8WSA

Cryo-EM Structure of Mouse TLR4/MD-2/DLAM5 Complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0001530	molecular_function	lipopolysaccharide binding
C	0001875	molecular_function	lipopolysaccharide immune receptor activity
C	0002221	biological_process	pattern recognition receptor signaling pathway
C	0002224	biological_process	toll-like receptor signaling pathway
C	0002376	biological_process	immune system process
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005886	cellular_component	plasma membrane
C	0006954	biological_process	inflammatory response
C	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
C	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
C	0032496	biological_process	response to lipopolysaccharide
C	0032497	biological_process	detection of lipopolysaccharide
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0034142	biological_process	toll-like receptor 4 signaling pathway
C	0035662	molecular_function	Toll-like receptor 4 binding
C	0043235	cellular_component	receptor complex
C	0045087	biological_process	innate immune response
C	0046696	cellular_component	lipopolysaccharide receptor complex
C	0071222	biological_process	cellular response to lipopolysaccharide
D	0001530	molecular_function	lipopolysaccharide binding
D	0001875	molecular_function	lipopolysaccharide immune receptor activity
D	0002221	biological_process	pattern recognition receptor signaling pathway
D	0002224	biological_process	toll-like receptor signaling pathway
D	0002376	biological_process	immune system process
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005886	cellular_component	plasma membrane
D	0006954	biological_process	inflammatory response
D	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
D	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
D	0032496	biological_process	response to lipopolysaccharide
D	0032497	biological_process	detection of lipopolysaccharide
D	0032760	biological_process	positive regulation of tumor necrosis factor production
D	0034142	biological_process	toll-like receptor 4 signaling pathway
D	0035662	molecular_function	Toll-like receptor 4 binding
D	0043235	cellular_component	receptor complex
D	0045087	biological_process	innate immune response
D	0046696	cellular_component	lipopolysaccharide receptor complex
D	0071222	biological_process	cellular response to lipopolysaccharide

Functional Information from PROSITE/UniProt

site_id	PS00159
Number of Residues	10
Details	ALDOLASE_KDPG_KHG_1 KDPG and KHG aldolases active site. GIklhELTLR

Chain	Residue	Details
A	GLY224-ARG233

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64

Chain	Residue	Details
C	ASN26
B	ASN34
B	ASN75
B	ASN172
B	ASN204
B	ASN237
B	ASN307
B	ASN492
B	ASN524
B	ASN572
D	ASN26
A	ASN172
A	ASN204
A	ASN237
A	ASN307
A	ASN492
A	ASN524
A	ASN572

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912

Chain	Residue	Details
C	ASN114
B	ASN622
C	ASN150
D	ASN114
D	ASN150
A	ASN622
B	ASN495
B	ASN575
B	ASN613
B	ASN621

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