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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8WG9

mGlu2-mGlu4 heterodimer bound mGlu4 agonist E7P

Functional Information from GO Data
ChainGOidnamespacecontents
B0001640molecular_functionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity
B0004930molecular_functionG protein-coupled receptor activity
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
B0007216biological_processG protein-coupled glutamate receptor signaling pathway
B0007268biological_processchemical synaptic transmission
B0007269biological_processneurotransmitter secretion
B0008066molecular_functionglutamate receptor activity
B0016020cellular_componentmembrane
B0031410cellular_componentcytoplasmic vesicle
B0043410biological_processpositive regulation of MAPK cascade
B0043523biological_processregulation of neuron apoptotic process
B0045202cellular_componentsynapse
B0051966biological_processregulation of synaptic transmission, glutamatergic
B0098793cellular_componentpresynapse
C0001641molecular_functiongroup II metabotropic glutamate receptor activity
C0004930molecular_functionG protein-coupled receptor activity
C0005246molecular_functioncalcium channel regulator activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
C0007194biological_processnegative regulation of adenylate cyclase activity
C0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
C0007215biological_processglutamate receptor signaling pathway
C0007216biological_processG protein-coupled glutamate receptor signaling pathway
C0007268biological_processchemical synaptic transmission
C0008066molecular_functionglutamate receptor activity
C0010467biological_processgene expression
C0014047biological_processglutamate secretion
C0014048biological_processregulation of glutamate secretion
C0014059biological_processregulation of dopamine secretion
C0016020cellular_componentmembrane
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0033554biological_processcellular response to stress
C0035095biological_processbehavioral response to nicotine
C0042220biological_processresponse to cocaine
C0042734cellular_componentpresynaptic membrane
C0042995cellular_componentcell projection
C0043005cellular_componentneuron projection
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0051966biological_processregulation of synaptic transmission, glutamatergic
C0060292biological_processlong-term synaptic depression
C0090461biological_processintracellular glutamate homeostasis
C0097110molecular_functionscaffold protein binding
C0097449cellular_componentastrocyte projection
C0098978cellular_componentglutamatergic synapse
C0099171biological_processpresynaptic modulation of chemical synaptic transmission
C2001023biological_processregulation of response to drug
Functional Information from PROSITE/UniProt
site_idPS00979
Number of Residues19
DetailsG_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLrLFqIPQISyASTS
ChainResidueDetails
CVAL151-SER169
BVAL165-ALA183
site_idPS00980
Number of Residues23
DetailsG_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCWlCipCqpyeYrl...DefTCadC
ChainResidueDetails
CCYS518-CYS540
BCYS538-CYS560
site_idPS00981
Number of Residues11
DetailsG_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKfIGFTM
ChainResidueDetails
CPHE756-MET766
BPHE781-MET791
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues73
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues94
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues36
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues50
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues6
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues7
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues8
DetailsRegion: {"description":"Important for interaction with HTR2A"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26313429","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26313429","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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