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8X8N

Cryo-EM structure of the octreotide-bound Somatostatin receptor 5-Gi protein complex

Functional Information from GO Data
ChainGOidnamespacecontents
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0004930molecular_functionG protein-coupled receptor activity
R0004994molecular_functionsomatostatin receptor activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0007186biological_processG protein-coupled receptor signaling pathway
R0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
R0007218biological_processneuropeptide signaling pathway
R0008285biological_processnegative regulation of cell population proliferation
R0032467biological_processpositive regulation of cytokinesis
R0038170biological_processsomatostatin signaling pathway
R0042923molecular_functionneuropeptide binding
R0043005cellular_componentneuron projection
R0050796biological_processregulation of insulin secretion
R0071385biological_processcellular response to glucocorticoid stimulus
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSVfCLTVMSVDRYLaV
ChainResidueDetails
RTHR125-VAL141

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU75-SER89
BILE162-ILE176
BLEU290-ALA304
BVAL332-GLY346

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues75
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
RMET1-ALA38
RALA102-ARG113
RASP179-TRP197
RVAL274-ALA283

site_idSWS_FT_FI2
Number of Residues27
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
RARG39-LEU66

site_idSWS_FT_FI3
Number of Residues109
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
RARG67-ASN76
RASP136-LYS157
RLEU223-THR247
RASP309-LEU364

site_idSWS_FT_FI4
Number of Residues24
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
RILE77-ALA101

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RLEU114-VAL135

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RLEU158-ALA178

site_idSWS_FT_FI7
Number of Residues24
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RGLY198-LEU222

site_idSWS_FT_FI8
Number of Residues25
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RARG248-ALA273

site_idSWS_FT_FI9
Number of Residues24
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RGLY284-SER308

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000255
ChainResidueDetails
RSER325

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine; by ZDHHC5 => ECO:0000250
ChainResidueDetails
RCYS320

site_idSWS_FT_FI12
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN13
RASN26
RASN187

222926

PDB entries from 2024-07-24

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