Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8X2H

Cryo-EM structure of the TcsL at pH 5.0 in its closed conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0008289	molecular_function	lipid binding
A	0009405	biological_process	obsolete pathogenesis
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0020002	cellular_component	host cell plasma membrane
A	0030430	cellular_component	host cell cytoplasm
A	0033644	cellular_component	host cell membrane
A	0035821	biological_process	modulation of process of another organism
A	0044164	cellular_component	host cell cytosol
A	0044174	cellular_component	host cell endosome
A	0044175	cellular_component	host cell endosome membrane
A	0046872	molecular_function	metal ion binding
A	0090729	molecular_function	toxin activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	372
Details	Domain: {"description":"GT44","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	207
Details	Domain: {"description":"Peptidase C80","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	20
Details	Repeat: {"description":"Cell wall-binding 11","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 12","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 13","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 14","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	15
Details	Repeat: {"description":"Cell wall-binding 15","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	22
Details	Repeat: {"description":"Cell wall-binding 16","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 17","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 18","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 19","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	19
Details	Repeat: {"description":"Cell wall-binding 20","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	90
Details	Region: {"description":"Four-helical bundle","evidences":[{"source":"UniProtKB","id":"Q46342","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	372
Details	Region: {"description":"Glucosyltransferase region","evidences":[{"source":"UniProtKB","id":"Q46342","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	255
Details	Region: {"description":"Autoprocessing region","evidences":[{"source":"UniProtKB","id":"Q46342","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	700
Details	Region: {"description":"Translocation region","evidences":[{"source":"UniProtKB","id":"Q46342","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	33
Details	Region: {"description":"Interaction with host SEMA6A and SEMA6B","evidences":[{"source":"UniProtKB","id":"P0DUB4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	1
Details	Active site: {"description":"For protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	1
Details	Active site: {"description":"Nucleophile; for protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q46342","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P16154","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P18177","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	1
Details	Site: {"description":"Cleavage; by autolysis","evidences":[{"source":"UniProtKB","id":"P18177","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)