8WGD
mGlu2-4 inactive heterodimer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0001640 | molecular_function | adenylate cyclase inhibiting G protein-coupled glutamate receptor activity |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007196 | biological_process | adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway |
| B | 0007216 | biological_process | G protein-coupled glutamate receptor signaling pathway |
| B | 0007268 | biological_process | chemical synaptic transmission |
| B | 0007269 | biological_process | neurotransmitter secretion |
| B | 0008066 | molecular_function | glutamate receptor activity |
| B | 0016020 | cellular_component | membrane |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0043410 | biological_process | positive regulation of MAPK cascade |
| B | 0043523 | biological_process | regulation of neuron apoptotic process |
| B | 0045202 | cellular_component | synapse |
| B | 0051966 | biological_process | regulation of synaptic transmission, glutamatergic |
| B | 0098793 | cellular_component | presynapse |
| C | 0001641 | molecular_function | group II metabotropic glutamate receptor activity |
| C | 0004930 | molecular_function | G protein-coupled receptor activity |
| C | 0005246 | molecular_function | calcium channel regulator activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0007165 | biological_process | signal transduction |
| C | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| C | 0007194 | biological_process | negative regulation of adenylate cyclase activity |
| C | 0007196 | biological_process | adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway |
| C | 0007215 | biological_process | glutamate receptor signaling pathway |
| C | 0007216 | biological_process | G protein-coupled glutamate receptor signaling pathway |
| C | 0007268 | biological_process | chemical synaptic transmission |
| C | 0008066 | molecular_function | glutamate receptor activity |
| C | 0014047 | biological_process | glutamate secretion |
| C | 0014048 | biological_process | regulation of glutamate secretion |
| C | 0014059 | biological_process | regulation of dopamine secretion |
| C | 0016020 | cellular_component | membrane |
| C | 0030424 | cellular_component | axon |
| C | 0030425 | cellular_component | dendrite |
| C | 0035095 | biological_process | behavioral response to nicotine |
| C | 0042220 | biological_process | response to cocaine |
| C | 0042734 | cellular_component | presynaptic membrane |
| C | 0043005 | cellular_component | neuron projection |
| C | 0045202 | cellular_component | synapse |
| C | 0045211 | cellular_component | postsynaptic membrane |
| C | 0051897 | biological_process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| C | 0051966 | biological_process | regulation of synaptic transmission, glutamatergic |
| C | 0097110 | molecular_function | scaffold protein binding |
| C | 0097449 | cellular_component | astrocyte projection |
| C | 0098978 | cellular_component | glutamatergic synapse |
| C | 0099171 | biological_process | presynaptic modulation of chemical synaptic transmission |
| C | 2001023 | biological_process | regulation of response to drug |
Functional Information from PROSITE/UniProt
| site_id | PS00979 |
| Number of Residues | 19 |
| Details | G_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNILrLFkIPQISyASTA |
| Chain | Residue | Details |
| B | VAL165-ALA183 | |
| C | VAL151-SER169 |
| site_id | PS00980 |
| Number of Residues | 23 |
| Details | G_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCWhCepCtgyqYqv...DryTCktC |
| Chain | Residue | Details |
| B | CYS538-CYS560 | |
| C | CYS518-CYS540 |
| site_id | PS00981 |
| Number of Residues | 11 |
| Details | G_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKpIGFTM |
| Chain | Residue | Details |
| B | PHE781-MET791 | |
| C | PHE756-MET766 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 38 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 94 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Region: {"description":"Important for interaction with HTR2A"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26313429","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26313429","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
