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8WPF

Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with exogenous DNA bearing one abasic site

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003824molecular_functioncatalytic activity
A0003887molecular_functionDNA-directed DNA polymerase activity
A0006260biological_processDNA replication
A0006310biological_processDNA recombination
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0016787molecular_functionhydrolase activity
A0019079biological_processviral genome replication
A0039693biological_processviral DNA genome replication
B0006260biological_processDNA replication
C0003677molecular_functionDNA binding
C0006281biological_processDNA repair
C0006974biological_processDNA damage response
C0016787molecular_functionhydrolase activity
C0016799molecular_functionhydrolase activity, hydrolyzing N-glycosyl compounds
D0019031cellular_componentviral envelope
D0030430cellular_componenthost cell cytoplasm
D0044423cellular_componentvirion component
E0019031cellular_componentviral envelope
E0030430cellular_componenthost cell cytoplasm
E0044423cellular_componentvirion component
F0019031cellular_componentviral envelope
F0030430cellular_componenthost cell cytoplasm
F0044423cellular_componentvirion component
G0019031cellular_componentviral envelope
G0030430cellular_componenthost cell cytoplasm
G0044423cellular_componentvirion component
Functional Information from PROSITE/UniProt
site_idPS00116
Number of Residues9
DetailsDNA_POLYMERASE_B DNA polymerase family B signature. YGDTDSVFT
ChainResidueDetails
ATYR749-THR757

site_idPS00130
Number of Residues10
DetailsU_DNA_GLYCOSYLASE Uracil-DNA glycosylase signature. RVCVcGIDPY
ChainResidueDetails
CARG61-TYR70

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PDB entries from 2025-06-18

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