8WNS
Cryo EM map of SLC7A10 in the apo state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0003333 | biological_process | amino acid transmembrane transport |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006865 | biological_process | amino acid transport |
| B | 0015175 | molecular_function | neutral L-amino acid transmembrane transporter activity |
| B | 0015179 | molecular_function | L-amino acid transmembrane transporter activity |
| B | 0015194 | molecular_function | L-serine transmembrane transporter activity |
| B | 0015804 | biological_process | neutral amino acid transport |
| B | 0015816 | biological_process | glycine transport |
| B | 0015825 | biological_process | L-serine transport |
| B | 0016020 | cellular_component | membrane |
| B | 0042941 | biological_process | D-alanine transmembrane transport |
| B | 0042942 | biological_process | D-serine transmembrane transport |
| B | 0060094 | biological_process | positive regulation of synaptic transmission, glycinergic |
| B | 1902475 | biological_process | L-alpha-amino acid transmembrane transport |
| B | 1903444 | biological_process | negative regulation of brown fat cell differentiation |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 180 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| B | ILE40-ILE60 | |
| B | VAL72-CYS92 | |
| B | ILE113-THR133 | |
| B | ALA268-PHE288 | |
| B | LEU310-ILE330 | |
| B | CYS362-GLY382 | |
| B | ILE388-LEU408 | |
| B | LEU424-SER444 | |
| B | VAL448-PHE468 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000269|PubMed:30867591 |
| Chain | Residue | Details |
| A | LEU186-VAL206 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 424 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591 |
| Chain | Residue | Details |
| A | ARG207-ALA631 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000269|Ref.10, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | MET1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER104 | |
| A | SER135 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q794F9 |
| Chain | Residue | Details |
| A | THR107 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER166 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphoserine => ECO:0000305|PubMed:19065266 |
| Chain | Residue | Details |
| A | SER407 | |
| A | SER409 | |
| A | SER411 | |
| A | SER528 | |
| A | SER532 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | ASN366 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | ASN382 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | ASN425 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMH, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | ASN507 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
| Chain | Residue | Details |
| A | LYS148 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211 |
| Chain | Residue | Details |
| A | LYS167 |
