8XFS

LGR4-RSPO2-ZNRF3 RING domain (1:2:2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
A	0016500	molecular_function	protein-hormone receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	326
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
C	LYS56-MET219
E	LYS56-MET219

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site_id	SWS_FT_FI2
Number of Residues	40
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
C	GLY220-ILE240
E	GLY220-ILE240
A	TYR725-ASN756

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site_id	SWS_FT_FI3
Number of Residues	20
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
A	PHE576-PHE596

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site_id	SWS_FT_FI4
Number of Residues	48
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	LEU597-VAL620
A	HIS683-SER703
A	SER778-LYS783

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site_id	SWS_FT_FI5
Number of Residues	20
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
A	ALA621-VAL641

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site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
A	PHE662-PHE682

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site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=5 => ECO:0000255

Chain	Residue	Details
A	LEU704-ILE724

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site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=6 => ECO:0000255

Chain	Residue	Details
A	CYS757-ILE777

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site_id	SWS_FT_FI9
Number of Residues	20
Details	TRANSMEM: Helical; Name=7 => ECO:0000255

Chain	Residue	Details
A	SER784-PHE804

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site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23756652

Chain	Residue	Details
A	ASN68
A	ASN199

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site_id	SWS_FT_FI11
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN294
A	ASN314
A	ASN505

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