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8X0O

Crystal structure of Tyrosine decarboxylase H203F mutant in complex with the cofactor PLP and Tyrosine

Functional Information from GO Data
ChainGOidnamespacecontents
A0004058molecular_functionaromatic-L-amino-acid decarboxylase activity
A0004837molecular_functiontyrosine decarboxylase activity
A0005737cellular_componentcytoplasm
A0006520biological_processamino acid metabolic process
A0016829molecular_functionlyase activity
A0016830molecular_functioncarbon-carbon lyase activity
A0016831molecular_functioncarboxy-lyase activity
A0019752biological_processcarboxylic acid metabolic process
A0030170molecular_functionpyridoxal phosphate binding
A0036467molecular_function5-hydroxy-L-tryptophan decarboxylase activity
A0036468molecular_functionL-dopa decarboxylase activity
B0004058molecular_functionaromatic-L-amino-acid decarboxylase activity
B0004837molecular_functiontyrosine decarboxylase activity
B0005737cellular_componentcytoplasm
B0006520biological_processamino acid metabolic process
B0016829molecular_functionlyase activity
B0016830molecular_functioncarbon-carbon lyase activity
B0016831molecular_functioncarboxy-lyase activity
B0019752biological_processcarboxylic acid metabolic process
B0030170molecular_functionpyridoxal phosphate binding
B0036467molecular_function5-hydroxy-L-tryptophan decarboxylase activity
B0036468molecular_functionL-dopa decarboxylase activity
C0004058molecular_functionaromatic-L-amino-acid decarboxylase activity
C0004837molecular_functiontyrosine decarboxylase activity
C0005737cellular_componentcytoplasm
C0006520biological_processamino acid metabolic process
C0016829molecular_functionlyase activity
C0016830molecular_functioncarbon-carbon lyase activity
C0016831molecular_functioncarboxy-lyase activity
C0019752biological_processcarboxylic acid metabolic process
C0030170molecular_functionpyridoxal phosphate binding
C0036467molecular_function5-hydroxy-L-tryptophan decarboxylase activity
C0036468molecular_functionL-dopa decarboxylase activity
D0004058molecular_functionaromatic-L-amino-acid decarboxylase activity
D0004837molecular_functiontyrosine decarboxylase activity
D0005737cellular_componentcytoplasm
D0006520biological_processamino acid metabolic process
D0016829molecular_functionlyase activity
D0016830molecular_functioncarbon-carbon lyase activity
D0016831molecular_functioncarboxy-lyase activity
D0019752biological_processcarboxylic acid metabolic process
D0030170molecular_functionpyridoxal phosphate binding
D0036467molecular_function5-hydroxy-L-tryptophan decarboxylase activity
D0036468molecular_functionL-dopa decarboxylase activity
E0004058molecular_functionaromatic-L-amino-acid decarboxylase activity
E0004837molecular_functiontyrosine decarboxylase activity
E0005737cellular_componentcytoplasm
E0006520biological_processamino acid metabolic process
E0016829molecular_functionlyase activity
E0016830molecular_functioncarbon-carbon lyase activity
E0016831molecular_functioncarboxy-lyase activity
E0019752biological_processcarboxylic acid metabolic process
E0030170molecular_functionpyridoxal phosphate binding
E0036467molecular_function5-hydroxy-L-tryptophan decarboxylase activity
E0036468molecular_functionL-dopa decarboxylase activity
F0004058molecular_functionaromatic-L-amino-acid decarboxylase activity
F0004837molecular_functiontyrosine decarboxylase activity
F0005737cellular_componentcytoplasm
F0006520biological_processamino acid metabolic process
F0016829molecular_functionlyase activity
F0016830molecular_functioncarbon-carbon lyase activity
F0016831molecular_functioncarboxy-lyase activity
F0019752biological_processcarboxylic acid metabolic process
F0030170molecular_functionpyridoxal phosphate binding
F0036467molecular_function5-hydroxy-L-tryptophan decarboxylase activity
F0036468molecular_functionL-dopa decarboxylase activity
Functional Information from PROSITE/UniProt
site_idPS00392
Number of Residues22
DetailsDDC_GAD_HDC_YDC DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. SFsLnahKWFfTtLDCccLWvK
ChainResidueDetails
ASER312-LYS333

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsModified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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