8WJH
Cryo-EM structure of OAT4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005452 | molecular_function | solute:inorganic anion antiporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0008514 | molecular_function | organic anion transmembrane transporter activity |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0009925 | cellular_component | basal plasma membrane |
| A | 0015132 | molecular_function | prostaglandin transmembrane transporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015347 | molecular_function | sodium-independent organic anion transmembrane transporter activity |
| A | 0015698 | biological_process | inorganic anion transport |
| A | 0015711 | biological_process | organic anion transport |
| A | 0015732 | biological_process | prostaglandin transport |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0046415 | biological_process | urate metabolic process |
| A | 0070062 | cellular_component | extracellular exosome |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 109 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-ALA10 | |
| A | SER164-SER174 | |
| A | THR222-MET231 | |
| A | GLU278-SER346 | |
| A | GLY400-ARG402 | |
| A | LYS452-THR463 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY11-ILE31 | |
| A | VAL431-TYR451 | |
| A | ALA464-MET484 | |
| A | LEU491-PHE511 | |
| A | PRO143-LEU163 | |
| A | TRP175-ILE195 | |
| A | PHE201-TRP221 | |
| A | THR232-LEU252 | |
| A | THR257-PRO277 | |
| A | CYS347-LEU367 | |
| A | ALA379-LEU399 | |
| A | THR403-PRO423 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 138 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO32-LYS142 | |
| A | TYR196-ARG200 | |
| A | ARG253-ARG256 | |
| A | GLN368-GLN378 | |
| A | GLN424-ARG430 | |
| A | SER485-PRO490 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN39 | |
| A | ASN56 | |
| A | ASN99 |
