8WM9

Fzd4/DEP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0007166	biological_process	cell surface receptor signaling pathway
A	0016020	cellular_component	membrane
A	0016055	biological_process	Wnt signaling pathway
A	0042813	molecular_function	Wnt receptor activity
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0007166	biological_process	cell surface receptor signaling pathway
B	0016020	cellular_component	membrane
B	0016055	biological_process	Wnt signaling pathway
B	0042813	molecular_function	Wnt receptor activity
C	0001843	biological_process	neural tube closure
C	0001947	biological_process	heart looping
C	0003007	biological_process	heart morphogenesis
C	0003151	biological_process	outflow tract morphogenesis
C	0005109	molecular_function	frizzled binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006355	biological_process	regulation of DNA-templated transcription
C	0007264	biological_process	small GTPase-mediated signal transduction
C	0007379	biological_process	segment specification
C	0007507	biological_process	heart development
C	0008104	biological_process	intracellular protein localization
C	0016055	biological_process	Wnt signaling pathway
C	0016235	cellular_component	aggresome
C	0016328	cellular_component	lateral plasma membrane
C	0016604	cellular_component	nuclear body
C	0019901	molecular_function	protein kinase binding
C	0019904	molecular_function	protein domain specific binding
C	0022007	biological_process	convergent extension involved in neural plate elongation
C	0030136	cellular_component	clathrin-coated vesicle
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031267	molecular_function	small GTPase binding
C	0031410	cellular_component	cytoplasmic vesicle
C	0032956	biological_process	regulation of actin cytoskeleton organization
C	0035282	biological_process	segmentation
C	0035556	biological_process	intracellular signal transduction
C	0035567	biological_process	non-canonical Wnt signaling pathway
C	0042127	biological_process	regulation of cell population proliferation
C	0042802	molecular_function	identical protein binding
C	0045177	cellular_component	apical part of cell
C	0045334	cellular_component	clathrin-coated endocytic vesicle
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046330	biological_process	positive regulation of JNK cascade
C	0060029	biological_process	convergent extension involved in organogenesis
C	0060070	biological_process	canonical Wnt signaling pathway
C	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
C	0090103	biological_process	cochlea morphogenesis
C	0150012	biological_process	positive regulation of neuron projection arborization
C	1901798	biological_process	positive regulation of signal transduction by p53 class mediator

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	26
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	66
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	58
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"30135577","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	10
Details	Motif: {"description":"Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	74
Details	Domain: {"description":"DEP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00066","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---