8WKL
Rauvolfia serpentina strictosidine synthase (RsSTR) in complex with a non-reactive tryptamine substitute crystallized in P1211 space group
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005773 | cellular_component | vacuole |
| A | 0009820 | biological_process | alkaloid metabolic process |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016844 | molecular_function | strictosidine synthase activity |
| B | 0005773 | cellular_component | vacuole |
| B | 0009820 | biological_process | alkaloid metabolic process |
| B | 0012505 | cellular_component | endomembrane system |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016844 | molecular_function | strictosidine synthase activity |
| C | 0005773 | cellular_component | vacuole |
| C | 0009820 | biological_process | alkaloid metabolic process |
| C | 0012505 | cellular_component | endomembrane system |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016844 | molecular_function | strictosidine synthase activity |
| D | 0005773 | cellular_component | vacuole |
| D | 0009820 | biological_process | alkaloid metabolic process |
| D | 0012505 | cellular_component | endomembrane system |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016844 | molecular_function | strictosidine synthase activity |
| E | 0005773 | cellular_component | vacuole |
| E | 0009820 | biological_process | alkaloid metabolic process |
| E | 0012505 | cellular_component | endomembrane system |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016829 | molecular_function | lyase activity |
| E | 0016844 | molecular_function | strictosidine synthase activity |
| F | 0005773 | cellular_component | vacuole |
| F | 0009820 | biological_process | alkaloid metabolic process |
| F | 0012505 | cellular_component | endomembrane system |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0016829 | molecular_function | lyase activity |
| F | 0016844 | molecular_function | strictosidine synthase activity |
| G | 0005773 | cellular_component | vacuole |
| G | 0009820 | biological_process | alkaloid metabolic process |
| G | 0012505 | cellular_component | endomembrane system |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0016829 | molecular_function | lyase activity |
| G | 0016844 | molecular_function | strictosidine synthase activity |
| H | 0005773 | cellular_component | vacuole |
| H | 0009820 | biological_process | alkaloid metabolic process |
| H | 0012505 | cellular_component | endomembrane system |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0016829 | molecular_function | lyase activity |
| H | 0016844 | molecular_function | strictosidine synthase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00284 |
| Number of Residues | 11 |
| Details | SERPIN Serpins signature. VSADSSFVLvA |
| Chain | Residue | Details |
| A | VAL214-ALA224 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN91 | |
| B | ASN91 | |
| C | ASN91 | |
| D | ASN91 | |
| E | ASN91 | |
| F | ASN91 | |
| G | ASN91 | |
| H | ASN91 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 1 |
| Details | M-CSA 360 |
| Chain | Residue | Details |
| A | GLU309 | activator, hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 1 |
| Details | M-CSA 360 |
| Chain | Residue | Details |
| B | GLU309 | activator, hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity, proton acceptor, proton donor |
| site_id | MCSA3 |
| Number of Residues | 1 |
| Details | M-CSA 360 |
| Chain | Residue | Details |
| C | GLU309 | activator, hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity, proton acceptor, proton donor |
| site_id | MCSA4 |
| Number of Residues | 1 |
| Details | M-CSA 360 |
| Chain | Residue | Details |
| D | GLU309 | activator, hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity, proton acceptor, proton donor |
| site_id | MCSA5 |
| Number of Residues | 1 |
| Details | M-CSA 360 |
| Chain | Residue | Details |
| E | GLU309 | activator, hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity, proton acceptor, proton donor |
| site_id | MCSA6 |
| Number of Residues | 1 |
| Details | M-CSA 360 |
| Chain | Residue | Details |
| F | GLU309 | activator, hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity, proton acceptor, proton donor |
| site_id | MCSA7 |
| Number of Residues | 1 |
| Details | M-CSA 360 |
| Chain | Residue | Details |
| G | GLU309 | activator, hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity, proton acceptor, proton donor |
| site_id | MCSA8 |
| Number of Residues | 1 |
| Details | M-CSA 360 |
| Chain | Residue | Details |
| H | GLU309 | activator, hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity, proton acceptor, proton donor |
