8WG4
mouse TMEM63b in DDM-CHS micelle with YN9303-24 Fab
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005227 | molecular_function | calcium-activated cation channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005768 | cellular_component | endosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006887 | biological_process | exocytosis |
| A | 0007605 | biological_process | sensory perception of sound |
| A | 0008218 | biological_process | bioluminescence |
| A | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| A | 0015629 | cellular_component | actin cytoskeleton |
| A | 0015914 | biological_process | phospholipid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0017121 | biological_process | plasma membrane phospholipid scrambling |
| A | 0017128 | molecular_function | phospholipid scramblase activity |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0036335 | biological_process | intestinal stem cell homeostasis |
| A | 0042756 | biological_process | drinking behavior |
| A | 0097233 | cellular_component | alveolar lamellar body membrane |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 0120009 | biological_process | intermembrane lipid transfer |
| A | 0120019 | molecular_function | phosphatidylcholine transfer activity |
| A | 0140135 | molecular_function | mechanosensitive monoatomic cation channel activity |
| A | 0140338 | molecular_function | sphingomyelin transfer activity |
| A | 0160069 | biological_process | surfactant secretion |
| A | 1990760 | molecular_function | osmolarity-sensing monoatomic cation channel activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=TM0","evidences":[{"source":"PubMed","id":"39424995","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8WG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Helical; Name=TM1","evidences":[{"source":"PubMed","id":"39424995","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8WG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 65 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39424995","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8WG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"39424995","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8WG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 227 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39424995","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8WG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 29 |
| Details | Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"39424995","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8WG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 29 |
| Details | Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"39424995","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8WG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"39424995","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8WG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"39424995","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8WG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"39424995","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8WG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"39424995","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8WG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"39424995","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8WG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"39424995","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8WG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 195 |
| Details | Region: {"description":"Intracellular linker IL2; confers mechanosensitivity","evidences":[{"source":"UniProtKB","id":"Q5T3F8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 32 |
| Details | Region: {"description":"Gating helix","evidences":[{"source":"UniProtKB","id":"Q5T3F8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 6 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"39424995","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
