8XHU

Crystal structure of Helicobacter pylori IspDF

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0008299	biological_process	isoprenoid biosynthetic process
A	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A	0016114	biological_process	terpenoid biosynthetic process
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016829	molecular_function	lyase activity
A	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
A	0046872	molecular_function	metal ion binding
A	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A	0070567	molecular_function	cytidylyltransferase activity
B	0003824	molecular_function	catalytic activity
B	0008299	biological_process	isoprenoid biosynthetic process
B	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B	0016114	biological_process	terpenoid biosynthetic process
B	0016779	molecular_function	nucleotidyltransferase activity
B	0016829	molecular_function	lyase activity
B	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
B	0046872	molecular_function	metal ion binding
B	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B	0070567	molecular_function	cytidylyltransferase activity
C	0003824	molecular_function	catalytic activity
C	0008299	biological_process	isoprenoid biosynthetic process
C	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C	0016114	biological_process	terpenoid biosynthetic process
C	0016779	molecular_function	nucleotidyltransferase activity
C	0016829	molecular_function	lyase activity
C	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
C	0046872	molecular_function	metal ion binding
C	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C	0070567	molecular_function	cytidylyltransferase activity

Functional Information from PROSITE/UniProt

site_id	PS01295
Number of Residues	8
Details	ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. TLTSDVAR

Chain	Residue	Details
A	THR126-ARG133

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site_id	PS01350
Number of Residues	16
Details	ISPF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. SDGDALlHAviDAilG

Chain	Residue	Details
A	SER281-GLY296

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	27
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01520

Chain	Residue	Details
A	ASP254
B	ASP254
B	HIS256
B	HIS280
B	HIS288
B	ASP302
B	PHE307
B	THR378
B	PHE385
B	LYS388
C	ASP254
A	HIS256
C	HIS256
C	HIS280
C	HIS288
C	ASP302
C	PHE307
C	THR378
C	PHE385
C	LYS388
A	HIS280
A	HIS288
A	ASP302
A	PHE307
A	THR378
A	PHE385
A	LYS388

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site_id	SWS_FT_FI2
Number of Residues	12
Details	SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_01520

Chain	Residue	Details
A	ARG48
C	LYS55
C	HIS280
C	THR379
A	LYS55
A	HIS280
A	THR379
B	ARG48
B	LYS55
B	HIS280
B	THR379
C	ARG48

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site_id	SWS_FT_FI3
Number of Residues	6
Details	SITE: Positions MEP for the nucleophilic attack => ECO:0000255|HAMAP-Rule:MF_01520

Chain	Residue	Details
A	ARG175
A	LYS227
B	ARG175
B	LYS227
C	ARG175
C	LYS227

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