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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8X2X

The piccolo NuA4 bound to the H2A.Z nucleosome complex at pre-H4-acetylation state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000500cellular_componentRNA polymerase I upstream activating factor complex
A0000786cellular_componentnucleosome
A0003677molecular_functionDNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0006325biological_processchromatin organization
A0006355biological_processregulation of DNA-templated transcription
A0006878biological_processintracellular copper ion homeostasis
A0008823molecular_functioncupric reductase (NADH) activity
A0009060biological_processaerobic respiration
A0009303biological_processrRNA transcription
A0042790biological_processnucleolar large rRNA transcription by RNA polymerase I
A0043505cellular_componentCENP-A containing nucleosome
A0043935biological_processsexual sporulation resulting in formation of a cellular spore
A0045943biological_processpositive regulation of transcription by RNA polymerase I
A0070911biological_processglobal genome nucleotide-excision repair
B0000500cellular_componentRNA polymerase I upstream activating factor complex
B0000786cellular_componentnucleosome
B0003677molecular_functionDNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005694cellular_componentchromosome
B0006325biological_processchromatin organization
B0006334biological_processnucleosome assembly
B0006355biological_processregulation of DNA-templated transcription
B0030527molecular_functionstructural constituent of chromatin
B0042790biological_processnucleolar large rRNA transcription by RNA polymerase I
B0042802molecular_functionidentical protein binding
B0045943biological_processpositive regulation of transcription by RNA polymerase I
C0000785cellular_componentchromatin
C0000786cellular_componentnucleosome
C0000791cellular_componenteuchromatin
C0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005694cellular_componentchromosome
C0006325biological_processchromatin organization
C0006338biological_processchromatin remodeling
C0006355biological_processregulation of DNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0006368biological_processtranscription elongation by RNA polymerase II
C0030466biological_processsilent mating-type cassette heterochromatin formation
C0030527molecular_functionstructural constituent of chromatin
C0031490molecular_functionchromatin DNA binding
C0031507biological_processheterochromatin formation
C0042802molecular_functionidentical protein binding
C0070481biological_processnuclear-transcribed mRNA catabolic process, non-stop decay
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000786cellular_componentnucleosome
D0003677molecular_functionDNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005694cellular_componentchromosome
D0006301biological_processDNA damage tolerance
D0006325biological_processchromatin organization
D0006355biological_processregulation of DNA-templated transcription
E0000500cellular_componentRNA polymerase I upstream activating factor complex
E0000786cellular_componentnucleosome
E0003677molecular_functionDNA binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005694cellular_componentchromosome
E0006325biological_processchromatin organization
E0006355biological_processregulation of DNA-templated transcription
E0006878biological_processintracellular copper ion homeostasis
E0008823molecular_functioncupric reductase (NADH) activity
E0009060biological_processaerobic respiration
E0009303biological_processrRNA transcription
E0042790biological_processnucleolar large rRNA transcription by RNA polymerase I
E0043505cellular_componentCENP-A containing nucleosome
E0043935biological_processsexual sporulation resulting in formation of a cellular spore
E0045943biological_processpositive regulation of transcription by RNA polymerase I
E0070911biological_processglobal genome nucleotide-excision repair
F0000500cellular_componentRNA polymerase I upstream activating factor complex
F0000786cellular_componentnucleosome
F0003677molecular_functionDNA binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005694cellular_componentchromosome
F0006325biological_processchromatin organization
F0006334biological_processnucleosome assembly
F0006355biological_processregulation of DNA-templated transcription
F0030527molecular_functionstructural constituent of chromatin
F0042790biological_processnucleolar large rRNA transcription by RNA polymerase I
F0042802molecular_functionidentical protein binding
F0045943biological_processpositive regulation of transcription by RNA polymerase I
G0000785cellular_componentchromatin
G0000786cellular_componentnucleosome
G0000791cellular_componenteuchromatin
G0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
G0003677molecular_functionDNA binding
G0003682molecular_functionchromatin binding
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005694cellular_componentchromosome
G0006325biological_processchromatin organization
G0006338biological_processchromatin remodeling
G0006355biological_processregulation of DNA-templated transcription
G0006357biological_processregulation of transcription by RNA polymerase II
G0006368biological_processtranscription elongation by RNA polymerase II
G0030466biological_processsilent mating-type cassette heterochromatin formation
G0030527molecular_functionstructural constituent of chromatin
G0031490molecular_functionchromatin DNA binding
G0031507biological_processheterochromatin formation
G0042802molecular_functionidentical protein binding
G0070481biological_processnuclear-transcribed mRNA catabolic process, non-stop decay
H0000122biological_processnegative regulation of transcription by RNA polymerase II
H0000786cellular_componentnucleosome
H0003677molecular_functionDNA binding
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005694cellular_componentchromosome
H0006301biological_processDNA damage tolerance
H0006325biological_processchromatin organization
H0006355biological_processregulation of DNA-templated transcription
K0000183biological_processrDNA heterochromatin formation
K0000785cellular_componentchromatin
K0000786cellular_componentnucleosome
K0003682molecular_functionchromatin binding
K0003712molecular_functiontranscription coregulator activity
K0004402molecular_functionhistone acetyltransferase activity
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0006281biological_processDNA repair
K0006325biological_processchromatin organization
K0006351biological_processDNA-templated transcription
K0006354biological_processDNA-templated transcription elongation
K0006357biological_processregulation of transcription by RNA polymerase II
K0006974biological_processDNA damage response
K0008270molecular_functionzinc ion binding
K0010485molecular_functionhistone H4 acetyltransferase activity
K0010629biological_processnegative regulation of gene expression
K0010867biological_processpositive regulation of triglyceride biosynthetic process
K0016239biological_processpositive regulation of macroautophagy
K0016740molecular_functiontransferase activity
K0032777cellular_componentpiccolo histone acetyltransferase complex
K0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
K0033554biological_processcellular response to stress
K0035267cellular_componentNuA4 histone acetyltransferase complex
K0051726biological_processregulation of cell cycle
K0061733molecular_functionprotein-lysine-acetyltransferase activity
K0106226molecular_functionpeptide 2-hydroxyisobutyryltransferase activity
K0140064molecular_functionpeptide crotonyltransferase activity
K0140068molecular_functionhistone crotonyltransferase activity
L0000123cellular_componenthistone acetyltransferase complex
L0004402molecular_functionhistone acetyltransferase activity
L0005634cellular_componentnucleus
L0006281biological_processDNA repair
L0006325biological_processchromatin organization
L0006338biological_processchromatin remodeling
L0006351biological_processDNA-templated transcription
L0006974biological_processDNA damage response
L0033100cellular_componentNuA3 histone acetyltransferase complex
L0035267cellular_componentNuA4 histone acetyltransferase complex
L1990467cellular_componentNuA3a histone acetyltransferase complex
L1990468cellular_componentNuA3b histone acetyltransferase complex
M0004364molecular_functionglutathione transferase activity
M0006749biological_processglutathione metabolic process
M0016740molecular_functiontransferase activity
Functional Information from PROSITE/UniProt
site_idPS00046
Number of Residues7
DetailsHISTONE_H2A Histone H2A signature. AGLqFPV
ChainResidueDetails
CALA22-VAL28
site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
BGLY14-HIS18
site_idPS00322
Number of Residues7
DetailsHISTONE_H3_1 Histone H3 signature 1. KAPRKQL
ChainResidueDetails
ALYS14-LEU20
site_idPS00357
Number of Residues23
DetailsHISTONE_H2B Histone H2B signature. REIQTavRlILpGELaKHAVSEG
ChainResidueDetails
DARG95-GLY117
site_idPS00959
Number of Residues9
DetailsHISTONE_H3_2 Histone H3 signature 2. PFqRLVREI
ChainResidueDetails
APRO66-ILE74
site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
ChainResidueDetails
LPRO-291-ASN-274
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues25
DetailsZinc finger: {"description":"C2HC MYST-type; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01063","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues21
DetailsMotif: {"description":"ESA1-RPD3 motif"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsActive site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"12368900","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"17223684","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"18245364","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"22020126","evidenceCode":"ECO:0000303"},{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues11
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11106757","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12368900","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22020126","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsSite: {"description":"Important for catalytic activity","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"PubMed","id":"22020126","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues6
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"16768447","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"N6-glutaryllysine","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues20
DetailsRegion: {"description":"Interaction with VPS72","evidences":[{"source":"PubMed","id":"16299513","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"N6,N6-dimethyllysine","evidences":[{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"10642555","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12535538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12535539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14660635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15280549","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16432255","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues2
DetailsM-CSA 525
ChainResidueDetails

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PDB entries from 2025-11-05

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