8WXR
Structure of WDR5 in complex with WIN motif containing MBD3C F47A
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV |
| Chain | Residue | Details |
| A | LEU102-VAL116 | |
| A | ILE144-VAL158 | |
| A | ILE186-THR200 | |
| A | ILE274-LEU288 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | SITE: Important for interaction with histone H3 |
| Chain | Residue | Details |
| A | ASP107 | |
| A | PHE133 | |
| A | PHE263 | |
| A | GLU322 | |
| B | ASP107 | |
| B | PHE133 | |
| B | PHE263 | |
| B | GLU322 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS112 | |
| B | LYS112 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS27 | |
| A | LYS46 | |
| B | LYS27 | |
| B | LYS46 |
