8WRA

The Crystal Structure of CASP1 from Biortus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00455
Number of Residues	12
Details	AMP_BINDING Putative AMP-binding domain signature. MPTSSGSEGnVK

Chain	Residue	Details
A	MET123-LYS134

---

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HktsdStfLvFMSHG

Chain	Residue	Details
A	HIS224-GLY238

---

site_id	PS01122
Number of Residues	12
Details	CASPASE_CYS Caspase family cysteine active site. KPKVIIIQACRG

Chain	Residue	Details
A	LYS276-GLY287

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:1574116

Chain	Residue	Details
A	HIS237

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:1574116, ECO:0000305|PubMed:32051255

Chain	Residue	Details
A	CYS285

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P29452

Chain	Residue	Details
A	SER302

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:30065070

Chain	Residue	Details
A	LYS134

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 718

Chain	Residue	Details
A	HIS237	proton acceptor, proton donor
A	GLY238	electrostatic stabiliser
A	CYS285	nucleofuge, nucleophile, proton acceptor, proton donor
A	ARG286	electrostatic stabiliser
A	GLU390	electrostatic stabiliser

---