8X02

E2 core of 2-oxoglutarate dehydrogenase complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006099	biological_process	tricarboxylic acid cycle
A	0006103	biological_process	2-oxoglutarate metabolic process
A	0006104	biological_process	succinyl-CoA metabolic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
A	0045252	cellular_component	oxoglutarate dehydrogenase complex
B	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006099	biological_process	tricarboxylic acid cycle
B	0006103	biological_process	2-oxoglutarate metabolic process
B	0006104	biological_process	succinyl-CoA metabolic process
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
B	0045252	cellular_component	oxoglutarate dehydrogenase complex
C	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006099	biological_process	tricarboxylic acid cycle
C	0006103	biological_process	2-oxoglutarate metabolic process
C	0006104	biological_process	succinyl-CoA metabolic process
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
C	0045252	cellular_component	oxoglutarate dehydrogenase complex
D	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
D	0005634	cellular_component	nucleus
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006099	biological_process	tricarboxylic acid cycle
D	0006103	biological_process	2-oxoglutarate metabolic process
D	0006104	biological_process	succinyl-CoA metabolic process
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
D	0045252	cellular_component	oxoglutarate dehydrogenase complex
E	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
E	0005634	cellular_component	nucleus
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0006099	biological_process	tricarboxylic acid cycle
E	0006103	biological_process	2-oxoglutarate metabolic process
E	0006104	biological_process	succinyl-CoA metabolic process
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
E	0045252	cellular_component	oxoglutarate dehydrogenase complex
F	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
F	0005634	cellular_component	nucleus
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006099	biological_process	tricarboxylic acid cycle
F	0006103	biological_process	2-oxoglutarate metabolic process
F	0006104	biological_process	succinyl-CoA metabolic process
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
F	0045252	cellular_component	oxoglutarate dehydrogenase complex
G	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
G	0005634	cellular_component	nucleus
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0006099	biological_process	tricarboxylic acid cycle
G	0006103	biological_process	2-oxoglutarate metabolic process
G	0006104	biological_process	succinyl-CoA metabolic process
G	0016740	molecular_function	transferase activity
G	0016746	molecular_function	acyltransferase activity
G	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
G	0045252	cellular_component	oxoglutarate dehydrogenase complex
H	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
H	0005634	cellular_component	nucleus
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0006099	biological_process	tricarboxylic acid cycle
H	0006103	biological_process	2-oxoglutarate metabolic process
H	0006104	biological_process	succinyl-CoA metabolic process
H	0016740	molecular_function	transferase activity
H	0016746	molecular_function	acyltransferase activity
H	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
H	0045252	cellular_component	oxoglutarate dehydrogenase complex
I	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
I	0005634	cellular_component	nucleus
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0006099	biological_process	tricarboxylic acid cycle
I	0006103	biological_process	2-oxoglutarate metabolic process
I	0006104	biological_process	succinyl-CoA metabolic process
I	0016740	molecular_function	transferase activity
I	0016746	molecular_function	acyltransferase activity
I	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
I	0045252	cellular_component	oxoglutarate dehydrogenase complex
J	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
J	0005634	cellular_component	nucleus
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0006099	biological_process	tricarboxylic acid cycle
J	0006103	biological_process	2-oxoglutarate metabolic process
J	0006104	biological_process	succinyl-CoA metabolic process
J	0016740	molecular_function	transferase activity
J	0016746	molecular_function	acyltransferase activity
J	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
J	0045252	cellular_component	oxoglutarate dehydrogenase complex
K	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
K	0005634	cellular_component	nucleus
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0006099	biological_process	tricarboxylic acid cycle
K	0006103	biological_process	2-oxoglutarate metabolic process
K	0006104	biological_process	succinyl-CoA metabolic process
K	0016740	molecular_function	transferase activity
K	0016746	molecular_function	acyltransferase activity
K	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
K	0045252	cellular_component	oxoglutarate dehydrogenase complex
L	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
L	0005634	cellular_component	nucleus
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0006099	biological_process	tricarboxylic acid cycle
L	0006103	biological_process	2-oxoglutarate metabolic process
L	0006104	biological_process	succinyl-CoA metabolic process
L	0016740	molecular_function	transferase activity
L	0016746	molecular_function	acyltransferase activity
L	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
L	0045252	cellular_component	oxoglutarate dehydrogenase complex
M	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
M	0005634	cellular_component	nucleus
M	0005739	cellular_component	mitochondrion
M	0005759	cellular_component	mitochondrial matrix
M	0006099	biological_process	tricarboxylic acid cycle
M	0006103	biological_process	2-oxoglutarate metabolic process
M	0006104	biological_process	succinyl-CoA metabolic process
M	0016740	molecular_function	transferase activity
M	0016746	molecular_function	acyltransferase activity
M	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
M	0045252	cellular_component	oxoglutarate dehydrogenase complex
N	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
N	0005634	cellular_component	nucleus
N	0005739	cellular_component	mitochondrion
N	0005759	cellular_component	mitochondrial matrix
N	0006099	biological_process	tricarboxylic acid cycle
N	0006103	biological_process	2-oxoglutarate metabolic process
N	0006104	biological_process	succinyl-CoA metabolic process
N	0016740	molecular_function	transferase activity
N	0016746	molecular_function	acyltransferase activity
N	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
N	0045252	cellular_component	oxoglutarate dehydrogenase complex
O	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
O	0005634	cellular_component	nucleus
O	0005739	cellular_component	mitochondrion
O	0005759	cellular_component	mitochondrial matrix
O	0006099	biological_process	tricarboxylic acid cycle
O	0006103	biological_process	2-oxoglutarate metabolic process
O	0006104	biological_process	succinyl-CoA metabolic process
O	0016740	molecular_function	transferase activity
O	0016746	molecular_function	acyltransferase activity
O	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
O	0045252	cellular_component	oxoglutarate dehydrogenase complex
P	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
P	0005634	cellular_component	nucleus
P	0005739	cellular_component	mitochondrion
P	0005759	cellular_component	mitochondrial matrix
P	0006099	biological_process	tricarboxylic acid cycle
P	0006103	biological_process	2-oxoglutarate metabolic process
P	0006104	biological_process	succinyl-CoA metabolic process
P	0016740	molecular_function	transferase activity
P	0016746	molecular_function	acyltransferase activity
P	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
P	0045252	cellular_component	oxoglutarate dehydrogenase complex
Q	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
Q	0005634	cellular_component	nucleus
Q	0005739	cellular_component	mitochondrion
Q	0005759	cellular_component	mitochondrial matrix
Q	0006099	biological_process	tricarboxylic acid cycle
Q	0006103	biological_process	2-oxoglutarate metabolic process
Q	0006104	biological_process	succinyl-CoA metabolic process
Q	0016740	molecular_function	transferase activity
Q	0016746	molecular_function	acyltransferase activity
Q	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
Q	0045252	cellular_component	oxoglutarate dehydrogenase complex
R	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
R	0005634	cellular_component	nucleus
R	0005739	cellular_component	mitochondrion
R	0005759	cellular_component	mitochondrial matrix
R	0006099	biological_process	tricarboxylic acid cycle
R	0006103	biological_process	2-oxoglutarate metabolic process
R	0006104	biological_process	succinyl-CoA metabolic process
R	0016740	molecular_function	transferase activity
R	0016746	molecular_function	acyltransferase activity
R	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
R	0045252	cellular_component	oxoglutarate dehydrogenase complex
S	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
S	0005634	cellular_component	nucleus
S	0005739	cellular_component	mitochondrion
S	0005759	cellular_component	mitochondrial matrix
S	0006099	biological_process	tricarboxylic acid cycle
S	0006103	biological_process	2-oxoglutarate metabolic process
S	0006104	biological_process	succinyl-CoA metabolic process
S	0016740	molecular_function	transferase activity
S	0016746	molecular_function	acyltransferase activity
S	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
S	0045252	cellular_component	oxoglutarate dehydrogenase complex
T	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
T	0005634	cellular_component	nucleus
T	0005739	cellular_component	mitochondrion
T	0005759	cellular_component	mitochondrial matrix
T	0006099	biological_process	tricarboxylic acid cycle
T	0006103	biological_process	2-oxoglutarate metabolic process
T	0006104	biological_process	succinyl-CoA metabolic process
T	0016740	molecular_function	transferase activity
T	0016746	molecular_function	acyltransferase activity
T	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
T	0045252	cellular_component	oxoglutarate dehydrogenase complex
U	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
U	0005634	cellular_component	nucleus
U	0005739	cellular_component	mitochondrion
U	0005759	cellular_component	mitochondrial matrix
U	0006099	biological_process	tricarboxylic acid cycle
U	0006103	biological_process	2-oxoglutarate metabolic process
U	0006104	biological_process	succinyl-CoA metabolic process
U	0016740	molecular_function	transferase activity
U	0016746	molecular_function	acyltransferase activity
U	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
U	0045252	cellular_component	oxoglutarate dehydrogenase complex
V	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
V	0005634	cellular_component	nucleus
V	0005739	cellular_component	mitochondrion
V	0005759	cellular_component	mitochondrial matrix
V	0006099	biological_process	tricarboxylic acid cycle
V	0006103	biological_process	2-oxoglutarate metabolic process
V	0006104	biological_process	succinyl-CoA metabolic process
V	0016740	molecular_function	transferase activity
V	0016746	molecular_function	acyltransferase activity
V	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
V	0045252	cellular_component	oxoglutarate dehydrogenase complex
W	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
W	0005634	cellular_component	nucleus
W	0005739	cellular_component	mitochondrion
W	0005759	cellular_component	mitochondrial matrix
W	0006099	biological_process	tricarboxylic acid cycle
W	0006103	biological_process	2-oxoglutarate metabolic process
W	0006104	biological_process	succinyl-CoA metabolic process
W	0016740	molecular_function	transferase activity
W	0016746	molecular_function	acyltransferase activity
W	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
W	0045252	cellular_component	oxoglutarate dehydrogenase complex
X	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
X	0005634	cellular_component	nucleus
X	0005739	cellular_component	mitochondrion
X	0005759	cellular_component	mitochondrial matrix
X	0006099	biological_process	tricarboxylic acid cycle
X	0006103	biological_process	2-oxoglutarate metabolic process
X	0006104	biological_process	succinyl-CoA metabolic process
X	0016740	molecular_function	transferase activity
X	0016746	molecular_function	acyltransferase activity
X	0033512	biological_process	L-lysine catabolic process to acetyl-CoA via saccharopine
X	0045252	cellular_component	oxoglutarate dehydrogenase complex

Functional Information from PROSITE/UniProt

site_id	PS00189
Number of Residues	30
Details	LIPOYL 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. GdtVaedEVVceIETdKTSvqVpspanGvI

Chain	Residue	Details
A	GLY-125-ILE-96

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5568
Details	Region: {"description":"Catalytic"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	48
Details	Active site: {"evidences":[{"source":"PubMed","id":"10806400","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	120
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D2G2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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