8X5T
Crystal structure of Thermus thermophilus peptidyl-tRNA hydrolase in complex with adenosine 5'-monophosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004045 | molecular_function | peptidyl-tRNA hydrolase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0072344 | biological_process | rescue of stalled ribosome |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004045 | molecular_function | peptidyl-tRNA hydrolase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0072344 | biological_process | rescue of stalled ribosome |
| C | 0000049 | molecular_function | tRNA binding |
| C | 0003723 | molecular_function | RNA binding |
| C | 0004045 | molecular_function | peptidyl-tRNA hydrolase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0072344 | biological_process | rescue of stalled ribosome |
Functional Information from PROSITE/UniProt
| site_id | PS01195 |
| Number of Residues | 14 |
| Details | PEPT_TRNA_HYDROL_1 Peptidyl-tRNA hydrolase signature 1. YarTRHNlGfmVLD |
| Chain | Residue | Details |
| A | TYR14-ASP27 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00083 |
| Chain | Residue | Details |
| A | HIS19 | |
| B | HIS19 | |
| C | HIS19 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00083 |
| Chain | Residue | Details |
| A | TYR14 | |
| A | TYR55 | |
| A | ASN57 | |
| B | TYR14 | |
| B | TYR55 | |
| B | ASN57 | |
| C | TYR14 | |
| C | TYR55 | |
| C | ASN57 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | SITE: Discriminates between blocked and unblocked aminoacyl-tRNA => ECO:0000255|HAMAP-Rule:MF_00083 |
| Chain | Residue | Details |
| A | ASN9 | |
| B | ASN9 | |
| C | ASN9 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | SITE: Stabilizes the basic form of H active site to accept a proton => ECO:0000255|HAMAP-Rule:MF_00083 |
| Chain | Residue | Details |
| A | ASP82 | |
| B | ASP82 | |
| C | ASP82 |
