8WUA

cryo-EM structure of human TMEM63A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0005227	molecular_function	calcium-activated cation channel activity
A	0016020	cellular_component	membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	280
Details	TRANSMEM: Helical => ECO:0000305|PubMed:37543036, ECO:0007744|PDB:8EHW

Chain	Residue	Details
A	THR52-ARG74
A	GLY662-ARG689
A	PRO695-LEU709
A	ASP135-SER167
A	LEU192-SER217
A	ARG417-SER444
A	ILE463-GLU490
A	SER496-LEU532
A	PHE555-ILE586
A	PHE607-TYR624
A	PRO629-TYR651

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site_id	SWS_FT_FI2
Number of Residues	289
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	PHE75-GLU134
A	ILE218-LEU416
A	SER491-LYS495
A	MET587-GLU606
A	PHE652-LYS661

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site_id	SWS_FT_FI3
Number of Residues	68
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	GLY168-ASP191
A	THR445-ILE462
A	PHE533-ALA554
A	SER625-CYS628
A	LEU690-ALA694

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498

Chain	Residue	Details
A	ASN38
A	ASN450

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