8X0H
Human FL Metabotropic glutamate receptor 5, mGlu5-5M with quisqualate, Rcc conformation
Functional Information from PROSITE/UniProt
| site_id | PS00979 |
| Number of Residues | 19 |
| Details | G_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VqNLLqLFnIPQIAySATS |
| Chain | Residue | Details |
| A | VAL158-SER176 |
| site_id | PS00980 |
| Number of Residues | 23 |
| Details | G_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCWtCtpCkeneYvf...DeyTCkaC |
| Chain | Residue | Details |
| A | CYS530-CYS552 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1178 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:25042998 |
| Chain | Residue | Details |
| A | SER22-PRO580 | |
| A | ALA637-CYS644 | |
| A | GLU715-ASN737 | |
| A | ASN796-LYS798 | |
| B | SER22-PRO580 | |
| B | ALA637-CYS644 | |
| B | GLU715-ASN737 | |
| B | ASN796-LYS798 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=1 |
| Chain | Residue | Details |
| A | ILE581-ILE603 | |
| B | ILE581-ILE603 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 92 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25042998 |
| Chain | Residue | Details |
| A | TYR604-SER613 | |
| A | ARG668-GLN693 | |
| A | LYS760-LYS772 | |
| B | TYR604-SER613 | |
| B | ARG668-GLN693 | |
| B | LYS760-LYS772 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=2 |
| Chain | Residue | Details |
| A | SER614-ILE636 | |
| B | SER614-ILE636 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=3 |
| Chain | Residue | Details |
| A | TYR645-ASN667 | |
| B | TYR645-ASN667 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=4 |
| Chain | Residue | Details |
| A | LEU694-MET714 | |
| B | LEU694-MET714 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=5 |
| Chain | Residue | Details |
| A | LEU738-PHE759 | |
| B | LEU738-PHE759 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=6 |
| Chain | Residue | Details |
| A | TYR773-SER795 | |
| B | TYR773-SER795 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=7 |
| Chain | Residue | Details |
| A | ALA799-PRO820 | |
| B | ALA799-PRO820 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|Ref.8 |
| Chain | Residue | Details |
| A | TYR64 | |
| B | LYS396 | |
| A | SER152 | |
| A | TYR223 | |
| A | ASP305 | |
| A | LYS396 | |
| B | TYR64 | |
| B | SER152 | |
| B | TYR223 | |
| B | ASP305 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | SER173 | |
| B | SER173 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 10 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN88 | |
| B | ASN734 | |
| A | ASN210 | |
| A | ASN378 | |
| A | ASN382 | |
| A | ASN734 | |
| B | ASN88 | |
| B | ASN210 | |
| B | ASN378 | |
| B | ASN382 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|Ref.8 |
| Chain | Residue | Details |
| A | ALA445 | |
| B | ALA445 |
