8X54
Cryo-EM structure of human gamma-secretase in complex with APP-C99
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26280335 |
| Chain | Residue | Details |
| D | MET1-LYS17 | |
| D | PHE37-VAL57 | |
| C | ASP140-LEU158 | |
| C | PRO208-SER213 | |
| B | LYS429-LEU432 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | INTRAMEM: Helical => ECO:0000269|PubMed:26280335 |
| Chain | Residue | Details |
| D | TYR18-TRP36 | |
| B | ILE133-LEU153 | |
| B | ILE167-TYR189 | |
| B | TYR195-LYS216 | |
| B | LEU221-LEU241 | |
| B | ILE249-VAL272 | |
| B | LEU381-SER401 | |
| B | ILE408-PHE428 | |
| B | PRO433-VAL453 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:26280335 |
| Chain | Residue | Details |
| D | TRP58-PHE78 | |
| C | TYR90-ALA118 | |
| C | ASP180-ARG186 | |
| C | SER235-ASP265 | |
| B | GLN454-ILE467 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:26280335, ECO:0000305|PubMed:12639958 |
| Chain | Residue | Details |
| D | GLN79-PRO101 | |
| A | ASN187 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:26280335 |
| Chain | Residue | Details |
| C | TYR69-ALA89 | |
| A | ASN264 | |
| A | ASN435 | |
| A | ASN464 | |
| A | ASN506 | |
| A | ASN530 | |
| A | ASN562 | |
| A | ASN573 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26280335 |
| Chain | Residue | Details |
| C | TYR119-ALA139 | |
| B | MET292 | |
| A | ASN417 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:26280335 |
| Chain | Residue | Details |
| C | THR159-PHE179 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:26280335 |
| Chain | Residue | Details |
| C | TYR187-ASN207 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:26280335 |
| Chain | Residue | Details |
| C | LEU214-GLY234 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97887 |
| Chain | Residue | Details |
| B | SER51 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:14576165 |
| Chain | Residue | Details |
| B | SER310 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:14576165 |
| Chain | Residue | Details |
| B | SER346 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER367 |
