8WM9
Fzd4/DEP complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0016020 | cellular_component | membrane |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0042813 | molecular_function | Wnt receptor activity |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0007166 | biological_process | cell surface receptor signaling pathway |
| B | 0016020 | cellular_component | membrane |
| B | 0016055 | biological_process | Wnt signaling pathway |
| B | 0042813 | molecular_function | Wnt receptor activity |
| C | 0001843 | biological_process | neural tube closure |
| C | 0001947 | biological_process | heart looping |
| C | 0003151 | biological_process | outflow tract morphogenesis |
| C | 0005109 | molecular_function | frizzled binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0007264 | biological_process | small GTPase-mediated signal transduction |
| C | 0007379 | biological_process | segment specification |
| C | 0007507 | biological_process | heart development |
| C | 0016055 | biological_process | Wnt signaling pathway |
| C | 0016328 | cellular_component | lateral plasma membrane |
| C | 0019901 | molecular_function | protein kinase binding |
| C | 0019904 | molecular_function | protein domain specific binding |
| C | 0030136 | cellular_component | clathrin-coated vesicle |
| C | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| C | 0031267 | molecular_function | small GTPase binding |
| C | 0031410 | cellular_component | cytoplasmic vesicle |
| C | 0032956 | biological_process | regulation of actin cytoskeleton organization |
| C | 0035282 | biological_process | segmentation |
| C | 0035556 | biological_process | intracellular signal transduction |
| C | 0035567 | biological_process | non-canonical Wnt signaling pathway |
| C | 0042127 | biological_process | regulation of cell population proliferation |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0045177 | cellular_component | apical part of cell |
| C | 0045334 | cellular_component | clathrin-coated endocytic vesicle |
| C | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| C | 0046330 | biological_process | positive regulation of JNK cascade |
| C | 0060070 | biological_process | canonical Wnt signaling pathway |
| C | 0060071 | biological_process | Wnt signaling pathway, planar cell polarity pathway |
| C | 0150012 | biological_process | positive regulation of neuron projection arborization |
| C | 1901798 | biological_process | positive regulation of signal transduction by p53 class mediator |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 60 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 26 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 66 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 56 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 58 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 68 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 56 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | Motif: {"description":"Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 74 |
| Details | Domain: {"description":"DEP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00066","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
