FI16
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:F1LMY4
ChainResidueDetails
DTHR4466
ATHR4466
BTHR4466
CTHR4466

site_idSWS_FT_FI17
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P21817
ChainResidueDetails
DTYR4863
ATYR4863
BTYR4863
CTYR4863

site_idSWS_FT_FI18
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P21817
ChainResidueDetails
DSER4866
ASER4866
BSER4866
CSER4866

237423

PDB entries from 2025-06-11

PDB statisticsPDBj update infoContact PDBjnumon