8X32

The piccolo NuA4 bound to the H2A.Z nucleosome-H4KQ Complex with Ac-CoA at resetting state

Functional Information from GO Data

Chain	GOid	namespace	contents
M	0004364	molecular_function	glutathione transferase activity
M	0006749	biological_process	glutathione metabolic process
M	0016740	molecular_function	transferase activity

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA22-VAL28

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site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

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site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

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site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlILpGELaKHAVSEG

Chain	Residue	Details
D	ARG95-GLY117

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site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

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site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
L	PRO-291-ASN-274

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	ZN_FING: C2HC MYST-type; degenerate => ECO:0000255|PROSITE-ProRule:PRU01063

Chain	Residue	Details
K	ILE195-LEU220
D	LYS7
H	LYS6
H	LYS7

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000303|PubMed:12368900, ECO:0000303|PubMed:17223684, ECO:0000303|PubMed:18245364, ECO:0000303|PubMed:22020126, ECO:0000305

Chain	Residue	Details
K	GLU338
H	SER10
C	LYS4
C	LYS8
G	LYS-3
G	LYS2
G	LYS4
G	LYS8

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:11106757, ECO:0000269|PubMed:12368900, ECO:0000269|PubMed:22020126

Chain	Residue	Details
K	ALA303
K	GLN312
K	SER342

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Important for catalytic activity => ECO:0000305

Chain	Residue	Details
K	CYS304
H	LYS16
F	LYS31
F	LYS77

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
K	SER17
H	LYS17
E	LYS23
E	LYS56

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:22020126

Chain	Residue	Details
K	LYS262
H	LYS21

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site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:19113941

Chain	Residue	Details
D	LYS22
H	LYS22

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site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000269|PubMed:22389435

Chain	Residue	Details
D	LYS34
D	LYS46
H	LYS34
H	LYS46

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site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: N6,N6-dimethyllysine => ECO:0000269|PubMed:19113941

Chain	Residue	Details
D	LYS37
H	LYS37

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site_id	SWS_FT_FI10
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate

Chain	Residue	Details
D	LYS6
D	LYS7
H	LYS6
H	LYS7

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site_id	SWS_FT_FI11
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:10642555, ECO:0000269|PubMed:12535538, ECO:0000269|PubMed:12535539, ECO:0000269|PubMed:14660635, ECO:0000269|PubMed:15280549, ECO:0000269|PubMed:16432255

Chain	Residue	Details
D	LYS123
H	LYS123

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site_id	SWS_FT_FI12
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate => ECO:0000305

Chain	Residue	Details
D	LYS16
D	LYS17
H	LYS16
H	LYS17

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 525

Chain	Residue	Details
K	CYS304	covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor
K	GLU338	activator, proton acceptor, proton donor

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