8WX1
Cryo-EM structure of mouse SLC15A3 (outward-facing open)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0006857 | biological_process | oligopeptide transport |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0015647 | molecular_function | peptidoglycan transmembrane transporter activity |
| A | 0015835 | biological_process | peptidoglycan transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070434 | biological_process | positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway |
| A | 0071916 | molecular_function | dipeptide transmembrane transporter activity |
| A | 0140206 | biological_process | dipeptide import across plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS01023 |
| Number of Residues | 13 |
| Details | PTR2_2 PTR2 family proton/oligopeptide symporters signature 2. FnwFYWsINLGAI |
| Chain | Residue | Details |
| A | PHE199-ILE211 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"39719710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 78 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39719710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 15 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39719710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 79 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39719710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39719710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 14 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"39719710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"39719710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"39719710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"39719710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 14 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"39719710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"39719710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 9 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"39719710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"39719710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"39719710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
