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8WLA

Cryo-EM structure of the beta-1,3-glucan synthase FKS1-Rho1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000131cellular_componentincipient cellular bud site
A0000148cellular_component1,3-beta-D-glucan synthase complex
A0000166molecular_functionnucleotide binding
A0000329cellular_componentfungal-type vacuole membrane
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005777cellular_componentperoxisome
A0005778cellular_componentperoxisomal membrane
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005933cellular_componentcellular bud
A0005934cellular_componentcellular bud tip
A0005935cellular_componentcellular bud neck
A0006075biological_process(1->3)-beta-D-glucan biosynthetic process
A0007015biological_processactin filament organization
A0007117biological_processbudding cell bud growth
A0007165biological_processsignal transduction
A0007264biological_processsmall GTPase-mediated signal transduction
A0008047molecular_functionenzyme activator activity
A0008361biological_processregulation of cell size
A0009272biological_processfungal-type cell wall biogenesis
A0009277cellular_componentfungal-type cell wall
A0010008cellular_componentendosome membrane
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019901molecular_functionprotein kinase binding
A0030036biological_processactin cytoskeleton organization
A0030476biological_processascospore wall assembly
A0031160cellular_componentspore wall
A0031681molecular_functionG-protein beta-subunit binding
A0032186biological_processcellular bud neck septin ring organization
A0032880biological_processregulation of protein localization
A0032889biological_processregulation of vacuole fusion, non-autophagic
A0032956biological_processregulation of actin cytoskeleton organization
A0043332cellular_componentmating projection tip
A0045807biological_processpositive regulation of endocytosis
A0060178biological_processregulation of exocyst localization
A0060237biological_processregulation of fungal-type cell wall organization
A0071944cellular_componentcell periphery
A0090334biological_processregulation of cell wall (1->3)-beta-D-glucan biosynthetic process
A1903395biological_processregulation of secondary cell septum biogenesis
A1903501biological_processpositive regulation of mitotic actomyosin contractile ring assembly
B0000148cellular_component1,3-beta-D-glucan synthase complex
B0003843molecular_function1,3-beta-D-glucan synthase activity
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005886cellular_componentplasma membrane
B0005933cellular_componentcellular bud
B0005934cellular_componentcellular bud tip
B0005935cellular_componentcellular bud neck
B0006075biological_process(1->3)-beta-D-glucan biosynthetic process
B0008361biological_processregulation of cell size
B0009272biological_processfungal-type cell wall biogenesis
B0009277cellular_componentfungal-type cell wall
B0016020cellular_componentmembrane
B0016740molecular_functiontransferase activity
B0016757molecular_functionglycosyltransferase activity
B0030476biological_processascospore wall assembly
B0030479cellular_componentactin cortical patch
B0045807biological_processpositive regulation of endocytosis
B0051278biological_processfungal-type cell wall polysaccharide biosynthetic process
B0071555biological_processcell wall organization
B0071944cellular_componentcell periphery
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P61586","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues282
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues82
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues45
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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