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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8WGC

heterodimer of mGlu2 and mGlu4 bound with mGlu2 agonist LY379268

Functional Information from GO Data
ChainGOidnamespacecontents
A0001640molecular_functionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity
A0004930molecular_functionG protein-coupled receptor activity
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
A0007216biological_processG protein-coupled glutamate receptor signaling pathway
A0007268biological_processchemical synaptic transmission
A0007269biological_processneurotransmitter secretion
A0008066molecular_functionglutamate receptor activity
A0016020cellular_componentmembrane
A0031410cellular_componentcytoplasmic vesicle
A0043410biological_processpositive regulation of MAPK cascade
A0043523biological_processregulation of neuron apoptotic process
A0045202cellular_componentsynapse
A0051966biological_processregulation of synaptic transmission, glutamatergic
A0098793cellular_componentpresynapse
D0001641molecular_functiongroup II metabotropic glutamate receptor activity
D0004930molecular_functionG protein-coupled receptor activity
D0005246molecular_functioncalcium channel regulator activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007194biological_processnegative regulation of adenylate cyclase activity
D0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
D0007215biological_processglutamate receptor signaling pathway
D0007216biological_processG protein-coupled glutamate receptor signaling pathway
D0007268biological_processchemical synaptic transmission
D0008066molecular_functionglutamate receptor activity
D0014047biological_processglutamate secretion
D0014048biological_processregulation of glutamate secretion
D0014059biological_processregulation of dopamine secretion
D0016020cellular_componentmembrane
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0035095biological_processbehavioral response to nicotine
D0042220biological_processresponse to cocaine
D0042734cellular_componentpresynaptic membrane
D0043005cellular_componentneuron projection
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0051966biological_processregulation of synaptic transmission, glutamatergic
D0097110molecular_functionscaffold protein binding
D0097449cellular_componentastrocyte projection
D0098978cellular_componentglutamatergic synapse
D0099171biological_processpresynaptic modulation of chemical synaptic transmission
D2001023biological_processregulation of response to drug
Functional Information from PROSITE/UniProt
site_idPS00979
Number of Residues19
DetailsG_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLrLFqIPQISyASTS
ChainResidueDetails
DVAL151-SER169
AVAL165-ALA183
site_idPS00980
Number of Residues23
DetailsG_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCWlCipCqpyeYrl...DefTCadC
ChainResidueDetails
DCYS518-CYS540
ACYS538-CYS560
site_idPS00981
Number of Residues11
DetailsG_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKfIGFTM
ChainResidueDetails
DPHE756-MET766
APHE781-MET791
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues73
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues94
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues36
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues50
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues8
DetailsRegion: {"description":"Important for interaction with HTR2A"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26313429","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26313429","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues6
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2025-12-24

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